年間 6 号発行
ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X
Indexed in
Gastroretentive Drug Delivery Systems for Therapeutic Management of Peptic Ulcer
要約
A peptic ulcer, stomach ulcer, or gastric ulcer, also known as peptic ulcer disease (PUD), is a very common chronic disorder of the stomach which is mainly caused by damage or impairment of the stomach lining. Various factors such as pepsin, gastric acid, H. pylori, NSAIDs, prostaglandins, mucus, bicarbonate, and blood flow to mucosa play an important role in causing peptic ulcers. In this review article, our main focus is on some important gastroretentive drug delivery systems (GRDDS) (floating, bioadhesive, high density, swellable, raft forming, superporous hydrogel, and magnetic systems) which will be helpful in gastroretention of different dosage forms for treatment of peptic ulcer. GRDDS provides a mean for controlled release of compounds that are absorbed by active transport in the upper intestine. It also enables controlled delivery for paracellularly absorbed drugs without a decrease in bioavailability. The above approaches are specific for targeting and leading to a marked improvement in the quality of life for a large number of patients. In the future, it is expected that they will become of growing significance, finally leading to improved efficiencies of various types of pharmacotherapies.
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de Souza Maurício Palmeira Chaves, de Camargo Bruna Almeida Furquim, Spósito Larissa, Fortunato Giovanna Capaldi, Carvalho Gabriela Corrêa, Marena Gabriel Davi, Meneguin Andréia Bagliotti, Bauab Taís Maria, Chorilli Marlus, Highlighting the use of micro and nanoparticles based-drug delivery systems for the treatment of Helicobacter pylori infections, Critical Reviews in Microbiology, 47, 4, 2021. Crossref
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Shahzad Yasser, Ibrar Namra, Hussain Talib, Yousaf Abid Mehmood, Khan Ikram Ullah, Rizvi Syed A. A., Relevancy of Nizatidine’s Release from Floating Tablets with Viscosity of Various Cellulose Ethers, Sci, 3, 2, 2021. Crossref
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Shah Muhammad Raza, Imran Muhammad, Ullah Shafi, Designing of nanocarriers for enhancing drugs absorption through gastrointestinal tract, in Nanocarriers for Organ-Specific and Localized Drug Delivery, 2022. Crossref
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Das Uddipta , Wadhwa Pankaj , Singh Pankaj Kumar, Kalidindi Dheeraj Varma , Nagpal Kalpana, The Role of Polymers and Excipients for Better Gastric Retention of Captopril , Critical Reviews™ in Therapeutic Drug Carrier Systems, 39, 6, 2022. Crossref
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Cvijic Sandra, Ibric Svetlana, Parojcic Jelena, Djuris Jelena, An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems, Journal of Drug Delivery Science and Technology, 45, 2018. Crossref