ライブラリ登録: Guest
Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Vernolide-A Inhibits Radiation-Induced Hypoxia-Mediated Tumor Angiogenesis by Regulating HIF-1α, MMP-2, MMP-9, and VEGF

巻 30, 発行 2, 2011, pp. 139-151
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i2.50
Get accessGet access

要約

We investigated the effect of vernolide-A on the inhibition of radiation-induced tumor angiogenesis in C57BL/6 mice. Vernolide-A administration significantly reduced the tumor volume of radiation-exposed mice. Serum vascular endothelial growth factor (VEGF) levels were drastically elevated during tumor progression and irradiation and were significantly reduced by treatment with vernolide-A. Immunohistochemical analysis also revealed reduced vascular density after treatment with vernolide-A, and 3H-thymidine incorporation assay and soft agar assay showed that vernolide-A could inhibit the proliferation of B16F-10 melanoma cells in vitro along with radiation. Vernolide-A also caused a significant inhibition in the invasion of irradiated B16F-10 melanoma cells across the collagen matrix, and inhibited the radiation-induced gene expression of hypoxia-inducible transcription factor-1α (HIF-1α) and VEGF in B16F-10 cells and VEGF receptor (Flk-1) expression in human umbilical vein endothelial cells. Gelatin zymographic analysis showed that vernolide-A could also inhibit the radiation-induced activation of matrix metalloproteinases (MMPs). Our results indicate that vernolide-A inhibits radiation-induced tumor angiogenesis by regulating HIF-1α, MMP-2, MMP-9, and VEGF.

によって引用された
  1. Qin Weiwei, Lu Wenbao, Li Hongwei, Yuan Xiaochen, Li Bingwei, Zhang Qiuju, Xiu Ruijuan, Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation, Journal of Endocrinology, 214, 2, 2012. Crossref

  2. Simonetti O, Lucarini G, Rubini C, Goteri G, Zizzi A, Staibano S, Campanati A, Ganzetti G, Di Primio R, Offidani A, Microvessel density and VEGF, HIF-1α expression in primary oral melanoma: correlation with prognosis, Oral Diseases, 19, 6, 2013. Crossref

  3. Xu Yuan, Zhao Yue, Xu Wenchao, Luo Fei, Wang Bairu, Li Yuan, Pang Ying, Liu Qizhan, Involvement of HIF-2α-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells, Toxicology and Applied Pharmacology, 272, 2, 2013. Crossref

  4. Zbytek Blazej, Peacock Danielle L., Seagroves Tiffany N., Slominski Andrzej, Putative role of HIF transcriptional activity in melanocytes and melanoma biology, Dermato-Endocrinology, 5, 2, 2013. Crossref

  5. Pratheeshkumar Poyil, Son Young-Ok, Divya Sasidharan Padmaja, Roy Ram Vinod, Hitron John Andrew, Wang Lei, Kim Donghern, Dai Jin, Asha Padmaja, Zhang Zhuo, Wang Yitao, Shi Xianglin, Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways, Toxicology and Applied Pharmacology, 281, 2, 2014. Crossref

  6. LIU TING, DU XUELIAN, SHENG XIUGUI, Genetic alterations following ionizing radiation in human ovarian cancer-derived endothelial cells, Molecular Medicine Reports, 9, 6, 2014. Crossref

  7. Lei C., Lin S., Zhang C., Tao W., Dong W., Hao Z., Liu M., Wu B., Activation of cerebral recovery by matrix metalloproteinase-9 after intracerebral hemorrhage, Neuroscience, 230, 2013. Crossref

  8. Alhazzani Khalid, Venkatesan Thiagarajan, Natarajan Umamaheswari, Algahtani Mohammad, Alaseem Ali, Alobid Saad, Rathinavelu Appu, Evaluation of antitumor effects of VEGFR-2 inhibitor F16 in a colorectal xenograft model, Biotechnology Letters, 44, 5-6, 2022. Crossref

Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain