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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

CREB-Mediated Transcriptional Control

巻 9, 発行 1, 1999, pp. 19-32
DOI: 10.1615/CritRevEukaryotGeneExpr.v9.i1.20
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要約

cAMP-response-element-binding protein, CREB, is a 43-kDa leucine zipper transcription factor identified and cloned via the study of cAMP-regulated genes. In the last decade, numerous studies have contributed much to our understanding of CREB structure, function, and CREB-mediated transcription. CREB binds to the cAMP-response-element (CRE) as a homodimer formed via the leucine zipper motif present at its C-terminus; its transcriptional activity is regulated by phosphorylation at Ser133, located within the N-terminal transactivation domain. Active, Ser133-phosphorylated CREB effects transcription of CRE-dependent genes via interaction with the 265-kDa co-activator protein CREB-binding-protein, CBP, which bridges the CRE/CREB complex to components of the basal transcriptional apparatus. This mechanism of CREB activation is effected by diverse signals, including those regulating the intracellular levels of cAMP and Ca+2, growth factors, and cellular stress. Accordingly, CREB-mediated transcription regulates diverse cellular responses, including intermediary metabolism, neuronal signaling, cell proliferation, and apoptosis. In addition to the regulation of CREB by phosphorylation, the viral oncoproteins HBV pX and HTLVI Tax regulate CREB transcriptional efficacy by an alternative mechanism, by increasing its DNA-binding affinity for viral and/or cellular CRE sites.
In this review I describe key experiments that have defined the mechanism of CREB activation, with primary emphasis on emerging evidence linking CREB to cellular growth and development.

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