ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Therapeutic Drug Carrier Systems
インパクトファクター: 2.9 5年インパクトファクター: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN 印刷: 0743-4863
ISSN オンライン: 2162-660X

巻:
巻 36, 2019 巻 35, 2018 巻 34, 2017 巻 33, 2016 巻 32, 2015 巻 31, 2014 巻 30, 2013 巻 29, 2012 巻 28, 2011 巻 27, 2010 巻 26, 2009 巻 25, 2008 巻 24, 2007 巻 23, 2006 巻 22, 2005 巻 21, 2004 巻 20, 2003 巻 19, 2002 巻 18, 2001 巻 17, 2000 巻 16, 1999 巻 15, 1998 巻 14, 1997 巻 13, 1996 巻 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i1.20
pages 47-99

Gastroretentive Floating Drug-Delivery Systems: A Critical Review

Udaya Kotreka
Boehringer Ingelheim Roxane Lboratories, Inc
Moji Christianah Adeyeye
Department of Biopharmaceutical Sciences College of Pharmacy, Roosevelt University, Schaumburg, IL, USA

要約

The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. To overcome this drawback and to maximize the oral absorption of these drugs, gastroretentive systems such as mucoadhesive, high-density, expandable, and floating systems have been developed. These systems provide controlled delivery of drugs with prolonged gastric residence time. However, in humans, differences in various physiological and biological factors can affect the gastric residence time and drug-delivery behavior from gastroretentive systems. Some floating drugdelivery systems (FDDS) have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses on various physiological considerations for development of FDDS, and highlights recent technological developments including new dosage forms and their production techniques (e.g., holt-melt extrusion, melt pelletization, and pulsed plasma-irradiation processes). Alternatives to the existing in vitro compendial methods for evaluating floating dosage forms will be discussed, and a critical analysis of the existing literature on FDDS, identifying the potential areas for future research, is provided.


Articles with similar content:

Extrusion-Spheronization: Process Variables and Characterization
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 3
A. Agarwal, Gurpreet Singh, Vivek Ranjan Sinha, M. K. Agrawal, D. Ghai
A Review of the Application of Lipid-Based Systems in Systemic, Dermal/ Transdermal, and Ocular Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 6
Kishor M. Wasan, Pavel Gershkovich, Cheri A. Barta
Oral Colon-Specific Drug Delivery of Protein and Peptide Drugs
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 1
Ruchita V. Kumar, Sanjay Singh, Vivek Ranjan Sinha, J. R. Bhinge, Asmita Singh, Rachana Kumria
Osmotic Pumps in Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 6
Sachin Arora, Sanjay Garg, Rajan K. Verma
The Colon as a Possible Target for Orally Administered Peptide and Protein Drugs
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.19, 2002, issue 6
Abraham Rubinstein, Susan Moody Haupt