年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Heterogeneity of Memory Marginal Zone B Cells
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要約
The marginal zone (MZ) is largely composed of a unique subpopulation of B cells, the so-called MZ-B cells. At a molecular level, memory B cells are characterized by the presence of somatically mutated IGV genes. The earliest studies in the rat have documented the presence of hapten-specific MZ-B cells after immunization in the MZ. This work later received experimental support demonstrating that the IGHV-Cμ transcripts expressed by phenotypically defined splenic MZ-B cells (defined as CD90negIgMhighIgDlow B cells) can carry somatic hypermutation. However, only a minor fraction (< 10%–20%) of these MZ-B cells is mutated and is considered to represent memory B cells. Memory B cells can either be class-switched (IgG, IgA, IgE), or non–class-switched (IgM) B cells. B cells in the MZ are a heterogeneous population of cells and both naïve MZ-B cells; class switched and unswitched memory MZ-B cells are present at this unique site in the spleen. Naïve MZ-B cells carry unmutated Ig genes, produce low-affinity IgM molecules and constitute a first line of defense against invading pathogens. Memory MZ-B cells express high-affinity Ig molecules, directed to (microbial) antigens that have been encountered. In this review, we report on the memory compartment of splenic MZ-B cells in the rat to provide insights into the origin and function of these memory MZ-B cells.
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Hendricks Jacobus, Visser Annie, Dammers Peter M., Burgerhof Johannes G. M., Bos Nicolaas A., Kroese Frans G. M., Sanyal Mrinmoy, The formation of mutated IgM memory B cells in rat splenic marginal zones is an antigen dependent process, PLOS ONE, 14, 9, 2019. Crossref
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Allie S. Rameeza, Randall Troy D., Resident Memory B Cells, Viral Immunology, 33, 4, 2020. Crossref
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Colombo Monica, Bagnara Davide, Reverberi Daniele, Matis Serena, Cardillo Martina, Massara Rosanna, Mastracci Luca, Ravetti Jean Louis, Agnelli Luca, Neri Antonino, Mazzocco Michela, Squillario Margherita, Mazzarello Andrea Nicola, Cutrona Giovanna, Agathangelidis Andreas, Stamatopoulos Kostas, Ferrarini Manlio, Fais Franco, Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach, Molecular Medicine, 26, 1, 2020. Crossref
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Stranavova Lucia, Hruba Petra, Slatinska Janka, Sawitzki Birgit, Reinke Petra, Volk Hans-Dieter, Viklicky Ondrej, Dialysis therapy is associated with peripheral marginal zone B-cell augmentation, Transplant Immunology, 60, 2020. Crossref
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Ochocinski Dominik, Dalal Mansi, Black L. Vandy, Carr Silvana, Lew Judy, Sullivan Kevin, Kissoon Niranjan, Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review, Frontiers in Pediatrics, 8, 2020. Crossref
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Lyashchenko Konstantin P., Vordermeier H. Martin, Waters W. Ray, Memory B cells and tuberculosis, Veterinary Immunology and Immunopathology, 221, 2020. Crossref
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Marinkovic Dragan, Marinkovic Tatjana, Putative role of marginal zone B cells in pathophysiological processes, Scandinavian Journal of Immunology, 92, 3, 2020. Crossref
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Palm Anna-Karin E., Kleinau Sandra, Marginal zone B cells: From housekeeping function to autoimmunity?, Journal of Autoimmunity, 119, 2021. Crossref
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Perez-Chacon Gema, Zapata Juan M., The Traf2DNxBCL2-tg Mouse Model of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Recapitulates the Biased IGHV Gene Usage, Stereotypy, and Antigen-Specific HCDR3 Selection of Its Human Counterpart, Frontiers in Immunology, 12, 2021. Crossref
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Steiniger Birte, Spleen, in eLS, 2021. Crossref
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Doyon-Laliberté Kim, Aranguren Matheus, Poudrier Johanne, Roger Michel, Marginal Zone B-Cell Populations and Their Regulatory Potential in the Context of HIV and Other Chronic Inflammatory Conditions, International Journal of Molecular Sciences, 23, 6, 2022. Crossref
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Hou Yue, Li Yan, Liu Bingqing, Wan Hong, Liu Chang, Xia Wei, Research Progress on B Cells and Thoracic Aortic Aneurysm/Dissection, Annals of Vascular Surgery, 82, 2022. Crossref
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Sedimbi Saikiran K., Hägglöf Thomas, Garimella Manasa G., Wang Shan, Duhlin Amanda, Coelho Ana, Ingelshed Katrine, Mondoc Emma, Malin Stephen G., Holmdahl Rikard, Lane David P., Leadbetter Elizabeth A., Karlsson Mikael C. I., Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses, Proceedings of the National Academy of Sciences, 117, 16, 2020. Crossref
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Schweiger Helmut, Rejtő Judit, Hofbauer Christoph J., Berg Verena, Allacher Peter, Zwiauer Karl, Feistritzer Clemens, Schuster Gerhard, Ay Cihan, Reipert Birgit M., Pabinger Ingrid, Nonneutralizing FVIII-specific antibody signatures in patients with hemophilia A and in healthy donors, Blood Advances, 6, 3, 2022. Crossref
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Kibler Artur, Budeus Bettina, Küppers Ralf, Seifert Marc, The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells, Frontiers in Immunology, 13, 2022. Crossref
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Moon Sangphil, Janssens Ibo, Kim Kyung Hyun, Stijlemans Benoit, Magez Stefan, Radwanska Magdalena, Detrimental Effect of Trypanosoma brucei brucei Infection on Memory B Cells and Host Ability to Recall Protective B-cell Responses, The Journal of Infectious Diseases, 226, 3, 2022. Crossref
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Taylor Joshua A., Hutchinson Mark A., Gearhart Patricia J., Maul Robert W., Antibodies in action: the role of humoral immunity in the fight against atherosclerosis, Immunity & Ageing, 19, 1, 2022. Crossref