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Critical Reviews™ in Therapeutic Drug Carrier Systems

年間 6 号発行

ISSN 印刷: 0743-4863

ISSN オンライン: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Polymer-Based Drug Delivery Systems for Cancer

巻 35, 発行 6, 2018, pp. 521-553
DOI: 10.1615/CritRevTherDrugCarrierSyst.2018021124
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要約

The standard treatment for metastatic cancer is generally a combination of chemotherapy, surgery, and radiotherapy. Since there are few specific chemotherapeutics approved by the US Food and Drug Administration, systemic chemotherapy is widely employed in the hopes of destroying rapidly dividing cancer cells before doing irreversible damage to the human body. Because of the nature of traditional chemotherapeutics, systemic treatment is associated with various side effects, such as nausea, dysphoria, vomiting, and pain, and long-term, irreversible damage to major organs, such as the kidney and heart. As life expectancy increases, so has the need for reliable cancer therapy that spares or prevents damage to functional healthy organs. One method is to precisely deliver drugs into specific tumor cells and tissues. Polymers have been characterized as favorable systems to deliver drugs with tunable pharmacokinetics, circulation times, biocompatibility, and biodegradability. Here, various types of polymers, modified as drug delivery systems for targeting cancer, and targeting behaviors of polymer-based carriers will be discussed.

キーワード: therapy, apoptosis
によって引用された
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