年間 4 号発行
ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537
Indexed in
Cardiotoxicity and Apoptotic Activity in Subacute Endosulfan Toxicity and the Protective Effect of Vitamin C in Rabbits: A Pathological Study
要約
Cardiovascular disease is one of the most significant causes of mortality in humans and animals, and its etiology is usually unknown. The aim of this study was to investigate the cardiac pathology of endosulfan toxicity and the protective effect of vitamin C in rabbits. Twenty-four rabbits were divided into 4 groups: (1) the END group was given a daily sublethal dose of endosulfan in corn oil by oral gavage for 6 weeks; (2) the END + C group received the endosulfan as well as vitamin C over the same 6-week period; (3) the OIL + C group received corn oil daily and vitamin C every other day; and (4) the OIL group received only corn oil daily. We observed microscopic hemorrhages, single-cell necrosis, inflammatory reactions, and fibrotic changes in the myocardium in the END group. Small hemorrhages and single-cell necrosis also were seen in some hearts in the END + C group, but no inflammation was observed. Caspase-3 immunoreactivity was more significant in myocardial cells in the END group compared with the others. A protective effect of vitamin C on lesions was observed in the END + C group. These results showed that endosulfan resulted in toxic changes in the hearts of rabbits, but this toxicity could be decreased with vitamin C treatment.
-
Ozmen O, Mor F, Effects of vitamin C on pathology and caspase-3 activity of kidneys with subacute endosulfan toxicity, Biotechnic & Histochemistry, 90, 1, 2015. Crossref
-
Wei Jia-Liu, Zhang Lian-Shuang, Wang Jing-Jing, Guo Fang-Zi, Li Yan-Bo, Zhou Xian-Qing, Sun Zhi-Wei, Endosulfan inducing blood hypercoagulability and endothelial cells apoptosis via the death receptor pathway in Wistar rats, Toxicology Research, 4, 5, 2015. Crossref
-
Wei Jialiu, Zhang Lianshuang, Ren Lihua, Zhang Jin, Yu Yang, Wang Ji, Duan Junchao, Peng Cheng, Sun Zhiwei, Zhou Xianqing, Endosulfan inhibits proliferation through the Notch signaling pathway in human umbilical vein endothelial cells, Environmental Pollution, 221, 2017. Crossref
-
Wei Jialiu, Zhang Lianshuang, Ren Lihua, Zhang Jin, Liu Jianhui, Duan Junchao, Yu Yang, Li Yanbo, Peng Cheng, Zhou Xianqing, Sun Zhiwei, Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways, Science of The Total Environment, 589, 2017. Crossref
-
Shi Lin-Bo, Xu Hua-Ping, Wu Yu-Jie, Li Xin, Gao Jin-Yan, Chen Hong-Bing, The effects of imidacloprid combined with endosulfan on IgE-mediated mouse bone marrow-derived mast cell degranulation and anaphylaxis, Pesticide Biochemistry and Physiology, 148, 2018. Crossref
-
Slade Logan, Cowie Andrew, Martyniuk Chris J., Kienesberger Petra C., Pulinilkunnil Thomas, Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio), Journal of Pharmacology and Experimental Therapeutics, 361, 3, 2017. Crossref
-
Sun ShiTian, Ji ZhengGuo, Fu JiaRong, Wang Xi-Feng, Zhang Lian-Shuang, Endosulfan induces endothelial inflammation and dysfunction via IRE1α/NF-κB signaling pathway, Environmental Science and Pollution Research, 27, 21, 2020. Crossref
-
Wei Jialiu, Liu Jianhui, Zhang Lianshuang, Zhu Yupeng, Li Xiangyang, Zhou Guiqing, Zhao Yanzhi, Sun Zhiwei, Zhou Xianqing, Endosulfan induces cardiotoxicity through apoptosis via unbalance of pro-survival and mitochondrial-mediated apoptotic pathways, Science of The Total Environment, 727, 2020. Crossref
-
Rainey Nathan Earl, Moustapha Aoula, Petit Patrice Xavier, Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref
-
Sathishkumar Palanivel, Mohan Kannan, Ganesan Abirami Ramu, Govarthanan Muthusamy, Yusoff Abdull Rahim Mohd, Gu Feng Long, Persistence, toxicological effect and ecological issues of endosulfan – A review, Journal of Hazardous Materials, 416, 2021. Crossref
-
Li Heng, Liu Shiqi, Hu Yumeng, Zhao Bin, Sun Yeqing, Xu Dan, Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs, Ecotoxicology and Environmental Safety, 192, 2020. Crossref
-
Liu Chao, Ni Chengyu, Liu Weichu, Yang Xiaolian, Zhang Renyi, Zhang Jianling, Luo Man, Xu Jie, Yu Jie, Effects of long-term nonylphenol exposure on myocardial fibrosis and cardiac function in rats, Environmental Sciences Europe, 33, 1, 2021. Crossref
-
El-Nahhal Yasser, El-Nahhal Ibrahim, Cardiotoxicity of some pesticides and their amelioration, Environmental Science and Pollution Research, 28, 33, 2021. Crossref
-
Xu Dan, Liu Tong, Lin Limei, Li Shuai, Hang Xiaoming, Sun Yeqing, Exposure to endosulfan increases endothelial permeability by transcellular and paracellular pathways in relation to cardiovascular diseases, Environmental Pollution, 223, 2017. Crossref
-
Rainey Nathan E., Saric Ana, Leberre Alexandre, Dewailly Etienne, Slomianny Christian, Vial Guillaume, Zeliger Harold I., Petit Patrice X., Synergistic cellular effects including mitochondrial destabilization, autophagy and apoptosis following low-level exposure to a mixture of lipophilic persistent organic pollutants, Scientific Reports, 7, 1, 2017. Crossref