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Critical Reviews™ in Immunology
インパクトファクター: 1.404 5年インパクトファクター: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v30.i5.10
pages 395-421

Modulation of Intracellular Signaling Using Protein-Transduction Technology

Kouji Kobiyama
Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine; and Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Japan
Nao Jounai
Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Ken J. Ishii
Department of Molecular Protozoology, Research Institute for Microbial Diseases; and Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Toshihiro Horii
Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Koichi Suzuki
Department of Bioregulation, National Institute of Infectious Diseases, Higashimurayama-shi, Japan
Akihide Ryo
Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Fumihiko Takeshita
Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama, Japan

要約

Protein-transduction technology is one of the most promising therapeutic tools for the control of intracellular events. A number of studies have demonstrated that minimal and efficient protein-transduction domains (PTDs) can act as a peptide vector to transfer bioactive cargo molecules from outside to inside the cell. PTD-mediated transduction has the ability to cross the blood-brain barrier, with transduction taking place in most tissues and cell types in vivo. Thus, recombinant proteins fused to or conjugated with PTDs have the potential to be harnessed as supplementary and/or intervention agents directly modulating cell signaling and/or metabolism, or to be applied to vaccine antigens/adjuvants that are efficiently delivered to the optimal site of action to enhance vaccine immunogenicity. This review introduces the mechanism of action, recent applications, and future perspectives of protein-transduction technology as an alternative therapeutic in the post-genome era.


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