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Critical Reviews™ in Immunology
インパクトファクター: 1.404 5年インパクトファクター: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v22.i4.40
22 pages

Autoimmunity to Glutamate Receptors in the Central Nervous System

Lorise C. Gahring
Salt Lake City VA-GRECC and University of Utah School of Medicine, Departments of Internal Medicine and Neurobiology and Anatomy, 2C110, 50 North Medical Drive, Salt Lake City, UT 84132
Scott W. Rogers
Salt Lake City VA-GRECC and University of Utah School of Medicine, Departments of Internal Medicine and Neurobiology and Anatomy, 2C110, 50 North Medical Drive, Salt Lake City, UT 84132

要約

Autoimmunity to glutamate receptors (GluR) of the central nervous system offers an attractive model to begin the experimental dissection of the etiology of immune-related neurodegenerative diseases. Here we discuss the known mechanisms of generating autoimmunity to different members of the GluR neurotransmitter receptor family within the unique environment of the brain and how autoantibody-receptor interactions contribute to abnormal neurotransmission and eventually pathology.


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