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Journal of Long-Term Effects of Medical Implants

年間 4 号発行

ISSN 印刷: 1050-6934

ISSN オンライン: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

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Blood Flow and Thrombus Formation Determine the Development of Stent Neointima

巻 10, 発行 1&2, 2000, 9 pages
DOI: 10.1615/JLongTermEffMedImplants.v10.i12.70
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要約

To establish a relationship between flow, acute thrombus formation, and late intimal formation in implanted arterial stents, canine femoral arteries with normal blood flow were compared to contralateral femoral arteries with restricted blood flow. Thrombocyte activity over the stent segment was evaluated for 3 h after stent placement with nuclear scanning, following administration of In-111 labeled platelets. To evaluate long-term stent patency in relationship to arterial flow, an additional group of dogs were subjected to long-term observation. Matched, symmetrically implanted femoral stents with normal and restricted flow were explanted at 1, 12, and 24 weeks for histological analysis and comparative measurement of neointimal thickness. Angiographic studies were performed before and after nuclear scan in the acute animals and before explant in the chronic animals. Acutely, heparinization prevented subocclusive or occlusive thrombus, regardless of flow. In the absence of heparinization, normal arterial blood flow did not prevent thrombus formation on stents. Chronically, stents with flow restriction had significantly greater neointimal formation in comparison with unrestricted stents. Histological studies suggested that the stent neointima resulted from progressive replacement of stent thrombus.

によって引用された
  1. Huang Yanming, Liu Xiaoshun, Wang Lan, Li Shengqiao, Verbeken Eric, De Scheerder Ivan, , Coronary Artery Disease, 14, 5, 2003. Crossref

  2. Hanel Ricardo A, Taussky Philipp, Dixon Tanya, Miller David A, Sapin Merlie, Nordeen Jerah D, Tawk Rabih G, Navarro Ramon, Johns Gretchen, Freeman William D, Safety and efficacy of ticagrelor for neuroendovascular procedures. A single center initial experience, Journal of NeuroInterventional Surgery, 6, 4, 2014. Crossref

  3. Henn Christina, Satzl Stefanie, Christoph Patricia, Kurz Patrick, Radeleff Boris, Stampfl Ulrike, Stampfl Sibylle, Berger Irina, Richter Goetz Martin, Efficacy of a Polyphosphazene Nanocoat in Reducing Thrombogenicity, In-stent Stenosis, and Inflammatory Response in Porcine Renal and Iliac Artery Stents, Journal of Vascular and Interventional Radiology, 19, 3, 2008. Crossref

  4. Robaina Samuel, Jayachandran Bhavani, He Yong, Frank Andreas, Moreno Michael R., Schoephoerster Richard T., Moore James E., Platelet Adhesion to Simulated Stented Surfaces, Journal of Endovascular Therapy, 10, 5, 2003. Crossref

  5. Robaina Samuel, Jayachandran Bhavani, He Yong, Frank Andreas, Moreno Michael R., Schoephoerster Richard T., Moore James E., Platelet Adhesion to Simulated Stented Surfaces, Journal of Endovascular Therapy, 10, 5, 2003. Crossref

  6. Huang Yanming, Liu Xiaoshun, Wang Lan, Li Shengqiao, Verbeken Eric, De Scheerder Ivan, Long-term biocompatibility evaluation of a novel polymer-coated stent in a porcine coronary stent model, Coronary Artery Disease, 14, 5, 2003. Crossref

  7. Duraiswamy Nandini, Schoephoerster Richard T., Moreno Michael R., Moore James E., Stented Artery Flow Patterns and Their Effects on the Artery Wall, Annual Review of Fluid Mechanics, 39, 1, 2007. Crossref

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445 記事の閲覧数 15 記事のダウンロード 7 Crossref 引用数 Google
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