ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Therapeutic Drug Carrier Systems
インパクトファクター: 2.9 5年インパクトファクター: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X

巻:
巻 36, 2019 巻 35, 2018 巻 34, 2017 巻 33, 2016 巻 32, 2015 巻 31, 2014 巻 30, 2013 巻 29, 2012 巻 28, 2011 巻 27, 2010 巻 26, 2009 巻 25, 2008 巻 24, 2007 巻 23, 2006 巻 22, 2005 巻 21, 2004 巻 20, 2003 巻 19, 2002 巻 18, 2001 巻 17, 2000 巻 16, 1999 巻 15, 1998 巻 14, 1997 巻 13, 1996 巻 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2018024397
pages 239-276

Evaluation of Nanocarrier-Based Dry Powder Formulations for Inhalation with Special Reference to Anti-Tuberculosis Drugs

Tulshidas S. Patil
School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Maharashtra, India
Ashwini Deshpande
School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Maharashtra, India
Pravin K. Shende
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, Maharashtra, India
Shirish Deshpande
School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Maharashtra, India
Ram Gaud
School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Maharashtra, India

要約

Pulmonary tuberculosis (TB) is a leading cause of death worldwide and is caused by the pathogen Mycobacterium tuberculosis (MTb). As treatment for TB, dry powders for inhalation (DPIs) are considered stable compared with nebulizers and metered dose inhalers and are suitable for high-dose formulations. Although extensive research has been done over the last two to three decades on nanocarrier-based DPIs for targeting MTb infection, none of the anti-TB DPI formulations have reached the market. Challenges in the proper assessment of nanocarrier-based DPIs due to the complexity of lungs is one of the reasons. In this review, the details of in vitro evaluation parameters of nanocarriers and nanocarrier-based DPIs along with their need and basic principles are discussed. Further, the thorough in vitro, ex vivo, and in vivo pharmacological evaluations, together with their procedures wherever required, are covered. The different evaluation parameters during process development, release specifications, and stability studies suggested by U.S. Food and Drug Administration Center for Drug Evaluation and Research to apply for new drug applications and abbreviated new drug applications of DPIs are also discussed. Lastly, the evaluation parameters for DPIs provided in European, United States, British, and Indian pharmacopeias are summarized.


Articles with similar content:

Nanosuspensions in Drug Delivery: Recent Advances, Patent Scenarios, and Commercialization Aspects
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 5
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan
Particulate Pulmonary Delivery Systems Containing Anti-Tuberculosis Agents
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.30, 2013, issue 4
Mradul Mohan, Imran Mohammad, Atul Kumar Agrawal, Sanketkumar M. Pandya, Amit Misra, Anuradha Gupta
Surviving a Site Audit: Tips for Good Clinical Practice in an Implant Trial
Journal of Long-Term Effects of Medical Implants, Vol.19, 2009, issue 3
Esther M.M. Van Lieshout, Stephanie M. Zielinski
Mechanophysical-Chemotherapy Combinations: A Dual Approach to Combat Cancer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 3
Suruchi S. Vasudev, Farhan Jalees Ahmad, Rabea Parveen, Sushama Talegaonkar, Zeenat Iqbal
Colloidal Carriers: A Rising Tool for Therapy of Tuberculosis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 4
Suresh P. Vyas, Manish K. Gupta, Swati Gupta, Pankaj Kumar