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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Genetic Control of DH Reading Frame and Its Effect on B-Cell Development and Antigen-Specifc Antibody Production

巻 30, 発行 4, 2010, pp. 327-344
DOI: 10.1615/CritRevImmunol.v30.i4.20
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要約

The power of the adaptive immune system to identify novel antigens depends on the ability of lymphocytes to create antigen receptors with diverse antigen-binding sites. For immunoglobulins, CDR (complementarity-determining region)-H3 lies at the center of the antigen-binding site, where it often plays a key role in antigen binding. It is created de novo by VDJ rearrangement and is thus the focus for rearrangement-dependent diversity. CDR-H3 is biased for the inclusion of tyrosine. In seeking to identify the mechanisms controlling CDR-H3 amino acid content, we observed that the coding sequence of DH gene segments demonstrate conservation of reading frame (RF)-specific sequence motifs, with RF1 enriched for tyrosine and depleted of hydrophobic and charged amino acids. Use of DH RF1 in functional VDJ transcripts is preferred from the earliest stages of B-cell development, "pushing" CDR-H3 to include specific categories of tyrosine-enriched antigen-binding sites. With development and maturation, the composition of the CDR-H3 repertoire appears to be “pulled” into a more refined specific range. Forcing the use of alternative DH RFs by means of gene targeting alters the expressed repertoire, enriching alternative sequence categories. This change in the repertoire variably affects antibody production and the development of specific B-cell subsets.

によって引用された
  1. Vale Andre M., Kapoor Pratibha, Skibinski Greg A., Elgavish Ada, Mahmoud Tamer I., Zemlin Cosima, Zemlin Michael, Burrows Peter D., Nobrega Alberto, Kearney John F., Briles David E., Schroeder Harry W., The link between antibodies to OxLDL and natural protection against pneumococci depends on DH gene conservation, Journal of Experimental Medicine, 210, 5, 2013. Crossref

  2. Khass Mohamed, Buckley Kevin, Kapoor Pratibha, Schelonka Robert L., Watkins Leticia S., Zhuang Yingxin, Schroeder Harry W., Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c mice, European Journal of Immunology, 43, 3, 2013. Crossref

  3. Trad Ahmad, Tanasa Radu Iulian, Lange Hans, Zemlin Michael, Schroeder Harry W., Lemke Hilmar, Clonal Progression during the T Cell-Dependent B Cell Antibody Response Depends on the Immunoglobulin DH Gene Segment Repertoire, Frontiers in Immunology, 5, 2014. Crossref

  4. Vale Andre M., Kearney John F., Nobrega Alberto, Schroeder Harry W., Development and Function of B Cell Subsets, in Molecular Biology of B Cells, 2015. Crossref

  5. Mroczek Eva Szymanska, Ippolito Gregory C., Rogosch Tobias, Hoi Kam Hon, Hwangpo Tracy A., Brand Marsha G., Zhuang Yingxin, Liu Cun Ren, Schneider David A., Zemlin Michael, Brown Elizabeth E., Georgiou George, Schroeder Harry W., Differences in the Composition of the Human Antibody Repertoire by B Cell Subsets in the Blood, Frontiers in Immunology, 5, 2014. Crossref

  6. Schroeder H.W., Greenspan N.S., Structure and Function of Immunoglobulins, in Reference Module in Biomedical Sciences, 2014. Crossref

  7. Steiniger Sebastian C.J., Dunkle William E., Bammert Gary F., Wilson Thomas L., Krishnan Abhiram, Dunham Steven A., Ippolito Gregory C., Bainbridge Graeme, Fundamental characteristics of the expressed immunoglobulin VH and VL repertoire in different canine breeds in comparison with those of humans and mice, Molecular Immunology, 59, 1, 2014. Crossref

  8. Vale Andre M., Nobrega Alberto, Schroeder Harry W., The role of evolutionarily conserved germ-line DH sequence in B-1 cell development and natural antibody production, Annals of the New York Academy of Sciences, 1362, 1, 2015. Crossref

  9. Cortina-Ceballos Bernardo, Godoy-Lozano Elizabeth Ernestina, Sámano-Sánchez Hugo, Aguilar-Salgado Andrés, Velasco-Herrera Martín Del Castillo, Vargas-Chávez Carlos, Velázquez-Ramírez Daniel, Romero Guillermo, Moreno José, Téllez-Sosa Juan, Martínez-Barnetche Jesús, Reconstructing and mining the B cell repertoire with ImmunediveRsity, mAbs, 7, 3, 2015. Crossref

  10. Duquesnoy R. J., The antibody response to an HLA mismatch: a model for nonself-self discrimination in relation to HLA epitope immunogenicity, International Journal of Immunogenetics, 39, 1, 2012. Crossref

  11. Wang Yuge, Kapoor Pratibha, Parks Robert, Silva-Sanchez Aaron, Alam S. Munir, Verkoczy Laurent, Liao Hua-Xin, Zhuang Yingxin, Burrows Peter, Levinson Michael, Elgavish Ada, Cui Xiangqin, Haynes Barton F., Schroeder Harry, HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence, Immunogenetics, 68, 2, 2016. Crossref

  12. Granato Alessandra, Chen Yuezhou, Wesemann Duane R, Primary immunoglobulin repertoire development: time and space matter, Current Opinion in Immunology, 33, 2015. Crossref

  13. Briney Bryan S., Willis Jordan R., Crowe James E., Hoshino Yoshihiko, Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes, PLoS ONE, 7, 5, 2012. Crossref

  14. Vale Andre M., Cavazzoni Cecília B., Nobrega Alberto, Schroeder Harry W., The Global Self-Reactivity Profile of the Natural Antibody Repertoire Is Largely Independent of Germline DH Sequence, Frontiers in Immunology, 7, 2016. Crossref

  15. Cohn Melvin, Core principles characterizing immune function, European Journal of Immunology, 47, 1, 2017. Crossref

  16. Sutherland Duncan B., Suzuki Keiichiro, Fagarasan Sidonia, Fostering of advanced mutualism with gut microbiota by Immunoglobulin A, Immunological Reviews, 270, 1, 2016. Crossref

  17. Khass Mohamed, Schelonka Robert L., Liu Cun Ren, Elgavish Ada, Morel Laurence, Burrows Peter D., Schroeder Harry W., Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD−iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3, Autoimmunity, 50, 1, 2017. Crossref

  18. Silva-Sanchez Aaron, Liu Cun Ren, Vale Andre M., Khass Mohamed, Kapoor Pratibha, Elgavish Ada, Ivanov Ivaylo I., Ippolito Gregory C., Schelonka Robert L., Schoeb Trenton R., Burrows Peter D., Schroeder Harry W., Boudinot Pierre, Violation of an Evolutionarily Conserved Immunoglobulin Diversity Gene Sequence Preference Promotes Production of dsDNA-Specific IgG Antibodies, PLOS ONE, 10, 2, 2015. Crossref

  19. Cohn M., Somatic diversification of the B cell repertoire requires two cell subsets, Scandinavian Journal of Immunology, 87, 3, 2018. Crossref

  20. Dunn-Walters Deborah, Townsend Catherine, Sinclair Emma, Stewart Alex, Immunoglobulin gene analysis as a tool for investigating human immune responses, Immunological Reviews, 284, 1, 2018. Crossref

  21. Khass Mohamed, Vale Andre M., Burrows Peter D., Schroeder Harry W., The sequences encoded by immunoglobulin diversity (DH) gene segments play key roles in controlling B-cell development, antigen-binding site diversity, and antibody production, Immunological Reviews, 284, 1, 2018. Crossref

  22. Khass Mohamed, Blackburn Tessa, Elgavish Ada, Burrows Peter D., Schroeder Harry W., In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101, Frontiers in Immunology, 9, 2018. Crossref

  23. Hartman Holly, Wang Yuge, Schroeder Harry W., Cui Xiangqin, Gomes Aldrin V., Absorbance summation: A novel approach for analyzing high-throughput ELISA data in the absence of a standard, PLOS ONE, 13, 6, 2018. Crossref

  24. Schrade , Bujotzek , Spick , Wagner , Goerl , Wezler , Georges , Kontermann , Brinkmann , Back-To-Germline (B2G) Procedure for Antibody Devolution, Antibodies, 8, 3, 2019. Crossref

  25. Rogosch Tobias, Kerzel Sebastian, Hoß Katharina, Hoersch Gabriele, Zemlin Cosima, Heckmann Matthias, Berek Claudia, Schroeder Harry W., Maier Rolf F., Zemlin Michael, IgA Response in Preterm Neonates Shows Little Evidence of Antigen-Driven Selection, The Journal of Immunology, 189, 11, 2012. Crossref

  26. Schroeder Harry W., Imboden John B., Torres Raul M., Antigen receptor genes, gene products, and co-receptors, in Clinical Immunology, 2013. Crossref

  27. Rodgers John R., Rich Robert R., Antigens and antigen presentation, in Clinical Immunology, 2013. Crossref

  28. Khass Mohamed, Levinson Michael, Schelonka Robert L., Kapoor Pratibha, Burrows Peter D., Schroeder Harry W., Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig DH Gene Segment, Frontiers in Immunology, 11, 2020. Crossref

  29. Tsuji Naomi, Rothstein Thomas L., Holodick Nichol E., Antigen Receptor Specificity and Cell Location Influence the Diversification and Selection of the B-1a Cell Pool with Age, The Journal of Immunology, 205, 3, 2020. Crossref

  30. Schelonka Robert L., Maheshwari Akhil, The Many Faces of B Cells, NeoReviews, 14, 9, 2013. Crossref

  31. Qiu Qunxiang, Zhang Ping, Zhang Nan, Shen Yan, Lou Shifeng, Deng Jianchuan, Development of a Prognostic Nomogram for Acute Myeloid Leukemia on IGHD Gene Family, International Journal of General Medicine, Volume 14, 2021. Crossref

  32. Gayda Susan, Longenecker Kenton L., Manoj Sharmila, Judge Russell A., Saldana Sylvia C., Ruan Qiaoqiao, Swift Kerry M., Tetin Sergey Y., Water Channel in the Binding Site of a High Affinity Anti-Methotrexate Antibody, Biochemistry, 53, 23, 2014. Crossref

  33. Di Yu, Cai Shuyi, Zheng Shunan, Huang Jinwei, Du Lijuan, Song Yu, Zhang Ming, Wang Zhao, Yu Guotao, Ren Liming, Han Haitang, Zhao Yaofeng, Reshaping the murine immunoglobulin heavy chain repertoire with bovine DH genes, Immunology, 165, 1, 2022. Crossref

  34. Lin Sherry G., Ba Zhaoqing, Du Zhou, Zhang Yu, Hu Jiazhi, Alt Frederick W., Highly sensitive and unbiased approach for elucidating antibody repertoires, Proceedings of the National Academy of Sciences, 113, 28, 2016. Crossref

  35. Khass Mohamed, Blackburn Tessa, Burrows Peter D., Walter Mark R., Capriotti Emidio, Schroeder Harry W., VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites, Science Immunology, 1, 1, 2016. Crossref

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