ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Eukaryotic Gene Expression
インパクトファクター: 1.841 5年インパクトファクター: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.50
pages 317-335

Transcriptional Control Mechanisms in the Regulation of Cholesterol Balance

Timothy F. Osborne
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92717-3900

要約

The mechanisms that govern regulation of cholesterol metabolism in higher eukaryotic cells provide an example of how metabolic regulation has evolved to establish growth and nutritional control in a multicellular environment. Two sources of cholesterol must be balanced to ensure optimum growth and viability. Much of the control is established by regulating the levels of key proteins involved in cholesterol uptake and biosynthesis and this occurs by alterations in promoter activity. The studies discussed here track the progression in understanding the mechanism for transcriptional regulation by cholesterol from the isolation of the key genes involved, to the careful dissection of the cis-acting sequences that control expression, and on to what is currently known about the trans-acting proteins that mediate the regulatory response.


Articles with similar content:

Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Aswathy K. Nair, Eric D. Jensen, Jennifer J. Westendorf
Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Sayyed Kaleem Zaidi, Janet L. Stein, Jane B. Lian, Martin Montecino, Andre J. van Wijnen, Amjad Javed, Gary S. Stein, Christopher Lengner
Structure-Function Studies of ETS Transcription Factors
Critical Reviews™ in Oncogenesis, Vol.11, 2000, issue 3&4
Murielle Mimeault
Extracellular Vesicles as Potential Mediators of Epigenetic Reprogramming
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Anna Lewandowska Ronnegren
Mechanisms Controlling Embryonic Stem Cell Self-Renewal and Differentiation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 3
Huai Li, Ming Zhan, Henry Yang, Yu Sun, Mahendra S. Rao