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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Role of cAMP Phosphodiesterase 4 in Regulation of T-Cell Function

巻 26, 発行 5, 2006, pp. 443-452
DOI: 10.1615/CritRevImmunol.v26.i5.40
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要約

Ligation of both the T-cell receptor (TCR) and the CD28 receptor is required for full T-cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts resulting in raft-associated protein kinase A (PKA) activation and inhibition of proximal T-cell signaling. However, upon TCR and CD28 cross-ligation, β-arrestin in complex with cAMP-specific phosphodiesterase 4 (PDE4) is recruited to lipid rafts, thus downregulating cAMP levels. Consequently, the activities of both PKA and PDE4 seem to be important for the regulation of TCR-induced signaling and T-cell function. We, therefore, propose a novel role for TCR and CD28 co-stimulation in the downmodulation of TCR-induced cAMP-mediated inhibitory signals through the recruitment of β-arrestin and PDE4 to lipid rafts, thus allowing a full T-cell response to occur.

によって引用された
  1. Dou Ai-Xia, Feng Li-Li, Liu Xiao-Qian, Wang Xin, Cyclic adenosine monophosphate involvement in low-dose cyclophosphamide-reversed immune evasion in a mouse lymphoma model, Cellular & Molecular Immunology, 9, 6, 2012. Crossref

  2. Olsen Priscilla C., Coelho Luciana P., da Costa Jorge C.S., Cordeiro Renato S.B., Silva Patricia M.R., Martins Marco A., Two for one: Cyclic AMP mediates the anti-inflammatory and anti-spasmodic properties of the non-anesthetic lidocaine analog JMF2-1, European Journal of Pharmacology, 680, 1-3, 2012. Crossref

  3. Jiang Dianhua, Xie Ting, Liang Jiurong, Noble Paul W., β-Arrestins in the Immune System, in The Molecular Biology of Arrestins, 118, 2013. Crossref

  4. Schafer Peter, Apremilast mechanism of action and application to psoriasis and psoriatic arthritis, Biochemical Pharmacology, 83, 12, 2012. Crossref

  5. Fraser Christopher C., G Protein–Coupled Receptor Connectivity to NF-κB in Inflammation and Cancer, International Reviews of Immunology, 27, 5, 2008. Crossref

  6. Hu Zhide, Huang Yuanlan, Liu Yang, Sun Yi, Zhou Ye, Gu Mingli, Chen Yan, Xia Rong, Chen Sunxiao, Deng Anmei, Zhong Renqian, β-Arrestin 1 Modulates Functions of Autoimmune T Cells from Primary Biliary Cirrhosis Patients, Journal of Clinical Immunology, 31, 3, 2011. Crossref

  7. Matarese Giuseppe, De Rosa Veronica, La Cava Antonio, Regulatory CD4 T cells: sensing the environment, Trends in Immunology, 29, 1, 2008. Crossref

  8. Oberprieler Nikolaus G., Lemeer Simone, Kalland Maria E., Torgersen Knut M., Heck Albert J. R., Taskén Kjetil, High-resolution mapping of prostaglandin E2–dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells, Blood, 116, 13, 2010. Crossref

  9. Wehbi Vanessa L., Taskén Kjetil, Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units, Frontiers in Immunology, 7, 2016. Crossref

  10. Cooney Jeffrey D., Aguiar Ricardo C. T., Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies, Blood, 128, 25, 2016. Crossref

  11. Chimenti Maria Sole, Gramiccia Talia, Saraceno Rosita, Bianchi Luca, Garofalo Virginia, Buonomo Oreste, Perricone Roberto, Chimenti Sergio, Chiricozzi Andrea, Apremilast for the treatment of psoriasis, Expert Opinion on Pharmacotherapy, 16, 13, 2015. Crossref

  12. Carvajal Gonczi Catalina M., Tabatabaei Shafiei Mahdieh, East Ashley, Martire Erika, Maurice-Ventouris Meagane H.I., Darlington Peter J., Reciprocal modulation of helper Th1 and Th17 cells by the β2-adrenergic receptor agonist drug terbutaline, The FEBS Journal, 284, 18, 2017. Crossref

  13. Dugger Kari J., Chrisman Taylor, Sayner Sarah L., Chastain Parker, Watson Kacie, Estes Robert, Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised, BMC Immunology, 19, 1, 2018. Crossref

  14. Korsakova Yu. L., Korotaeva T. V., Apremilast: target synthetic drug for the treatment of psoriatic arthritis and psoriasis, Medical Council, 12, 2018. Crossref

  15. Sharma Manju, Levenson Corey, Browning John C., Becker Emily M., Clements Ian, Castella Paul, Cox Michael E., East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease, Frontiers in Pharmacology, 9, 2018. Crossref

  16. Klein Matthias, Vaeth Martin, Scheel Tobias, Grabbe Stephan, Baumgrass Ria, Berberich-Siebelt Friederike, Bopp Tobias, Schmitt Edgar, Becker Christian, Repression of Cyclic Adenosine Monophosphate Upregulation Disarms and Expands Human Regulatory T Cells, The Journal of Immunology, 188, 3, 2012. Crossref

  17. Ernst Peter B., Garrison James C., Thompson Linda F., Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology, The Journal of Immunology, 185, 4, 2010. Crossref

  18. Tan Ying, Watkins Amanda A., Freeman Benjamin B., Meyers John A., Rifkin Ian R., Lerner Adam, Inhibition of Type 4 Cyclic Nucleotide Phosphodiesterase Blocks Intracellular TLR Signaling in Chronic Lymphocytic Leukemia and Normal Hematopoietic Cells, The Journal of Immunology, 194, 1, 2015. Crossref

  19. Willis Miranda J., Baillie George S., Arrestin-Dependent Localization of Phosphodiesterases, in Arrestins - Pharmacology and Therapeutic Potential, 219, 2014. Crossref

  20. Sasidharan Nair Varun, M Toor Salman, Z Taha Rowaida, Ahmed Ayman A, Kurer Mohamed A, Murshed Khaled, Soofi Madiha E, Ouararhni Khalid, M. Alajez Nehad, Abu Nada Mohamed, Elkord Eyad, Transcriptomic Profiling of Tumor-Infiltrating CD4+TIM-3+ T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients, Vaccines, 8, 1, 2020. Crossref

  21. Sandhu Vijay K., Eder Lihi, Yeung Jensen, Apremilast and its role in psoriatic arthritis, Giornale Italiano di Dermatologia e Venereologia, 155, 4, 2020. Crossref

  22. Epstein Paul M., Basole Chaitali, Brocke Stefan, The Role of PDE8 in T Cell Recruitment and Function in Inflammation, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  23. Torheim Eirik A., Jarnæss Elisabeth, Lygren Birgitte, Taskén Kjetil, Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling, Biochemical Journal, 424, 1, 2009. Crossref

  24. Bakulev A. A., Signaling Рathway Blockers: Action Mechanism, Efficacy, Safety of Therapy for Patients with Psoriasis and Psoriatic Arthritis, Vestnik dermatologii i venerologii, 93, 5, 2017. Crossref

  25. Bakulev A. L., Selective intracellular inhibition of signalling pathways - new direction in systematic treatment of psoriasis patients, Vestnik dermatologii i venerologii, 92, 5, 2016. Crossref

  26. Kelly Kevin, Mejia Alex, Suhasini Avvaru N., Lin An-Ping, Kuhn John, Karnad Anand B., Weitman Steven, Aguiar Ricardo C.T., Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies, Clinical Cancer Research, 23, 5, 2017. Crossref

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