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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Histopathological, Enzymatic, and Molecular Alterations Induced By Cigarette Smoke Inhalation in the Pulmonary Tissue of Mice and Its Amelioration By Aqueous Azadirachta Indica Leaf Extract

巻 31, 発行 1, 2012, pp. 7-15
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.20
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要約

The modulatory and protective effects of aqueous Azadirachta indica leaf extract (AAILE) had been investigated against cigarette smoke−induced pulmonary oxidative stress and risk of lung cancer. Male Balb/c mice were divided in 4 groups: control, cigarette smoke (CS), AAILE, and AAILE + CS. Animals in the CS group were exposed to cigarette smoke for a period of 10 weeks. AAILE oral administration at a dosage of 100 mg/kg body weight was started 2 weeks prior to CS exposure and continued until the termination of the experiment. The pulmonary tissue was analyzed for molecular changes and assessed for the risk of lung cancer and status of pulmonary detoxification enzymes. An increase in CH2/CH3 and decrease in PO2/amide II observed in Fourier transform infrared spectrometry correlated well with acute inflammation, infiltration, and lipid peroxidation levels observed in histopathological studies and malionaldehyde levels in mice exposed to CS. No change was observed in the amide I:amide II ratio. The subtle balance between carcinogen activation and detoxification was found to be derailed, and it was manifested as a 1.5-times increase in the risk of developing lung cancer in the CS-exposed group. However, these changes seemed to normalize upon AAILE supplementation.

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