年間 12 号発行
ISSN 印刷: 1044-5110
ISSN オンライン: 1936-2684
Indexed in
THEORETICAL INVESTIGATION OF THE SPRAY FROM A PRESSURIZED METERED-DOSE INHALER
要約
This research was concerned with the theoretical investigation of the spray issued from a pressurized metered-dose inhaler (pMDI). The theoretical investigation of the pMDI spray consisted of constructing a model of the fluid flow through the pMDI that was based on a quasi-steady-state separated flow analysis during a single actuation and included a qualitative and quantitative description of the primary atomization process, the resultant spray model being calculated from the solution of the multiphase transport equations using the discrete droplet model (DDM). The predicted results were validated against detailed temporal and spatial experimental data obtained using phase Doppler particle analysis (PDPA).
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Zhu Bing, Traini Daniela, Young Paul, Aerosol particle generation from solution-based pressurized metered dose inhalers: a technical overview of parameters that influence respiratory deposition, Pharmaceutical Development and Technology, 20, 8, 2015. Crossref
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Kleinstreuer Clement, Shi Huawei, Zhang Zhe, Computational Analyses of a Pressurized Metered Dose Inhaler and a New Drug–Aerosol Targeting Methodology, Journal of Aerosol Medicine, 20, 3, 2007. Crossref
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Bell John, Newman Steve, The rejuvenated pressurised metered dose inhaler, Expert Opinion on Drug Delivery, 4, 3, 2007. Crossref
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Smyth Hugh D. C., Multimodal particle size distributions emitted from HFA-134a solution pressurized metered-dose inhalers, AAPS PharmSciTech, 4, 3, 2003. Crossref
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Versteeg H K, Hargrave G K, Kirby M, Internal Flow and Near-Orifice Spray Visualisations of a Model Pharmaceutical Pressurised Metered Dose Inhaler, Journal of Physics: Conference Series, 45, 2006. Crossref
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Crosland Brian Michael, Johnson Matthew Ronald, Matida Edgar Akio, Characterization of the Spray Velocities from a Pressurized Metered-Dose Inhaler, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 22, 2, 2009. Crossref
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DUNBAR C.A., WATKINS A.P., MILLER J.F., An Experimental Investigation of the Spray Issued from a pMDI Using Laser Diagnostic Techniques, Journal of Aerosol Medicine, 10, 4, 1997. Crossref
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Ivey James W, Vehring Reinhard, Finlay Warren H, Understanding pressurized metered dose inhaler performance, Expert Opinion on Drug Delivery, 12, 6, 2015. Crossref
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Smyth Hugh DC, Propellant-driven metered-dose inhalers for pulmonary drug delivery, Expert Opinion on Drug Delivery, 2, 1, 2005. Crossref
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Smyth Hugh D. C., Beck Vance P., Williams Dennis, Hickey Anthony J., The influence of formulation and spacer device on the in vitro performance of solution chlorofluorocarbon-free propellant-driven metered dose inhalers, AAPS PharmSciTech, 5, 1, 2004. Crossref
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Smyth Hugh, Brace Geoff, Barbour Tony, Gallion Jim, Grove Joe, Hickey Anthony J., Spray Pattern Analysis for Metered Dose Inhalers: Effect of Actuator Design, Pharmaceutical Research, 23, 7, 2006. Crossref
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Hickey Anthony J., Holt Jay, Surface interactions in propellant driven metered dose inhaler product design, in Colloid and Interface Science in Pharmaceutical Research and Development, 2014. Crossref
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Ruzycki Conor A, Javaheri Emadeddin, Finlay Warren H, The use of computational fluid dynamics in inhaler design, Expert Opinion on Drug Delivery, 10, 3, 2013. Crossref
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Martin Andrew R., Finlay Warren H., Aerosol Drug Delivery to the Lungs, in Pharmaceutical Sciences Encyclopedia, 2011. Crossref
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Zhu Bing, Traini Daniela, Chan Hak-Kim, Young Paul M., The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers, Drug Development and Industrial Pharmacy, 39, 11, 2013. Crossref
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Stein Stephen W., Myrdal Paul B., The Relative Influence of Atomization and Evaporation on Metered Dose Inhaler Drug Delivery Efficiency, Aerosol Science and Technology, 40, 5, 2006. Crossref
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Smyth Hugh D.C, The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers, Advanced Drug Delivery Reviews, 55, 7, 2003. Crossref
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Smyth Hugh D. C., Beck Vance P., Williams Dennis, Hickey Anthony J., The influence of formulation and spacer device on the in vitro performance of solution chlorofluorocarbon-free propellant-driven metered dose inhalers, AAPS PharmSciTech, 5, 1, 2004. Crossref
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Jones Latarsha, Garcia-Contreras Lucila, Smyth Hugh, Garmise Robert, Hickey Anthony, Cooney Daniel, Medical and pharmaceutical aerosols, in Aerosols Handbook, 2004. Crossref
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Stein Stephen W., Sheth Poonam, Hodson P. David, Myrdal Paul B., Advances in Metered Dose Inhaler Technology: Hardware Development, AAPS PharmSciTech, 15, 2, 2014. Crossref
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Marek Stephen, Smyth Hugh, Garcia-Contreras Lucila, Cooney Daniel, Garmise Robert, Jones Latarsha, Hickey Anthony, Medical and Pharmaceutical Aerosols, in Aerosols Handbook, 2012. Crossref
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Murnane Darragh, Hutter Victoria, Harang Marie, Pharmaceutical Aerosols and Pulmonary Drug Delivery, in Aerosol Science, 2014. Crossref
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Ivey James W., Lewis David, Church Tanya, Finlay Warren H., Vehring Reinhard, A correlation equation for the mass median aerodynamic diameter of the aerosol emitted by solution metered dose inhalers, International Journal of Pharmaceutics, 465, 1-2, 2014. Crossref
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Lee Eunju, Park Jinwoo, Huh Kang Y., Choi Jaejoon, Bae Choongsik, Simulation of Fuel/Air Mixture Formation for Heavy Duty Liquid Phase LPG Injection (LPLI) Engines, SAE Technical Paper Series, 1, 2003. Crossref
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Finlay Warren H., Metered dose propellant inhalers, in The Mechanics of Inhaled Pharmaceutical Aerosols, 2001. Crossref
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Finlay Warren H., Particle size changes due to evaporation or condensation, in The Mechanics of Inhaled Pharmaceutical Aerosols, 2001. Crossref
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Watkins A.P., Modelling the mean temperatures used for calculating heat and mass transfer in sprays, International Journal of Heat and Fluid Flow, 28, 3, 2007. Crossref
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Aamir M.A., Watkins A.P., Numerical analysis of depressurisation of highly pressurised liquid propane, International Journal of Heat and Fluid Flow, 21, 4, 2000. Crossref
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Gavtash B., Versteeg H. K., Hargrave G., Myatt B., Lewis D., Church T., Brambilla G., Transient flashing propellant flow models to predict internal flow characteristics, spray velocity, and aerosol droplet size of a pMDI, Aerosol Science and Technology, 51, 5, 2017. Crossref
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Yousefi Morteza, Inthavong Kiao, Tu Jiyuan, Effect of Pressurized Metered Dose Inhaler Spray Characteristics and Particle Size Distribution on Drug Delivery Efficiency, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30, 5, 2017. Crossref
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Gavtash B., Versteeg H. K., Hargrave G., Myatt B., Lewis D., Church T., Brambilla G., Transient aerodynamic atomization model to predict aerosol droplet size of pressurized metered dose inhalers (pMDI), Aerosol Science and Technology, 51, 8, 2017. Crossref
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Martin Andrew R., Kwok Daniel Y., Finlay Warren H., Investigating the Evaporation of Metered-Dose Inhaler Formulations in Humid Air: Single Droplet Experiments, Journal of Aerosol Medicine, 18, 2, 2005. Crossref
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Longest P. Worth, Hindle Michael, Quantitative Analysis and Design of a Spray Aerosol Inhaler. Part 1: Effects of Dilution Air Inlets and Flow Paths, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 22, 3, 2009. Crossref
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Byron Peter R., Hindle Michael, Lange Carlos F., Longest P. Worth, McRobbie Donald, Oldham Michael J., Olsson Bo, Thiel Charles G., Wachtel Herbert, Finlay Warren H., In Vivo–In VitroCorrelations: Predicting Pulmonary Drug Deposition from Pharmaceutical Aerosols, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23, S2, 2010. Crossref
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DUNBAR C.A., ATOMIZAT10N MECHANISMS OF THE PRESSURIZED METERED DOSE INHALER, Particulate Science and Technology, 15, 3-4, 1997. Crossref
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Mason-Smith Nicholas, Duke Daniel J., Kastengren Alan L., Traini Daniela, Young Paul M., Chen Yang, Lewis David A., Edgington-Mitchell Daniel, Honnery Damon, Revealing pMDI Spray Initial Conditions: Flashing, Atomisation and the Effect of Ethanol, Pharmaceutical Research, 34, 4, 2017. Crossref
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McKiernan Alan Patrick, Inhaler Spray Investigation Using High-Speed Phase-Contrast X-Ray and Schlieren Imaging, Pharmaceutical Research, 36, 8, 2019. Crossref
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Finlay Warren H., Metered-dose propellant inhalers, in The Mechanics of Inhaled Pharmaceutical Aerosols, 2019. Crossref
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Finlay W. H., Pharmaceutical Aerosol Sprays for Drug Delivery to the Lungs, in Handbook of Atomization and Sprays, 2011. Crossref
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Finlay Warren H., Particle size changes due to evaporation or condensation, in The Mechanics of Inhaled Pharmaceutical Aerosols, 2019. Crossref
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Xu Zhen, Hickey Anthony J., The Physics of Aerosol Droplet and Particle Generation from Inhalers, in Controlled Pulmonary Drug Delivery, 2011. Crossref
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Calay R.K., Holdo A.E., Modelling the dispersion of flashing jets using CFD, Journal of Hazardous Materials, 154, 1-3, 2008. Crossref