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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Investigating the Role of Mitochondrial Respiratory Dysfunction during Hexavalent Chromium-Induced Lung Carcinogenesis

巻 37, 発行 4, 2018, pp. 317-329
DOI: 10.1615/JEnvironPatholToxicolOncol.2018028689
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要約

Hexavalent chromium [Cr(VI)] is a lung carcinogen and its complete mechanism of action remains to be investigated. Metabolic reprogramming of key energy metabolism pathways (e.g., increased anaerobic glycolysis in the presence of oxygen or "Warburg effect", dysregulated mitochondrial function, and lipogenesis) are important to cancer cell and tumor survival and growth. In our current understanding of Cr(VI)-induced carcinogenesis, the role for metabolic reprogramming remains unclear. In this study, we treated human lung epithelial cells (BEAS-2B) with Cr(VI) for 6 months and obtained malignantly transformed cells from an isolated colony grown in soft agar. We also used Cr(VI)-transformed cells from two other human lung cell lines (BEP2D and WTHBF-6 cells). Overall, we found that all the Cr(VI)-transformed cells had no changes in their mitochondrial respiratory functions (measured by the Seahorse Analyzer) compared with passaged-matched control cells. Using a xenograft tumor growth model, we generated tumors from these transformed cells in Nude mice. Using cells obtained from the xenograft tumor tissues, we observed that these cells had decreased maximal mitochondrial respiration, spare respiratory capacity, and coupling efficiency. These results provide evidence that, although mitochondrial dysfunction does not occur during Cr(VI)-induced transformation of lung cells, it does occur during tumor development.

によって引用された
  1. Proctor Deborah M., Bhat Virunya, Suh Mina, Reichert Heidi, Jiang Xiaohui, Thompson Chad M., Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches, Regulatory Toxicology and Pharmacology, 124, 2021. Crossref

  2. Ljunggren Stefan A., Ward Liam J., Graff Pål, Persson Anders, Lind Malin Leijon, Karlsson Helen, Akash Muhammad Sajid Hamid, Metal additive manufacturing and possible clinical markers for the monitoring of exposure-related health effects, PLOS ONE, 16, 3, 2021. Crossref

  3. Ventura Célia, Gomes Bruno Costa, Oberemm Axel, Louro Henriqueta, Huuskonen Pasi, Mustieles Vicente, Fernández Mariana F., Ndaw Sophie, Mengelers Marcel, Luijten Mirjam, Gundacker Claudia, Silva Maria João, Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008–2020, Environmental Research, 197, 2021. Crossref

  4. Aendo Paweena, Netvichian Ramnaree, Thiendedsakul Piriyaporn, Khaodhiar Sutha, Tulayakul Phitsanu, Jia Chunrong, Carcinogenic Risk of Pb, Cd, Ni, and Cr and Critical Ecological Risk of Cd and Cu in Soil and Groundwater around the Municipal Solid Waste Open Dump in Central Thailand, Journal of Environmental and Public Health, 2022, 2022. Crossref

  5. Wise John P., Young Jamie L., Cai Jun, Cai Lu, Current understanding of hexavalent chromium [Cr(VI)] neurotoxicity and new perspectives, Environment International, 158, 2022. Crossref

  6. Xue Song, Xu Yiming, Xu Shenglin, Zhong Yiming, Ruan Guangfeng, Ma Jinzhong, Hu Yong, Ding Changhai, Sang Weilin, Mitophagy impairment mediates the pathogenesis of CoCrMo particle-induced osteolysis via NLRP3/caspase-1/GSDMD-dependent pyroptosis in macrophages, Chemical Engineering Journal, 435, 2022. Crossref

  7. Bao Shibo, Zhang Cong, Luo Shengxiang, Jiang Liping, Li Qiujuan, Kong Ying, Cao Jun, HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region, Ecotoxicology and Environmental Safety, 244, 2022. Crossref

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