年間 6 号発行
ISSN 印刷: 1045-4403
ISSN オンライン: 2162-6502
Indexed in
Interleukin-1 Beta +3594 C/T Gene Polymorphism and Susceptibility to Sepsis: A Meta-Analysis
要約
Emerging evidence has indicated that the interleukin-1B (IL-1B) +3954 C > T polymorphism may affect individual susceptibility to sepsis. However, the results of published studies are inconclusive. The aim of this meta-analysis was to elucidate the association of this polymorphism with sepsis risk. Eligible studies were identified by a search of electronic databases. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the associations between the IL-1B +3954 C > T polymorphism and sepsis risk. Six case–control studies were included in this meta-analysis. The pooled analysis indicated that the IL-1B +3954 C > T polymorphism significantly decreased the risk of sepsis under the homozygote model (TT vs. CC: OR = 0.57, 95% CI:0.37–0.88). In stratified analysis, we found that the protective effect of the IL-1B +3954 C > T polymorphism on sepsis risk remained significant in the subgroup of Caucasians and for high-quality studies. In conclusion, the IL-1B +3954 C > T polymorphism is associated with decreased sepsis risk in Caucasians. Further well-designed studies with large sample sizes are required to confirm this conclusion.
-
Fu Peng, Xie Shouxiang, Zhang Xiangcheng, Investigation of the IL-1β +3954 C>T polymorphism and the risk of sepsis, Medicine, 99, 31, 2020. Crossref
-
Sljivancanin Jakovljevic Tamara, Martic Jelena, Jacimovic Jelena, Nikolic Nadja, Milasin Jelena, Mitrović Tanja Lazić, Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis, World Journal of Pediatrics, 2022. Crossref