年間 6 号発行
ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X
Indexed in
Microsponges: A Pioneering Tool for Biomedical Applications
要約
Microparticulate drug delivery systems have been explored across the globe due to their various advantages. In 1987, Won developed microsponge systems (Micsys), also known as solid-phase porous microspheres, having numerous interconnected voids, which serve as non-collapsible residence for bioactive compounds. A Micsys particle ranges from 5 to 300 μm in size and shows a wide range of entrapment efficiency with desired release rates. This topical drug delivery system bestows a controlled release of bioactive compounds into the skin with reduced systemic side effects. Currently, the application fields of this promising system include oral, ocular, pulmonary, and parenteral delivery of bioactive compounds. In the present review, we summarize the updated biomedical application potential of Micsys as an effective drug-delivery vector, including an in-depth explanation of the drug-release kinetic models and drug-release mechanisms. We also discuss different techniques used to prepare a Micsys, along with their advantages and disadvantages. Moreover, in this review, we report a plethora of Micsys details, such as drug candidates and polymers, exploited in this field, along with marketed formulations, characterization methods, clinical perspectives, and patents received. This assembly of detailed literature summaries will contribute to future advances in the development of porous carriers.
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Jain Ankit, Jain Sanjay K., In vitro release kinetics model fitting of liposomes: An insight, Chemistry and Physics of Lipids, 201, 2016. Crossref
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Verma Amit, Jain Ankit, Tiwari Ankita, Jain Sanjay K., Emulgels: Application Potential in Drug Delivery, in Functional Biopolymers, 2018. Crossref
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Jain Sanjay Kumar, Tiwari Ankita, Jain Ankit, Verma Amit, Saraf Shivani, Panda Pritish Kumar, Gour Gaytri, Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery, in Multifunctional Nanocarriers for Contemporary Healthcare Applications, 2018. Crossref
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Kumari Amrita, Jain Ankit, Hurkat Pooja, Tiwari Ankita, Jain Sanjay K., Eudragit S100 coated microsponges for Colon targeting of prednisolone, Drug Development and Industrial Pharmacy, 44, 6, 2018. Crossref
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Ivanova Nadezhda Antonova, Trapani Adriana, Franco Cinzia Di, Mandracchia Delia, Trapani Giuseppe, Franchini Carlo, Corbo Filomena, Tripodo Giuseppe, Kolev Iliyan Nikolov, Stoyanov Georgi Stoyanov, Bratoeva Kameliya Zhechkova, In vitro and ex vivo studies on diltiazem hydrochloride-loaded microsponges in rectal gels for chronic anal fissures treatment, International Journal of Pharmaceutics, 557, 2019. Crossref
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Junqueira Mariana Volpato, Bruschi Marcos Luciano, A Review About the Drug Delivery from Microsponges, AAPS PharmSciTech, 19, 4, 2018. Crossref
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Wadhwa Geetika, Kumar Sunil, Mittal Vineet, Rao Rekha, Encapsulation of babchi essential oil into microsponges: Physicochemical properties, cytotoxic evaluation and anti-microbial activity, Journal of Food and Drug Analysis, 27, 1, 2019. Crossref
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Prajapati Shiv Kumar, Jain Ankit, Jain Aakanchha, Jain Sourabh, Biodegradable polymers and constructs: A novel approach in drug delivery, European Polymer Journal, 120, 2019. Crossref
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Jain Ankit, Prajapati Shiv Kumar, Kumari Amrita, Mody Nishi, Bajpai Meenakshi, Engineered nanosponges as versatile biodegradable carriers: An insight, Journal of Drug Delivery Science and Technology, 57, 2020. Crossref
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Sharma Ruchi, Kumar Nitish, Singh Sompal P., Kumar Sunil, Rao Rekha, Ecofriendly Ethyl Cellulose Microsponges of Citronella Oil: Preparation, Characterization and Evaluation of Cytotoxicity and Larvicidal assay, Current Pharmaceutical Biotechnology, 21, 4, 2020. Crossref
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Srivastava Aakanksha, Verma Amit, Saraf Shivani, Jain Ankit, Tiwari Ankita, Panda Pritish K., Jain Sanjay Kumar, Mucoadhesive gastroretentive microparticulate system for programmed delivery of famotidine and clarithromycin, Journal of Microencapsulation, 38, 3, 2021. Crossref
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Jain Ankit, Tripathi Madhavi, Prajapati Shiv K., Raichur Ashok M., Biopolymer Matrix Composite for Drug Delivery Applications in Cancer, in Encyclopedia of Materials: Composites, 2021. Crossref
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Zhang Huaqing, Jin Yi, Chi Cheng, Han Guochen, Jiang Wenxin, Wang Zhen, Cheng Hao, Zhang Chenshuang, Wang Gang, Sun Chenhua, Chen Yun, Xi Yilong, Liu Mengting, Gao Xie, Lin Xiujun, Lv Lingyu, Zhou Jianping, Ding Yang, Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications, Biomaterials, 273, 2021. Crossref
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Junqueira Mariana Volpato, Calçado Sabrina Célia, de Castro-Hoshino Lidiane Vizioli, Baesso Mauro Luciano, Szarpak-Jankowska Anna, Auzély-Velty Rachel, Bruschi Marcos Luciano, Influence of the ethanol/dichloromethane ratio on the preparation of microsponges composed of ethylcellulose and Eudragit or HPMCphthalate for hydrophilic drug delivery, Journal of Molecular Liquids, 303, 2020. Crossref
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Arribada Raquel Gregorio, Behar-Cohen Francine, de Barros Andre Luis Branco, Silva-Cunha Armando, The Use of Polymer Blends in the Treatment of Ocular Diseases, Pharmaceutics, 14, 7, 2022. Crossref
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Mullick Prashansha, R. Hegde Aswathi, Gopalan Divya, Pandey Abhijeet, Nandakumar Krishnadas, Jain Sanyog, Kuppusamy Gowthamarajan, Mutalik Srinivas, Evolving Era of “Sponges”: Nanosponges as a Versatile Nanocarrier for the Effective Skin Delivery of Drugs, Current Pharmaceutical Design, 28, 23, 2022. Crossref
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Nishal Suchitra, Phaugat Parmita , Tushir Renu , Dhall Manish , A CONCISE LITERATURE REVIEW ON STUDY OF MICROSPONGES FROM ANCIENT TO RECENT, Indian Drugs, 59, 09, 2022. Crossref