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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Interleukin 4–Induced Gene 1 as an Emerging Regulator of B-Cell Biology and its Role in Cutaneous Melanoma

巻 39, 発行 1, 2019, pp. 39-57
DOI: 10.1615/CritRevImmunol.2019030020
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要約

Interleukin 4 (IL4)-induced gene 1 (IL4I1) is an oxidase that degrades l-phenylalanine into phenylpyruvate, hydrogen peroxide, and ammonia. In contrast to other amino acid catabolic enzymes (i.e., indoleamine 2,3-dioxygenase and inducible nitric oxide synthase), IL4I1 is expressed not only in an intracellular form but also an active secreted form. Although about 20 yr ago IL4I1 was identified in murine B cells in response to IL4, we only recently established its key role in controlling B-cell receptor–mediated signaling during murine B-cell ontogeny and responses in physiological settings. Genetic IL4I1 invalidation increases the number of tumor-associated B cells and delays development of spontaneous metastatic melanoma in mice that are transgenic for the RET oncogene, without impairing tumor-specific antibody response. Although no consensus exists on phenotype and functions of melanoma-associated B cells, our results in RET mice argue for a protective role, with IL4I1 dampening this benefit. However, regulation of IL4I1 expression in innate-like and conventional B-cell subsets and its impact on B-cell properties are incompletely known, in particular, in cancer settings. This review aims to summarize our present knowledge of B cells in human and murine melanoma and address emerging questions about the impact of IL4I1 on B-cell functions in physiological and cancer settings. We note that during melanoma progression, IL4I1 may selectively be expressed by regulatory B cells and/or indirectly promote B-cell–mediated immunosuppression.

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  1. Molinier-Frenkel Valérie, Prévost-Blondel Armelle, Castellano Flavia, The IL4I1 Enzyme: A New Player in the Immunosuppressive Tumor Microenvironment, Cells, 8, 7, 2019. Crossref

  2. Conejo-Garcia Jose R., Biswas Subir, Chaurio Ricardo, Humoral immune responses: Unsung heroes of the war on cancer, Seminars in Immunology, 49, 2020. Crossref

  3. Shi Jingwei, Song Xujun, Traub Benno, Luxenhofer Michael, Kornmann Marko, Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer, International Journal of Molecular Sciences, 22, 6, 2021. Crossref

  4. Zhang Xia, Gan Min, Li Jingyun, Li Hui, Su Meicheng, Tan Dongfei, Wang Shaolei, Jia Man, Zhang Liguo, Chen Gang, Endogenous Indole Pyruvate Pathway for Tryptophan Metabolism Mediated by IL4I1, Journal of Agricultural and Food Chemistry, 68, 39, 2020. Crossref

  5. Yang Yu, Long Xuan, Li Guiyun, Yu Xiaohong, Liu Yu, Li Kun, Tian Xiaobin, Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature, Bioengineered, 12, 1, 2021. Crossref

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