年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Heparan Sulfate-based Treatments for Regenerative Medicine
要約
This review summarizes the emerging strategies that exploit the glycosaminoglycan sugar, heparan sulfate (HS), either as a substitute for, or as a supplement to growth factor (GF) therapy for regenerative medicine. Excluding autograft, the administration of GFs is currently the most effective treatment for critical bone repair and restoration. However, major hurdles in the clinical development of GF therapies include the high cost, the unwanted side effects, and the toxicity associated with the physiological overdosing required to achieve a successful outcome. These drawbacks may be overcome with the application of particular HS fractions that have been optimized to bind, recruit and enhance the biological activity of endogenous GF at the site of injury. Three HS-based treatments are discussed here: first, the single, localized, and sustained delivery of HS as a stand-alone therapeutic agent; then, the inclusion of an HS component within a delivery device so as to stabilize and potentiate the bioactivity of the incorporated GF; and finally, the growing use of HS mimetics, particularly for bone repair.
-
Büttner Marianne, Möller Stephanie, Keller Mario, Huster Daniel, Schiller Jürgen, Schnabelrauch Matthias, Dieter Peter, Hempel Ute, Over-sulfated chondroitin sulfate Derivatives induce osteogenic differentiation of hMSC independent of BMP-2 and TGF-β1 signalling, Journal of Cellular Physiology, 228, 2, 2013. Crossref
-
Lorden Elizabeth R., Levinson Howard M., Leong Kam W., Integration of drug, protein, and gene delivery systems with regenerative medicine, Drug Delivery and Translational Research, 5, 2, 2015. Crossref
-
Xu Ruoyan, Rudd Timothy R., Hughes Ashley J, Siligardi Giuliano, Fernig David G., Yates Edwin A., Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network, FEBS Journal, 280, 10, 2013. Crossref
-
Murali S., Rai B., Dombrowski C., Lee J.L.J., Lim Z.X.H., Bramono D.S., Ling L., Bell T., Hinkley S., Nathan S.S., Hui J.H., Wong H.K., Nurcombe V., Cool S.M., Affinity-selected heparan sulfate for bone repair, Biomaterials, 34, 22, 2013. Crossref
-
Princz M.A., Sheardown H., Heparin-modified dendrimer crosslinked collagen matrices for the delivery of heparin-binding epidermal growth factor, Journal of Biomedical Materials Research Part A, 100A, 8, 2012. Crossref
-
He Hongyan, Liu Changsheng, Stem Cell Differentiation Mediated by Biomaterials/Surfaces, in Polymeric Biomaterials for Tissue Regeneration, 2016. Crossref
-
Melrose James, Glycosaminoglycans in Wound Healing, Bone and Tissue Regeneration Insights, 7, 2016. Crossref
-
Jiang Xianfang, Liu Junting, Liu Qin, Lu Zhenhui, Zheng Li, Zhao Jinmin, Zhang Xingdong, Therapy for cartilage defects: functional ectopic cartilage constructed by cartilage-simulating collagen, chondroitin sulfate and hyaluronic acid (CCH) hybrid hydrogel with allogeneic chondrocytes, Biomaterials Science, 6, 6, 2018. Crossref
-
Liu Yi, Xu Zhujie, Wang Qiqi, Jiang Yuyu, Wang Rui, Chen Shayang, Zhu Jingyu, Zhang Yan, Chen Jinghua, Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor β in MC3T3-E1 cells, International Journal of Biological Macromolecules, 161, 2020. Crossref
-
Zhao Yunlong, Abzalimov Rinat R., Kaltashov Igor A., Interactions of Intact Unfractionated Heparin with Its Client Proteins Can Be Probed Directly Using Native Electrospray Ionization Mass Spectrometry, Analytical Chemistry, 88, 3, 2016. Crossref
-
Filipczak Nina, Yalamarty Satya Siva Kishan, Li Xiang, Khan Muhammad Muzamil, Parveen Farzana, Torchilin Vladimir, Lipid-Based Drug Delivery Systems in Regenerative Medicine, Materials, 14, 18, 2021. Crossref
-
Rinker Torri E., Philbrick Brandon D., Hettiaratchi Marian H., Smalley David M., McDevitt Todd C., Temenoff Johnna S., Microparticle-mediated sequestration of cell-secreted proteins to modulate chondrocytic differentiation, Acta Biomaterialia, 68, 2018. Crossref
-
Hintze Vera, Samsonov Sergey A., Anselmi Massimiliano, Moeller Stephanie, Becher Jana, Schnabelrauch Matthias, Scharnweber Dieter, Pisabarro M. Teresa, Sulfated Glycosaminoglycans Exploit the Conformational Plasticity of Bone Morphogenetic Protein-2 (BMP-2) and Alter the Interaction Profile with Its Receptor, Biomacromolecules, 15, 8, 2014. Crossref
-
Rother Sandra, Salbach-Hirsch Juliane, Moeller Stephanie, Seemann Thomas, Schnabelrauch Matthias, Hofbauer Lorenz C., Hintze Vera, Scharnweber Dieter, Bioinspired Collagen/Glycosaminoglycan-Based Cellular Microenvironments for Tuning Osteoclastogenesis, ACS Applied Materials & Interfaces, 7, 42, 2015. Crossref
-
Li Qiu, Niu Yiming, Diao Huajia, Wang Lintao, Chen Xiuping, Wang Yitao, Dong Lei, Wang Chunming, In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing, Biomaterials, 148, 2017. Crossref
-
Zhao Shancheng, Wang Zhen, Chen Jingxiao, Chen Jinghua, Preparation of heparan sulfate-like polysaccharide and application in stem cell chondrogenic differentiation, Carbohydrate Research, 401, 2015. Crossref
-
Xu Zhujie, Chen Shayang, Feng Dehong, Liu Yi, Wang Qiqi, Gao Tianshu, Liu Zhenwei, Zhang Yan, Chen Jinghua, Qiu Lipeng, Biological role of heparan sulfate in osteogenesis: A review, Carbohydrate Polymers, 272, 2021. Crossref
-
Rai B., Chatterjea A., Lim Z.X.H., Tan T.C., Sawyer A.A., Hosaka Y.Z., Murali S., Lee J.J.L., Fenwick S.A., Hui J.H., Nurcombe V., Cool S.M., Repair of segmental ulna defects using a β-TCP implant in combination with a heparan sulfate glycosaminoglycan variant, Acta Biomaterialia, 28, 2015. Crossref
-
Rnjak‐Kovacina Jelena, Tang Fengying, Whitelock John M., Lord Megan S., Glycosaminoglycan and Proteoglycan‐Based Biomaterials: Current Trends and Future Perspectives, Advanced Healthcare Materials, 7, 6, 2018. Crossref
-
Smith Margaret M., Hayes Anthony J., Melrose James, Pentosan Polysulfate, a Semisynthetic Heparinoid Disease-Modifying Osteoarthritic Drug with Roles in Intervertebral Disc Repair Biology Emulating the Stem Cell Instructive and Tissue Reparative Properties of Heparan Sulfate, Stem Cells and Development, 31, 15-16, 2022. Crossref