年間 6 号発行
ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X
Indexed in
Recent Trends in Microbially and/or Enzymatically Driven Colon-Specific Drug Delivery Systems
要約
Colon-specific drug delivery systems have recently gained enormous importance for the delivery of a variety of therapeutic compounds. To deliver a drug molecule intact to the colon, the delivery system must pass through the upper part of the gastrointestinal tract without being degraded. Researchers have attempted various approaches in the formulation of colon-specific drug delivery systems. Among them, the most promising are the microbially and/or enzymatically driven drug delivery systems, consisting of biodegradable polymers (polysaccharides) and prodrugs. The major advantage of the microbially and/or enzymatically driven colon-specific drug delivery systems is that they can sense the arrival of the formulation in the colon and release the drug upon activation. This review familiarizes readers with the recent advancements in microbially and/or enzymatically driven colon-specific drug delivery systems, along with their in vitro and in vivo evaluation.
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Huang Yuanrui, Tian Rui, Hu Wenjing, Jia Yuntao, Zhang Jingqing, Jiang Huiming, Zhang Liangke, A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS, Carbohydrate Polymers, 92, 2, 2013. Crossref
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Maroni Alessandra, Del Curto Maria Dorly, Zema Lucia, Foppoli Anastasia, Gazzaniga Andrea, Film coatings for oral colon delivery, International Journal of Pharmaceutics, 457, 2, 2013. Crossref
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Patel Mayur Mahendrakumar, Colon targeting: an emerging frontier for oral insulin delivery, Expert Opinion on Drug Delivery, 10, 6, 2013. Crossref
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Marquez Ruiz Juan F., Kedziora Kinga, Pigott Maria, Keogh Brian, Windle Henry, Gavin Jason, Kelleher Dermot P., Gilmer John F., A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib, Bioorganic & Medicinal Chemistry Letters, 23, 6, 2013. Crossref
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Hartzell Annette L., Maldonado-Gómez María X., Yang Junyi, Hutkins Robert W., Rose Devin J., In vitro digestion and fermentation of 5-formyl-aminosailcylate-inulin: A potential prodrug of 5-aminosalicylic acid, Bioactive Carbohydrates and Dietary Fibre, 2, 1, 2013. Crossref
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Patel Mayur M, Getting into the colon: approaches to target colorectal cancer, Expert Opinion on Drug Delivery, 11, 9, 2014. Crossref
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Palugan Luca, Cerea Matteo, Zema Lucia, Gazzaniga Andrea, Maroni Alessandra, Coated pellets for oral colon delivery, Journal of Drug Delivery Science and Technology, 25, 2015. Crossref
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Patel Mayur Mahendrakumar, Drug Delivery: Oral Colon-Specific, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2015. Crossref
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Akhgari Abbas, Role of Polysaccharides in Colon-Specific Drug Delivery, Jundishapur Journal of Natural Pharmaceutical Products, 10, 3, 2015. Crossref
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Patel Mayur M., Micro/nano-particulate drug delivery systems: a boon for the treatment of inflammatory bowel disease, Expert Opinion on Drug Delivery, 13, 6, 2016. Crossref
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Patel Mayur M., Formulation and development of di-dependent microparticulate system for colon-specific drug delivery, Drug Delivery and Translational Research, 7, 2, 2017. Crossref
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Sinhmar Gurpreet Kaur, Shah Neel N., Rawal Shruti U., Chokshi Nimitt V., Khatri Hiren N., Patel Bhoomika M., Patel Mayur M., Surface engineered lipid nanoparticle-mediated site-specific drug delivery system for the treatment of inflammatory bowel disease, Artificial Cells, Nanomedicine, and Biotechnology, 46, sup2, 2018. Crossref
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Wen Peng, Hu Teng-Gen, Li Lin, Zong Min-Hua, Wu Hong, A colon-specific delivery system for quercetin with enhanced cancer prevention based on co-axial electrospinning, Food & Function, 9, 11, 2018. Crossref
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Wen Peng, Hu Teng-Gen, Wen Yan, Linhardt Robert J., Zong Min-Hua, Zou Yu-Xiao, Wu Hong, Targeted delivery of phycocyanin for the prevention of colon cancer using electrospun fibers, Food & Function, 10, 4, 2019. Crossref
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Casati Federica, Melocchi Alice, Moutaharrik Saliha, Uboldi Marco, Foppoli Anastasia, Maroni Alessandra, Zema Lucia, Neut Christel, Siepmann Florence, Siepmann Juergen, Gazzaniga Andrea, Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches, International Journal of Molecular Sciences, 21, 6, 2020. Crossref
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Wang Hongdi, Zhang Xiaotong, Zhu Wei, Jiang Yanbin, Zhang Zhibing, Self-Assembly of Zein-Based Microcarrier System for Colon-Targeted Oral Drug Delivery, Industrial & Engineering Chemistry Research, 57, 38, 2018. Crossref
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Vinchhi Preksha, Patel Mayur M., Triumph against cancer: invading colorectal cancer with nanotechnology, Expert Opinion on Drug Delivery, 18, 9, 2021. Crossref
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Saphier Sigal, Haft Avital, Margel Shlomo, Bacterial Reduction as Means for Colonic Drug Delivery: Can Other Chemical Groups Provide an Alternative to the Azo Bond?, Journal of Medicinal Chemistry, 55, 23, 2012. Crossref
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Wei Yun-shan, Feng Kun, Li Shu-fang, Hu Teng-gen, Linhardt Robert J., Zong Min-hua, Wu Hong, Oral fate and stabilization technologies of lactoferrin: a systematic review, Critical Reviews in Food Science and Nutrition, 62, 23, 2022. Crossref