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Critical Reviews™ in Oncogenesis

年間 4 号発行

ISSN 印刷: 0893-9675

ISSN オンライン: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Driving Cytotoxic Natural Killer Cells into Melanoma: If CCL5 Plays the Music, Autophagy Calls the Shots

巻 23, 発行 5-6, 2018, pp. 321-332
DOI: 10.1615/CritRevOncog.2018027526
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要約

Autophagy is a quality control process executed at the basal level in almost all cell types. However, in cancer cells, autophagy is activated by several stimuli, including hypoxia. Depending on tumor type, stage, and genetic context, autophagy is a double-edged sword. Autophagy promotes regression in newly established tumors; however, it supports tumor progression in well-established tumors by maintaining cancer cell survival under stress conditions. These data, in addition to the emerging role of autophagy in impairing antitumor immunity, have attracted significant interest in developing autophagy inhibitors as a new approach to cancer treatment. The enthusiasm for developing selective drugs inhibiting autophagy has been seriously challenged by the discovery that most autophagy-related proteins display nonautophagic functions. Autophagy inhibitors chloroquine and hydroxychloroquine are currently being investigated in several clinical trials in combination with standard anticancer therapies. Here, we provide a brief overview on the nonautophagic function of autophagy-related proteins and summarize the major mechanisms whereby autophagy modulation could positively or negatively impact cancer therapies. We also focus on the emerging role of targeting autophagy in the improvement of NK-mediated antitumor immunity through the regulation of CCL5 and its receptors' expression in melanoma, and we provide some clues revealing how autophagy modulators could be exploited to improve cancer immunotherapies.

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  1. Xiao Malina, Benoit Alice, Hasmim Meriem, Duhem Caroline, Vogin Guillaume, Berchem Guy, Noman Muhammad Zaeem, Janji Bassam, Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies, Frontiers in Oncology, 11, 2021. Crossref

  2. Noman Muhammad Zaeem, Parpal Santiago, Van Moer Kris, Xiao Malina, Yu Yasmin, Arakelian Tsolere, Viklund Jenny, De Milito Angelo, Hasmim Meriem, Andersson Martin, Amaravadi Ravi K., Martinsson Jessica, Berchem Guy, Janji Bassam, Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy, Science Advances, 6, 18, 2020. Crossref

  3. Wu Lin, Shen Bowen, Li Junpeng, Zhang Huirong, Zhang Ke, Yang Yao, Zu Zhenyu, Shen Dongxiang, Luo Min, STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer, Diagnostic Pathology, 17, 1, 2022. Crossref

  4. Degan Simone, May Brian L., Jin Yingai J., Hammoda Manel Ben, Sun Huiying, Zhang Guoqiang, Wang Yan, Erdmann Detlev, Warren Warren, Zhang Jennifer Y., Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration, Frontiers in Oncology, 12, 2022. Crossref

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