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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 印刷: 0278-940X
ISSN オンライン: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2014010689
pages 425-434

Numerical Simulations of Deformation and Aggregation of Red Blood Cells in Shear Flow

Hong-Tong Low
Division of Bioengineering, Department of Mechanical Engineering, National University of Singapore, Singapore 117576
M. Ju
Department of Biomedical Engineering, National University of Singapore, Singapore
Y. Sui
School of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom
T. Nazir
Department of Mechanical Engineering, National University of Singapore, Singapore
B. Namgung
Department of Biomedical Engineering, National University of Singapore, Singapore
Sangho Kim
Department of Bioengineering, National University of Singapore, Singapore 117575

要約

This article reviews numerical simulations of red blood cells (RBCs) mainly using the lattice Boltzmann method (LBM), focusing on the 2-dimensional deformation and aggregation of the cells in simple shear flow. We outline the incorporation of the immersed boundary method into the LBM, in which the membrane forces are obtained from the membrane model. The RBCs are simulated as a single biconcave capsule and as a doublet of biconcave capsules. The transition from swinging to tumbling motions of the RBCs, as induced by reducing the shear rate or increasing the membrane bending stiffness, is discussed. Also discussed is the aggregation tendency of the doublet of RBCs, for which homogenous deformability maintained RBC aggregation, whereas an increased deformability difference resulted in RBC dissociation.


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