年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
Functions of Granulocyte-Macrophage Colony-Stimulating Factor
要約
GM-CSF was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells. Apart from its physiological role in the control of alveolar macrophage development, it now appears more likely that its major role lies in its ability to govern the properties of the more mature myeloid cells of the granulocyte and macrophage lineages, particularly during host defence and inflammatory reactions. Recent evidence is summarized below for a key role for GM-CSF in inflammatory and autoimmune diseases, making it therefore worthy of consideration for targeting. Such evidence includes disease exacerbation following its administration and amelioration of disease in animal models by GM-CSF gene targeting or by anti-GM-CSF antibody blockade. This review summarizes the evidence supporting a major role for GM-CSF in inflammation and autoimmunity and its functions as major regulator governing granulocyte and macrophage lineage populations at all stages of maturation.
-
Hemachandra Reddy P., Manczak Maria, Zhao Wei, Nakamura Kazuhiro, Bebbington Christopher, Yarranton Geoffrey, Mao Peizhong, Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimerâs Disease and multiple sclerosis, Journal of Neurochemistry, 111, 6, 2009. Crossref
-
Conti Lucia, Cardone Marco, Varano Barbara, Puddu Patrizia, Belardelli Filippo, Gessani Sandra, Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes, European Journal of Immunology, 38, 3, 2008. Crossref
-
Fu Jun, Sha Beverly E, Thomas Larry L, HIV-1–Infected Peripheral Blood Mononuclear Cells Enhance Neutrophil Survival and HLA-DR Expression Via Increased Production of GM-CSF: Implications for HIV-1 Infection, JAIDS Journal of Acquired Immune Deficiency Syndromes, 56, 1, 2011. Crossref
-
Martinez-Moczygemba Margarita, Huston David P., Immune Dysregulation in the Pathogenesis of Pulmonary Alveolar Proteinosis, Current Allergy and Asthma Reports, 10, 5, 2010. Crossref
-
Jinushi Masahisa, Nakazaki Yukoh, Dougan Michael, Carrasco Daniel R., Mihm Martin, Dranoff Glenn, MFG-E8–mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF, Journal of Clinical Investigation, 117, 7, 2007. Crossref
-
Hamilton John A., Colony-stimulating factors in inflammation and autoimmunity, Nature Reviews Immunology, 8, 7, 2008. Crossref
-
Nguyen Minh C., Tu Guang Huan, Koprivnikar Kathryn E., Gonzalez-Edick Melissa, Jooss Karin U., Harding Thomas C., Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy, Cancer Immunology, Immunotherapy, 59, 9, 2010. Crossref
-
Lanfranconi S., Locatelli F., Corti S., Candelise L., Comi G. P., Baron P. L., Strazzer S., Bresolin N., Bersano A., Growth factors in ischemic stroke, Journal of Cellular and Molecular Medicine, 15, 8, 2011. Crossref
-
Trapnell Bruce C, Carey Brenna C, Uchida Kanji, Suzuki Takuji, Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages, Current Opinion in Immunology, 21, 5, 2009. Crossref
-
Dittel Bonnie N., CD4 T cells: Balancing the coming and going of autoimmune-mediated inflammation in the CNS, Brain, Behavior, and Immunity, 22, 4, 2008. Crossref
-
Szeliga Jacek, Daniel D. Sundarsingh, Yang Ching-Hui, Sever-Chroneos Zvjezdana, Jagannath Chinnaswamy, Chroneos Zissis C., Granulocyte–macrophage colony stimulating factor-mediated innate responses in tuberculosis, Tuberculosis, 88, 1, 2008. Crossref
-
Coomes Stephanie M., Hubbard Leah L. N., Moore Bethany B., Impaired pulmonary immunity post-bone marrow transplant, Immunologic Research, 50, 1, 2011. Crossref
-
Amiri Sara, Ghazanfari Tooba, Yaraee Roya, Salimi Hassan, Ebtekar Massoumeh, Shams Jalaleddin, Ghasemi Hassan, Pourfarzam Shahryar, Moin Athar, Sharifnia Zarin, Soroush Mohammad R., Faghihzadeh Soghrat, Hassan Zuhair M., Serum levels of GM-CSF 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study, International Immunopharmacology, 9, 13-14, 2009. Crossref
-
Egea Laia, Hirata Yoshihiro, Kagnoff Martin F, GM-CSF: a role in immune and inflammatory reactions in the intestine, Expert Review of Gastroenterology & Hepatology, 4, 6, 2010. Crossref
-
Cook Andrew D., Turner Amanda L., Braine Emma L., Pobjoy Jarrad, Lenzo Jason C., Hamilton John A., Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis, Arthritis & Rheumatism, 63, 8, 2011. Crossref
-
Hercus Timothy R., Thomas Daniel, Guthridge Mark A., Ekert Paul G., King-Scott Jack, Parker Michael W., Lopez Angel F., The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease, Blood, 114, 7, 2009. Crossref
-
Lederle Wiltrud, Depner Sofia, Schnur Sabine, Obermueller Eva, Catone Nicola, Just Alexandra, Fusenig Norbert E., Mueller Margareta M., IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines, International Journal of Cancer, 128, 12, 2011. Crossref
-
Brochériou Isabelle, Maouche Seraya, Durand Hervé, Braunersreuther Vincent, Le Naour Gilles, Gratchev Alexei, Koskas Fabien, Mach François, Kzhyshkowska Julia, Ninio Ewa, Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: Implication in atherosclerosis, Atherosclerosis, 214, 2, 2011. Crossref
-
Shi Xiaojun, Zhang Xinji, Li Jinlong, Guo Fangfang, Hu Zhiming, Jing Yuming, Bai Li, Chen Sansan, Wan Pei, Wang Fei, Gao Jimin, Tan Wanlong, Sequential administration of GM-CSF and IL-2 surface-modified MB49 cells vaccines against the metastatic bladder cancer, Urologic Oncology: Seminars and Original Investigations, 31, 6, 2013. Crossref
-
Li H.X., Sze S.C.W., Tong Y., Ng T.B., Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes, Journal of Ethnopharmacology, 123, 2, 2009. Crossref
-
Jeong Hyun-Ja, Shin Seung-Youp, Oh Hyun-A, Kim Min-Ho, Cho Joong-Saeng, Kim Hyung-Min, IL-32 up-regulation is associated with inflammatory cytokine production in allergic rhinitis, The Journal of Pathology, 224, 4, 2011. Crossref
-
Puljic Ruzica, Benediktus Ewald, Plater-Zyberk Christine, Baeuerle Patrick A., Szelenyi Stefan, Brune Kay, Pahl Andreas, Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF, European Journal of Pharmacology, 557, 2-3, 2007. Crossref
-
Conti Lucia, Gessani Sandra, GM-CSF in the generation of dendritic cells from human blood monocyte precursors: Recent advances, Immunobiology, 213, 9-10, 2008. Crossref
-
Starnes Linda Marie, Sorrentino Antonio, Pelosi Elvira, Ballarino Monica, Morsilli Ornella, Biffoni Mauro, Santoro Simona, Felli Nadia, Castelli Germana, De Marchis Maria Laura, Mastroberardino Gianfranco, Gabbianelli Marco, Fatica Alessandro, Bozzoni Irene, Nervi Clara, Peschle Cesare, NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression, Blood, 114, 9, 2009. Crossref
-
Hansen Guido, Hercus Timothy R., McClure Barbara J., Stomski Frank C., Dottore Mara, Powell Jason, Ramshaw Hayley, Woodcock Joanna M., Xu Yibin, Guthridge Mark, McKinstry William J., Lopez Angel F., Parker Michael W., The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation, Cell, 134, 3, 2008. Crossref
-
Sheikh Nadeem A., Petrylak Daniel, Kantoff Philip W., dela Rosa Corazon, Stewart Frances P., Kuan Ling-Yu, Whitmore James B., Trager James B., Poehlein Christian H., Frohlich Mark W., Urdal David L., Sipuleucel-T immune parameters correlate with survival: an analysis of the randomized phase 3 clinical trials in men with castration-resistant prostate cancer, Cancer Immunology, Immunotherapy, 62, 1, 2013. Crossref
-
Michelini Flavia M., Zorrilla Pilar, Robello Carlos, Alché Laura E., Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog, Bioorganic & Medicinal Chemistry, 21, 2, 2013. Crossref
-
Paquet Joseph, Goebel Jean-Christophe, Delaunay Camille, Pinzano Astrid, Grossin Laurent, Cournil-Henrionnet Christel, Gillet Pierre, Netter Patrick, Jouzeau Jean-Yves, Moulin David, Cytokines profiling by multiplex analysis in experimental arthritis: which pathophysiological relevance for articular versus systemic mediators?, Arthritis Research & Therapy, 14, 2, 2012. Crossref
-
Hayashi Kozaburo, Hooper Laura C., Okuno Toshiomi, Takada Yuichiro, Hooks John J., Inhibition of HSV-1 by chemoattracted neutrophils: supernatants of corneal epithelial cells (HCE) and macrophages (THP-1) treated with virus components chemoattract neutrophils (PMN), and supernatants of PMN treated with these conditioned media inhibit viral growth, Archives of Virology, 157, 7, 2012. Crossref
-
Broughton Sophie E., Dhagat Urmi, Hercus Timothy R., Nero Tracy L., Grimbaldeston Michele A., Bonder Claudine S., Lopez Angel F., Parker Michael W., The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling, Immunological Reviews, 250, 1, 2012. Crossref
-
Mentor-Marcel Roycelynn A., Bobe Gerd, Sardo Christine, Wang Li-Shu, Kuo Chieh-Ti, Stoner Gary, Colburn Nancy H., Plasma Cytokines as Potential Response Indicators to Dietary Freeze-Dried Black Raspberries in Colorectal Cancer Patients, Nutrition and Cancer, 64, 6, 2012. Crossref
-
Hercus Timothy R., Broughton Sophie E., Ekert Paul G., Ramshaw Hayley S., Perugini Michelle, Grimbaldeston Michele, Woodcock Joanna M., Thomas Daniel, Pitson Stuart, Hughes Timothy, D'Andrea Richard J., Parker Michael W., Lopez Angel F., The GM-CSF receptor family: Mechanism of activation and implications for disease, Growth Factors, 30, 2, 2012. Crossref
-
Hayashi Kozaburo, Hooper Laura C., Shimomura Yoshikazu, Who Pays the Toll for Solving the Enigma of Corneal Herpes?, Cornea, 32, Supplement 1, 2013. Crossref
-
Jain Preeti, Singh Rani, Saxena V.K., Singh K.B., Ahmed K.A., Tiwari A.K., Saxena M., Sundaresan N.R., In vitro rapid clearance of infectious bursal disease virus in peripheral blood mononuclear cells of chicken lines divergent for antibody response might be related to the enhanced expression of proinflammatory cytokines, Research in Veterinary Science, 95, 3, 2013. Crossref
-
Rostami Abdolmohamad, Ciric Bogoljub, Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination, Journal of the Neurological Sciences, 333, 1-2, 2013. Crossref
-
Zhang Hong-Liang, Zheng Xiang-Yu, Zhu Jie, Th1/Th2/Th17/Treg cytokines in Guillain–Barré syndrome and experimental autoimmune neuritis, Cytokine & Growth Factor Reviews, 24, 5, 2013. Crossref
-
Bedoya Simone Kennedy, Lam Brandon, Lau Kenneth, Larkin Joseph, Th17 Cells in Immunity and Autoimmunity, Clinical and Developmental Immunology, 2013, 2013. Crossref
-
Hercus Timothy R., Dhagat Urmi, Kan Winnie L.T., Broughton Sophie E., Nero Tracy L., Perugini Michelle, Sandow Jarrod J., D’Andrea Richard J., Ekert Paul G., Hughes Timothy, Parker Michael W., Lopez Angel F., Signalling by the βc family of cytokines, Cytokine & Growth Factor Reviews, 24, 3, 2013. Crossref
-
van Nieuwenhuijze Annemarie, Koenders Marije, Roeleveld Debbie, Sleeman Matthew A., van den Berg Wim, Wicks Ian P., GM-CSF as a therapeutic target in inflammatory diseases, Molecular Immunology, 56, 4, 2013. Crossref
-
Bilgici Birsen, Ecemis Gulcin C., Tuncel Ozgur K., Bayrak Ilkay K., Kan Elif K., Atmaca Aysegul, VEGF and GM-CSF levels in nodular thyroid diseases, Endocrine, 45, 1, 2014. Crossref
-
Brennan Frank R., MAbs Targeting Soluble Mediators in Phase 1 and 2 Clinical Studies Immunological Disorders, in Handbook of Therapeutic Antibodies, 2014. Crossref
-
Chalouhi Nohra, Theofanis Thana, Starke Robert M., Zanaty Mario, Jabbour Pascal, Dooley Sarah A., Hasan David, Potential Role of Granulocyte–Monocyte Colony-Stimulating Factor in the Progression of Intracranial Aneurysms, DNA and Cell Biology, 34, 1, 2015. Crossref
-
Zhu Yong-tong, Zhao Zhen, Fu Xin-yang, Luo Yang, Lei Cheng-yong, Chen Wei, Li Fei, Pang Shi-yu, Chen San-san, Tan Wan-long, The granulocyte macrophage–colony stimulating factor surface modified MB49 bladder cancer stem cells vaccine against metastatic bladder cancer, Stem Cell Research, 13, 1, 2014. Crossref
-
Aliper Alexander M., Frieden‐Korovkina Victoria P., Buzdin Anton, Roumiantsev Sergey A., Zhavoronkov Alex, A role for G‐CSF and GM‐CSF in nonmyeloid cancers, Cancer Medicine, 3, 4, 2014. Crossref
-
NAKAGAKI Kazuhide, NUNOMURA Yuka, UCHIDA Kanji, NAKATA Koh, TAZAWA Ryushi, Up-Regulation of Cluster of Differentiation (CD) 11b Expression on the Surface of Canine Granulocytes with Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Journal of Veterinary Medical Science, 76, 8, 2014. Crossref
-
Ashhurst Thomas Myles, Vreden Caryn van, Niewold Paula, King Nicholas Jonathan Cole, The plasticity of inflammatory monocyte responses to the inflamed central nervous system, Cellular Immunology, 291, 1-2, 2014. Crossref
-
Colin Sophie, Chinetti-Gbaguidi Giulia, Staels Bart, Macrophage phenotypes in atherosclerosis, Immunological Reviews, 262, 1, 2014. Crossref
-
Kumar Prabhakaran, Subramaniyam Ganesan, Molecular underpinnings of Th17 immune-regulation and their implications in autoimmune diabetes, Cytokine, 71, 2, 2015. Crossref
-
Aumailley Lucie, Dubois Marie Julie, Garand Chantal, Marette André, Lebel Michel, Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase, Experimental Gerontology, 72, 2015. Crossref
-
Avci A. Berkant, Feist Eugen, Burmester Gerd-R., A Promising Target in Rheumatoid Arthritis Treatment: Granulocyte-Macrophage Colony-Stimulating Factor, Current Treatment Options in Rheumatology, 1, 4, 2015. Crossref
-
Dorovini-Zis Katerina, Easton Alexander, Inflammatory Mediators and the Blood-Brain Barrier, in The Blood-Brain Barrier in Health and Disease, Volume One, 2015. Crossref
-
Bhattacharya Palash, Budnick Isadore, Singh Medha, Thiruppathi Muthusamy, Alharshawi Khaled, Elshabrawy Hatem, Holterman Mark J., Prabhakar Bellur S., Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy, Journal of Interferon & Cytokine Research, 35, 8, 2015. Crossref
-
Shiomi Aoi, Usui Takashi, Pivotal Roles of GM-CSF in Autoimmunity and Inflammation, Mediators of Inflammation, 2015, 2015. Crossref
-
Mathias Brittany, Szpila Benjamin E., Moore Frederick A., Efron Philip A., Moldawer Lyle L., A Review of GM-CSF Therapy in Sepsis, Medicine, 94, 50, 2015. Crossref
-
Ciric Bogoljub, Rasouli Javad, Rostami Abdolmohamad, Granulocyte-Macrophage Colony-Stimulating Factor in Central Nervous System Autoimmunity, in Multiple Sclerosis, 2016. Crossref
-
Hamilton John A, GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential, Expert Review of Clinical Immunology, 11, 4, 2015. Crossref
-
Maksaereekul Saipiroon, Dubie Robert A., Shen Xiaoying, Kieu Hung, Dean Gregg A., Sparger Ellen E., Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-α plasmids preserves global CD4 T lymphocyte function after challenge with FIV, Vaccine, 27, 28, 2009. Crossref
-
Spengler Mark, Adler Michael, Niemeyer Christof M., Highly sensitive ligand-binding assays in pre-clinical and clinical applications: immuno-PCR and other emerging techniques, The Analyst, 140, 18, 2015. Crossref
-
Ramaglia Luca, Di Spigna Gaetano, Capece Gabriele, Sbordone Carolina, Salzano Salvatore, Postiglione Loredana, Differentiation, apoptosis, and GM-CSF receptor expression of human gingival fibroblasts on a titanium surface treated by a dual acid-etched procedure, Clinical Oral Investigations, 19, 9, 2015. Crossref
-
Kostic Milos, Stojanovic Ivana, Marjanovic Goran, Zivkovic Nikola, Cvetanovic Ana, Deleterious versus protective autoimmunity in multiple sclerosis, Cellular Immunology, 296, 2, 2015. Crossref
-
Scaldaferri Franco, Vetrano Stefania, Mesenchymal Stem Cells in IBD: unMaSCing Their Therapeutic Mechanisms, Digestive Diseases and Sciences, 60, 7, 2015. Crossref
-
Vogel Daphne Y. S., Kooij Gijs, Heijnen Priscilla D. A. M., Breur Marjolein, Peferoen Laura A. N., van der Valk Paul, de Vries Helga E., Amor Sandra, Dijkstra Christine D., GM-CSF promotes migration of human monocytes across the blood brain barrier, European Journal of Immunology, 45, 6, 2015. Crossref
-
Na Yi Rang, Gu Gyo Jung, Jung Daun, Kim Young Won, Na Juri, Woo Jin Sun, Cho Joo Youn, Youn Hyewon, Seok Seung Hyeok, GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism, The Journal of Immunology, 197, 10, 2016. Crossref
-
Chen Gwo-Hsiao, Teitz-Tennenbaum Seagal, Neal Lori M., Murdock Benjamin J., Malachowski Antoni N., Dils Anthony J., Olszewski Michal A., Osterholzer John J., Local GM-CSF–Dependent Differentiation and Activation of Pulmonary Dendritic Cells and Macrophages Protect against Progressive Cryptococcal Lung Infection in Mice, The Journal of Immunology, 196, 4, 2016. Crossref
-
Rajagopalan Govindarajan, Mangalam Ashutosh K., Sen Moon M., Cheng Shen, Kudva Yogish C., David Chella S., Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans, Autoimmunity, 40, 3, 2007. Crossref
-
Sadeghi Kambis, Wisgrill Lukas, Wessely Isabelle, Diesner Susanne C., Schüller Simone, Dürr Celia, Heinle Armando, Sachet Monika, Pollak Arnold, Förster-Waldl Elisabeth, Spittler Andreas, Zamboni Dario S., GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes, PLOS ONE, 11, 10, 2016. Crossref
-
Bonomo Adriana, Monteiro Ana Carolina, Gonçalves-Silva Triciana, Cordeiro-Spinetti Eric, Galvani Rômulo Gonçalves, Balduino Alex, A T Cell View of the Bone Marrow, Frontiers in Immunology, 7, 2016. Crossref
-
Papp Stefanie, Moderzynski Kristin, Rauch Jessica, Heine Liza, Kuehl Svenja, Richardt Ulricke, Mueller Heidelinde, Fleischer Bernhard, Osterloh Anke, Makepeace Benjamin L, Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells, PLOS Neglected Tropical Diseases, 10, 8, 2016. Crossref
-
Kasahara Shinji, Jhingran Anupam, Dhingra Sourabh, Salem Anand, Cramer Robert A., Hohl Tobias M., Role of Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Regulating Neutrophil Antifungal Activity and the Oxidative Burst During Respiratory Fungal Challenge, Journal of Infectious Diseases, 213, 8, 2016. Crossref
-
Katz Sándor, Zsiros Viktória, Dóczi Nikolett, Szabó Arnold, Biczó Ádám, Kiss Anna L., GM-CSF and GM-CSF receptor have regulatory role in transforming rat mesenteric mesothelial cells into macrophage-like cells, Inflammation Research, 65, 10, 2016. Crossref
-
Li Zhanzhan, Mao Ruoyu, Teng Da, Hao Ya, Chen Huixian, Wang Xiumin, Wang Xiao, Yang Na, Wang Jianhua, Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus, Scientific Reports, 7, 1, 2017. Crossref
-
Gieryng Anna, Pszczolkowska Dominika, Walentynowicz Kacper A, Rajan Wenson D, Kaminska Bozena, Immune microenvironment of gliomas, Laboratory Investigation, 97, 5, 2017. Crossref
-
Dey Raja, Ji Kunmei, Liu Zhigang, Chen Lin, Xu Wenqing, A Cytokine–Cytokine Interaction in the Assembly of Higher-Order Structure and Activation of the Interleukine-3:Receptor Complex, PLoS ONE, 4, 4, 2009. Crossref
-
Ifergan Igal, Davidson Todd S., Kebir Hania, Xu Dan, Palacios-Macapagal Daphne, Cann Jennifer, Rodgers Jane M., Hunter Zoe N., Pittet Camille L., Beddow Sara, Jones Clare A., Prat Alexandre, Sleeman Matthew A., Miller Stephen D., Targeting the GM-CSF receptor for the treatment of CNS autoimmunity, Journal of Autoimmunity, 84, 2017. Crossref
-
Chen Yaqiong, Zhao Zhi, Chen Yu, Lv Zhonglin, Ding Xin, Wang Renxi, Xiao He, Hou Chunmei, Shen Beifen, Feng Jiannan, Guo Renfeng, Li Yan, Peng Hui, Han Gencheng, Chen Guojiang, An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer, Scientific Reports, 7, 1, 2017. Crossref
-
Kiku Yoshio, Ozawa Tomomi, Takahashi Hideyuki, Kushibiki Shiro, Inumaru Shigeki, Shingu Hiroyuki, Nagasawa Yuya, Watanabe Atsushi, Hata Eiji, Hayashi Tomohito, Effect of intramammary infusion of recombinant bovine GM-CSF and IL-8 on CMT score, somatic cell count, and milk mononuclear cell populations in Holstein cows with Staphylococcus aureus subclinical mastitis, Veterinary Research Communications, 41, 3, 2017. Crossref
-
Noack Mélissa, Miossec Pierre, Selected cytokine pathways in rheumatoid arthritis, Seminars in Immunopathology, 39, 4, 2017. Crossref
-
Burkhardt Jana, Kirsten Holger, Wolfram Grit, Quente Elfi, Ahnert Peter, Differential allelic expression of IL13 and CSF2 genes associated with asthma, Genetics and Molecular Biology, 35, 3, 2012. Crossref
-
Cheung Tommy Tsang, McInnes Iain B., Future therapeutic targets in rheumatoid arthritis?, Seminars in Immunopathology, 39, 4, 2017. Crossref
-
Ballinger Megan N., Hubbard Leah L. N., McMillan Tracy R., Toews Galen B., Peters-Golden Marc, Paine Robert, Moore Bethany B., Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation, American Journal of Physiology-Lung Cellular and Molecular Physiology, 295, 1, 2008. Crossref
-
Prell R.A., Tarrant J.M., Cytokines: Role in Homeostasis and Disease States, in Comprehensive Toxicology, 2018. Crossref
-
Tahmasebinia Foozhan, Pourgholaminejad Arash, The role of Th17 cells in auto-inflammatory neurological disorders, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 79, 2017. Crossref
-
Thatcher Thomas H., Benson Randi P., Phipps Richard P., Sime Patricia J., High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function, American Journal of Physiology-Lung Cellular and Molecular Physiology, 295, 3, 2008. Crossref
-
Sharma Mahima, Dash Pujarini, Sahoo Pramod K., Dixit Aparna, Th2-biased immune response and agglutinating antibodies generation by a chimeric protein comprising OmpC epitope (323–336) of Aeromonas hydrophila and LTB, Immunologic Research, 66, 1, 2018. Crossref
-
Na Yi Rang, Hong Ji Hye, Lee Min Yong, Jung Jae Hun, Jung Daun, Kim Young Won, Son Dain, Choi Murim, Kim Kwang Pyo, Seok Seung Hyeok, Proteomic Analysis Reveals Distinct Metabolic Differences Between Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Macrophage Colony Stimulating Factor (M-CSF) Grown Macrophages Derived from Murine Bone Marrow Cells*, Molecular & Cellular Proteomics, 14, 10, 2015. Crossref
-
Armani Chiara, Catalani Elisabetta, Balbarini Alberto, Bagnoli Paola, Cervia Davide, Expression, pharmacology, and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages, Journal of Leukocyte Biology, 81, 3, 2007. Crossref
-
Huizinga T. W. J., Batalov A., Stoilov R., Lloyd E., Wagner T., Saurigny D., Souberbielle B., Esfandiari E., Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis, Arthritis Research & Therapy, 19, 1, 2017. Crossref
-
Meshkibaf Shahab, William Gower Mark, Dekaban Gregory A., Ouk Kim Sung, G-CSF preferentially supports the generation of gut-homing Gr-1highmacrophages in M-CSF-treated bone marrow cells, Journal of Leukocyte Biology, 96, 4, 2014. Crossref
-
Nicol Louise S.C., Thornton Peter, Hatcher Jon P., Glover Colin P., Webster Carl I., Burrell Matthew, Hammett Kessia, Jones Clare A., Sleeman Matthew A., Billinton Andrew, Chessell Iain, Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain, Pain, 159, 3, 2018. Crossref
-
Yu Shuangjiang, He Chaoliang, Chen Xuesi, Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics-Based Combination Antitumor Therapy, Macromolecular Bioscience, 18, 12, 2018. Crossref
-
Fleetwood Andrew J., Dinh Hang, Cook Andrew D., Hertzog Paul J, Hamilton John A., GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling, Journal of Leukocyte Biology, 86, 2, 2009. Crossref
-
Chakrabarti Subhadeep, Chan Carmen K., Jiang Yanyan, Davidge Sandra T., Neuronal nitric oxide synthase regulates endothelial inflammation, Journal of Leukocyte Biology, 91, 6, 2012. Crossref
-
Furuya Makiko Yashiro, Asano Tomoyuki, Sumichika Yuya, Sato Shuzo, Kobayashi Hiroko, Watanabe Hiroshi, Suzuki Eiji, Kozuru Hideko, Yatsuhashi Hiroshi, Koga Tomohiro, Ohira Hiromasa, Sekine Hideharu, Kawakami Atsushi, Migita Kiyoshi, Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils, Arthritis Research & Therapy, 20, 1, 2018. Crossref
-
Dhagat Urmi, Hercus Timothy R., Broughton Sophie E., Nero Tracy L., Cheung Tung Shing Karen S., Barry Emma F., Thomson Christy A., Bryson Steve, Pai Emil F., McClure Barbara J., Schrader John W., Lopez Angel F., Parker Michael W., The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities, mAbs, 2018. Crossref
-
Burmester Gerd R., McInnes Iain B., Kremer Joel M., Miranda Pedro, Vencovský Jiří, Godwood Alex, Albulescu Marius, Michaels M. Alex, Guo Xiang, Close David, Weinblatt Michael, Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody, Arthritis & Rheumatology, 70, 5, 2018. Crossref
-
Halstead E. Scott, Umstead Todd M., Davies Michael L., Kawasawa Yuka Imamura, Silveyra Patricia, Howyrlak Judie, Yang Linlin, Guo Weichao, Hu Sanmei, Hewage Eranda Kurundu, Chroneos Zissis C., GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization, Respiratory Research, 19, 1, 2018. Crossref
-
Wu Un-In, Olivier Kenneth N, Kuhns Douglas B, Fink Danielle L, Sampaio Elizabeth P, Zelazny Adrian M, Shallom Shamira J, Marciano Beatriz E, Lionakis Michail S, Holland Steven M, Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production, Open Forum Infectious Diseases, 6, 12, 2019. Crossref
-
Lacey Derek C., Achuthan Adrian, Fleetwood Andrew J., Dinh Hang, Roiniotis John, Scholz Glen M., Chang Melody W., Beckman Sandra K., Cook Andrew D., Hamilton John A., Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models, The Journal of Immunology, 188, 11, 2012. Crossref
-
Nagaratnam Nages, Nagaratnam Kujan, Cheuk Gary, Blood Disorders in the Elderly, in Diseases in the Elderly, 2016. Crossref
-
Pazdrak Konrad, Young Travis W., Straub Christof, Stafford Susan, Kurosky Alexander, Priming of Eosinophils by GM-CSF Is Mediated by Protein Kinase CβII-Phosphorylated L-Plastin, The Journal of Immunology, 186, 11, 2011. Crossref
-
Ponomarev Eugene D., Shriver Leah P., Maresz Katarzyna, Pedras-Vasconcelos Joao, Verthelyi Daniela, Dittel Bonnie N., GM-CSF Production by Autoreactive T Cells Is Required for the Activation of Microglial Cells and the Onset of Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 178, 1, 2007. Crossref
-
Young Andrew, Linehan Eimear, Hams Emily, O’Hara Hall Aisling C., McClurg Angela, Johnston James A., Hunter Christopher A., Fallon Padraic G., Fitzgerald Denise C., Cutting Edge: Suppression of GM-CSF Expression in Murine and Human T Cells by IL-27, The Journal of Immunology, 189, 5, 2012. Crossref
-
Hamilton John A., GM-CSF in inflammation, Journal of Experimental Medicine, 217, 1, 2020. Crossref
-
Conigliaro Paola, Triggianese Paola, De Martino Erica, Fonti Giulia Lavinia, Chimenti Maria Sole, Sunzini Flavia, Viola Alessandra, Canofari Claudia, Perricone Roberto, Challenges in the treatment of Rheumatoid Arthritis, Autoimmunity Reviews, 18, 7, 2019. Crossref
-
Fleetwood Andrew J., Lawrence Toby, Hamilton John A., Cook Andrew D., Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation, The Journal of Immunology, 178, 8, 2007. Crossref
-
Starosta Vitaliy, Pazdrak Konrad, Boldogh Istvan, Svider Tetyana, Kurosky Alexander, Lipoxin A4Counterregulates GM-CSF Signaling in Eosinophilic Granulocytes, The Journal of Immunology, 181, 12, 2008. Crossref
-
Egea Laia, McAllister Christopher S., Lakhdari Omar, Minev Ivelina, Shenouda Steve, Kagnoff Martin F., GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa, The Journal of Immunology, 190, 4, 2013. Crossref
-
Tekkesin Nilgun, Tetik Sermin, Therapeutic vaccines for pancreatic cancer, in Theranostic Approach for Pancreatic Cancer, 2019. Crossref
-
Li Zhi, Lu Gen, Meng Guangxun, Pathogenic Fungal Infection in the Lung, Frontiers in Immunology, 10, 2019. Crossref
-
Taylor Peter C., Saurigny Didier, Vencovsky Jiri, Takeuchi Tsutomu, Nakamura Tadashi, Matsievskaia Galina, Hunt Barbara, Wagner Thomas, Souberbielle Bernard, Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial, Arthritis Research & Therapy, 21, 1, 2019. Crossref
-
Crotti Chiara, Agape Elena, Becciolini Andrea, Biggioggero Martina, Favalli Ennio Giulio, Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects, Drugs, 79, 16, 2019. Crossref
-
A. Hamilton John, Colony stimulating factors and macrophage heterogeneity, Inflammation and Regeneration, 31, 3, 2011. Crossref
-
Layhadi Janice A., Fountain Samuel J., ATP-Evoked Intracellular Ca2+ Responses in M-CSF Differentiated Human Monocyte-Derived Macrophage are Mediated by P2X4 and P2Y11 Receptor Activation, International Journal of Molecular Sciences, 20, 20, 2019. Crossref
-
El-Behi Mohamed, Ciric Bogoljub, Rostami Abdolmohamad, GM-CSF in Autoimmune Inflammation of the Central Nervous System, in Multiple Sclerosis Immunology, 2013. Crossref
-
Sereno María, Gutiérrez-Gutiérrez Gerardo, Sandoval Carmen, Falagan Sandra, Jimenez-Gordo Ana María, Merino María, López-Menchaca Ramiro, Martínez-Martin Patricia, Roa Silvia, Casado Enrique, A favorable outcome of pneumonia COVID 19 in an advanced lung cancer patient with severe neutropenia: Is immunosuppression a risk factor for SARS-COV2 infection?, Lung Cancer, 145, 2020. Crossref
-
Lee Kevin M.-C., Jarnicki Andrew, Achuthan Adrian, Fleetwood Andrew J., Anderson Gary P., Ellson Christian, Feeney Maria, Modis Louise K., Smith Julia E., Hamilton John A., Cook Andrew, CCL17 in Inflammation and Pain, The Journal of Immunology, 205, 1, 2020. Crossref
-
Chaurasiya Shyambabu, Fong Yuman, Warner Susanne G., Optimizing Oncolytic Viral Design to Enhance Antitumor Efficacy: Progress and Challenges, Cancers, 12, 6, 2020. Crossref
-
Li Xiaofeng, Wang Jiapo, Wu Weimin, Gao Hao, Liu Na, Zhan Guangxi, Li Li, Han Lingfei, Guo Xiaoqing, Myeloid‐derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p‐STAT3 signalling pathway, The FEBS Journal, 287, 23, 2020. Crossref
-
Ifergan Igal, Miller Stephen D., Potential for Targeting Myeloid Cells in Controlling CNS Inflammation, Frontiers in Immunology, 11, 2020. Crossref
-
Shang Lu, Li Jiawei, Song Chunsheng, Nina Zaytseva, Li Qiuke, Chou Shuli, Wang Zhihua, Shan Anshan, Hybrid Antimicrobial Peptide Targeting Staphylococcus aureus and Displaying Anti-infective Activity in a Murine Model, Frontiers in Microbiology, 11, 2020. Crossref
-
Hollen McKenzie K., Efron Philip A., Mohr Alicia M., Is there a role for granulocyte-macrophage colony-stimulating factor and/or erythropoietin in critical illness?, in Evidence-Based Practice of Critical Care, 2020. Crossref
-
Menzel Alain, Samouda Hanen, Dohet Francois, Loap Suva, Ellulu Mohammed S., Bohn Torsten, Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?, Antioxidants, 10, 3, 2021. Crossref
-
Barbeck Mike, Schröder Marie-Luise, Alkildani Said, Jung Ole, Unger Ronald E., Exploring the Biomaterial-Induced Secretome: Physical Bone Substitute Characteristics Influence the Cytokine Expression of Macrophages, International Journal of Molecular Sciences, 22, 9, 2021. Crossref
-
Pykhtina Mariya, Miroshnichenko Svetlana, Romanov Vladimir, Grazhdantseva Antonina, Kochneva Galina, Beklemishev Anatoly, Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity, Pharmaceuticals, 14, 5, 2021. Crossref
-
Clayton Nicholas P., Khan-Malek Richard C., Dangler Charles A., Zhang Donghui, Ascah Alexis, Gains Malcolm, Gardner Brent, Mockbee Colleen, Keutzer Joan M., McManus John, Authier Simon, Sargramostim (rhu GM-CSF) Improves Survival of Non-Human Primates with Severe Bone Marrow Suppression after Acute, High-Dose, Whole-Body Irradiation, Radiation Research, 195, 2, 2020. Crossref
-
Zhu Yong-tong, Pang Shi-yu, Lei Cheng-yong, Luo Yang, Chu Qing-jun, Tan Wan-long, Development of a therapy against metastatic bladder cancer using an interleukin-2 surface-modified MB49 bladder cancer stem cells vaccine, Stem Cell Research & Therapy, 6, 1, 2015. Crossref
-
Wang Huan, Jin Ping, Sabatino Marianna, Ren Jiaqiang, Civini Sara, Bogin Vladimir, Ichim Thomas E, Stroncek David F, Comparison of endometrial regenerative cells and bone marrow stromal cells, Journal of Translational Medicine, 10, 1, 2012. Crossref
-
Li Yankun, Gerbod-Giannone Marie-Christine, Seitz Heather, Cui Dongying, Thorp Edward, Tall Alan R., Matsushima Glenn K., Tabas Ira, Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor, Journal of Biological Chemistry, 281, 10, 2006. Crossref
-
Achuthan Adrian A., Lee Kevin M.C., Hamilton John A., Targeting GM-CSF in inflammatory and autoimmune disorders, Seminars in Immunology, 54, 2021. Crossref
-
Luque‐Martin Rosario, Mander Palwinder K., Leenen Pieter J. M., Winther Menno P. J., Classic and new mediators for in vitro modelling of human macrophages , Journal of Leukocyte Biology, 109, 3, 2021. Crossref
-
Chu Sherman, McCormick Thomas S., Lazarus Hillard M., Leal Luis O., Ghannoum Mahmoud A., Invasive fungal disease and the immunocompromised host including allogeneic hematopoietic cell transplant recipients: Improved understanding and new strategic approach with sargramostim, Clinical Immunology, 228, 2021. Crossref
-
Hammami Ines, Chen Jingkui, Murschel Frederic, Bronte Vincenzo, De Crescenzo Gregory, Jolicoeur Mario, Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models, BMC Cell Biology, 13, 1, 2012. Crossref
-
Lazarus Hillard M., Ragsdale Carolyn E., Gale Robert Peter, Lyman Gary H., Sargramostim (rhu GM-CSF) as Cancer Therapy (Systematic Review) and An Immunomodulator. A Drug Before Its Time?, Frontiers in Immunology, 12, 2021. Crossref
-
Malengier-Devlies Bert, Metzemaekers Mieke, Wouters Carine, Proost Paul, Matthys Patrick, Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis, Frontiers in Immunology, 12, 2021. Crossref
-
Simmons Andrew D., Li Betty, Gonzalez-Edick Melissa, Lin Carol, Moskalenko Marina, Du Thomas, Creson Jennifer, VanRoey Melinda J., Jooss Karin, GM-CSF-secreting cancer immunotherapies: preclinical analysis of the mechanism of action, Cancer Immunology, Immunotherapy, 56, 10, 2007. Crossref
-
Sorrentino Antonio, Ferracin Manuela, Castelli Germana, Biffoni Mauro, Tomaselli Giada, Baiocchi Marta, Fatica Alessandro, Negrini Massimo, Peschle Cesare, Valtieri Mauro, Isolation and characterization of CD146+ multipotent mesenchymal stromal cells, Experimental Hematology, 36, 8, 2008. Crossref
-
Reyes Leticia, Reinhard Mary, O'Donell L. J., Stevens Janet, Brown Mary B., Rat Strains Differ in Susceptibility to Ureaplasma parvum -Induced Urinary Tract Infection and Struvite Stone Formation , Infection and Immunity, 74, 12, 2006. Crossref
-
Engels Eric A., Wu Xifeng, Gu Jian, Dong Qiong, Liu Jun, Spitz Margaret R., Systematic Evaluation of Genetic Variants in the Inflammation Pathway and Risk of Lung Cancer, Cancer Research, 67, 13, 2007. Crossref
-
Jolly Amber Leah, Rau Sameeha, Chadha Anmol K., Abdulraheem Ekhlas Ahmed, Dean Deborah, Nacy Carol A., Stromal Fibroblasts Drive Host Inflammatory Responses That Are Dependent on Chlamydia trachomatis Strain Type and Likely Influence Disease Outcomes, mBio, 10, 2, 2019. Crossref
-
Karagiannidis Ioannis, Salataj Eralda, Said Abu Egal Erika, Beswick Ellen J., G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation, Cytokine, 142, 2021. Crossref
-
Aghaalikhani Nazi, Rashtchizadeh Nadereh, Shadpour Pejman, Allameh Abdolamir, Mahmoodi Marzieh, Cancer stem cells as a therapeutic target in bladder cancer, Journal of Cellular Physiology, 234, 4, 2019. Crossref
-
Moeller Maria, Kershaw Michael H., Cameron Rachel, Westwood Jennifer A., Trapani Joseph A., Smyth Mark J., Darcy Phillip K., Sustained Antigen-Specific Antitumor Recall Response Mediated by Gene-Modified CD4+ T Helper-1 and CD8+ T Cells, Cancer Research, 67, 23, 2007. Crossref
-
Yin Zhi-Qiang, Han Hua, Yan Xianchun, Zheng Qi-Jun, Research Progress on the Pathogenesis of Aortic Dissection, Current Problems in Cardiology, 2022. Crossref
-
Vico Tania, Youssif Catrin, Zare Fathema, Comalada Mònica, Sebastian Carlos, Lloberas Jorge, Celada Antonio, GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation, Cells, 11, 6, 2022. Crossref
-
Zarini Simona, Gijón Miguel A., Folco Giancarlo, Murphy Robert C., Effect of Arachidonic Acid Reacylation on Leukotriene Biosynthesis in Human Neutrophils Stimulated with Granulocyte-macrophage Colony-stimulating Factor and Formyl-methionyl-leucyl-phenylalanine, Journal of Biological Chemistry, 281, 15, 2006. Crossref
-
Nicholson Andrew G., Rice Alexandra J., Interstitial lung diseases, in Spencer's Pathology of the Lung, 2013. Crossref
-
Wang Yi, Han Gencheng, Wang Ke, Liu Guijun, Wang Renxi, Xiao He, Li Xinying, Hou Chunmei, Shen Beifen, Guo Renfeng, Li Yan, Chen Guojiang, Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF, Cancer Research, 74, 3, 2014. Crossref
-
Du T, Shi G, Li Y M, Zhang J F, Tian H W, Wei Y Q, Deng H, Yu D C, Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers, Cancer Gene Therapy, 21, 8, 2014. Crossref
-
Verescakova Hana, Ambrozova Gabriela, Kubala Lukas, Perecko Tomas, Koudelka Adolf, Vasicek Ondrej, Rudolph Tanja K., Klinke Anna, Woodcock Steven R., Freeman Bruce A., Pekarova Michaela, Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages, Free Radical Biology and Medicine, 104, 2017. Crossref
-
McCarthy Cormac, Carey Brenna C., Trapnell Bruce C., Autoimmune Pulmonary Alveolar Proteinosis, American Journal of Respiratory and Critical Care Medicine, 205, 9, 2022. Crossref
-
He Songbing, Wang Liang, Sun Kang, Zhang Yanyun, Li Dechun, Enhanced anti-tumor immunity ex vivo induced by GM-CSF gene transducted dendritic cell vaccine, The Chinese-German Journal of Clinical Oncology, 10, 3, 2011. Crossref
-
Shah Pritha, Siddique Aqsa, Thakkar Ami, Gharat Sankalp, Godad Angel, Kale Pravin, Doshi Gaurav, An update on novel therapeutic intervention in Rheumatoid arthritis, International Immunopharmacology, 109, 2022. Crossref
-
Seo Soo Hong, Han Hee Dong, Noh Kyung Hee, Kim Tae Woo, Son Sang Wook, Chitosan hydrogel containing GMCSF and a cancer drug exerts synergistic anti-tumor effects via the induction of CD8+ T cell-mediated anti-tumor immunity, Clinical & Experimental Metastasis, 26, 3, 2009. Crossref
-
Saita Kosuke, Moriuchi Yuta, Iwagawa Toshiro, Aihara Makoto, Takai Yoshihiro, Uchida Kanji, Watanabe Sumiko, Roles of CSF2 as a modulator of inflammation during retinal degeneration, Cytokine, 158, 2022. Crossref
-
Cheng Lianying, Chen Jie, Rong Xiaofeng, Hu Weicheng, Mechanism of Emodin in the Treatment of Rheumatoid Arthritis, Evidence-Based Complementary and Alternative Medicine, 2022, 2022. Crossref