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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Oleanolic acid induces Apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F

巻 30, 発行 1, 2011, pp. 21-31
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.30
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要約

The objective of this study was to assess the effect of oleanolic acid, a triterpene on inducing apoptosis in B16F-10 melanoma cells. Treatment of B16F-10 cells with nontoxic concentration of oleanolic acid showed the presence of apoptotic bodies and induced DNA fragmentation in a dose depended manner. Cell cycle analysis and TUNEL assay were also confirmed the observation. The apoptotic genes p53, Bax, Caspase-9 and caspase-3 were found upregulated in oleanolic acid treated cells, whereas the anti-apoptotic gene Bcl-2 was downregulated. Oleanolic acid treatment also showed a downregulation of Cyclin D1 expression and upregulated p21 and p27 gene expression in B16F-10 melanoma cells. Oleanolic acid inhibited the activation and nuclear translocation of transcription factors such as NF-κB, c-fos, ATF-2 and CREB-1, and also down regulated the production and expression of TNF-α, IL-1β, IL-6 and GM-CS. These results suggest that oleanolic acid induces apoptosis through activating p53 induced caspase-mediated pro-apoptotic pathway and suppression of NF-κB induced Bcl-2 mediated anti-apoptotic pathway.

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  1. Kim Sung-Min, Jeong Il Ha, Yim Min Su, Chae Min Kyung, Kim Hak Nam, Kim Dong Kue, Kang Choong Mo, Choe Yearn Seong, Lee Chulhyun, Ryu Eun Kyoung, Characterization of oleanolic acid derivative for colon cancer targeting with positron emission tomography, Journal of Drug Targeting, 22, 3, 2014. Crossref

  2. Wei Jianteng, Liu Ming, Liu Haizhou, Wang Hui, Wang Fengxia, Zhang Yuyan, Han Lijun, Lin Xiukun, Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells, Journal of Applied Toxicology, 33, 8, 2013. Crossref

  3. Akl Mohamed R., Elsayed Heba E., Ebrahim Hassan Y., Haggag Eman G., Kamal Amel M., El Sayed Khalid A., 3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells, European Journal of Pharmacology, 740, 2014. Crossref

  4. Liu Jia, Wu Ning, Ma Lei-Na, Zhong Jia-Teng, Liu Ge, Zheng Lan-Hong, Lin Xiu-Kun, p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid, Asian Pacific Journal of Cancer Prevention, 15, 11, 2014. Crossref

  5. Salvador Jorge A.R., Leal Ana S., Alho Daniela P.S., Gonçalves Bruno M.F., Valdeira Ana S., Mendes Vanessa I.S., Jing Yongkui, , 41, 2014. Crossref

  6. Ghosh Samrat, Bishayee Kausik, Khuda-Bukhsh Anisur Rahman, Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: drug-DNA interaction and signaling cascade, Journal of Integrative Medicine, 12, 2, 2014. Crossref

  7. Rui Li Xiao, Shu Song Yu, Jun Wu Jing, Mo Chen Zi, Wu Sun Zheng, Min Liu Shu, Yuan Lin, Yong Peng Jin, Cheng Song Zhi, Sheng Wang Shi, Yao Tang Ze, The dual induction of apoptosis and autophagy by SZC014, a synthetic oleanolic acid derivative, in gastric cancer cells via NF-κB pathway, Tumor Biology, 37, 4, 2016. Crossref

  8. Estko Myriam, Baumgartner Stephan, Urech Konrad, Kunz Matthias, Regueiro Ursula, Heusser Peter, Weissenstein Ulrike, Tumour cell derived effects on monocyte/macrophage polarization and function and modulatory potential of Viscum album lipophilic extract in vitro, BMC Complementary and Alternative Medicine, 15, 1, 2015. Crossref

  9. Wang Zongwei, Dabrosin Charlotta, Yin Xin, Fuster Mark M., Arreola Alexandra, Rathmell W. Kimryn, Generali Daniele, Nagaraju Ganji P., El-Rayes Bassel, Ribatti Domenico, Chen Yi Charlie, Honoki Kanya, Fujii Hiromasa, Georgakilas Alexandros G., Nowsheen Somaira, Amedei Amedeo, Niccolai Elena, Amin Amr, Ashraf S. Salman, Helferich Bill, Yang Xujuan, Guha Gunjan, Bhakta Dipita, Ciriolo Maria Rosa, Aquilano Katia, Chen Sophie, Halicka Dorota, Mohammed Sulma I., Azmi Asfar S., Bilsland Alan, Keith W. Nicol, Jensen Lasse D., Broad targeting of angiogenesis for cancer prevention and therapy, Seminars in Cancer Biology, 35, 2015. Crossref

  10. Sánchez-Quesada Cristina, López-Biedma Alicia, Gaforio José, Oleanolic Acid, a Compound Present in Grapes and Olives, Protects against Genotoxicity in Human Mammary Epithelial Cells, Molecules, 20, 8, 2015. Crossref

  11. Sheikh Bassem Y., Sarker Md. Moklesur Rahman, Kamarudin Muhamad Noor Alfarizal, Ismail Amin, Prophetic medicine as potential functional food elements in the intervention of cancer: A review, Biomedicine & Pharmacotherapy, 95, 2017. Crossref

  12. MA WEI, WANG DI-DI, LI LI, FENG YU-KUAN, GU HONG-MEI, ZHU GUI-MING, PIAO JIN-HUA, YANG YU, GAO XU, ZHANG PENG-XIA, Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells, Oncology Reports, 32, 1, 2014. Crossref

  13. Stammer Rahel Mascha, Kleinsimon Susann, Rolff Jana, Jäger Sebastian, Eggert Angelika, Seifert Georg, Delebinski Catharina I., Synergistic Antitumour Properties ofviscumTTin Alveolar Rhabdomyosarcoma, Journal of Immunology Research, 2017, 2017. Crossref

  14. Ni Zhe, Shang Xifu, Tang Guolin, Niu Lei, Expression of miR-206 in Human Knee Articular Chondrocytes and Effects of miR-206 on Proliferation and Apoptosis of Articular Chondrocytes, The American Journal of the Medical Sciences, 355, 3, 2018. Crossref

  15. Liu Y C, Wang H M, Zeng X H, Research progress of active compounds and pharmacological effects in Akebia trifoliata (Thunb) koidz stems, IOP Conference Series: Earth and Environmental Science, 185, 2018. Crossref

  16. Zhang Qian, Zhou Meiling, Wu Xiangfeng, Li Zhu, Liu Bing, Gao Wenbin, Yue Jin, Liu Tao, Promoting therapeutic angiogenesis of focal cerebral ischemia using thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) in a rat model, Journal of Translational Medicine, 17, 1, 2019. Crossref

  17. Adewole Kayode Ezekiel, Ishola Ahmed Adebayo, Phytosterols and triterpenes from Morinda lucida Benth (Rubiaceae) as potential inhibitors of anti-apoptotic BCL-XL, BCL-2, and MCL-1: an in-silico study, Journal of Receptors and Signal Transduction, 39, 1, 2019. Crossref

  18. Kang Kidong, Quan Khong Trong, Byun Hee Sun, Lee So‐Ra, Piao Xuezhe, Ju Eunjin, Park Kyeong Ah, Sohn Kyung‐Cheol, Shen Han‐Ming, Na MinKyun, Hur Gang Min, 3‐ O ‐acetylrubianol C (3AR‐C) induces RIPK1‐dependent programmed cell death by selective inhibition of IKKβ , The FASEB Journal, 34, 3, 2020. Crossref

  19. Gu Jingyao, Chen Zhenyao, Chen Xin, Wang Zhaoxia, Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer, Clinica Chimica Acta, 507, 2020. Crossref

  20. Ji Xiao-Ling, Liu Xia, Wang Zhe, Fang Ying-Chun, Expression of ARID1A in polycystic ovary syndrome and its effect on the proliferation and apoptosis of ovarian granulosa cells, Annales d'Endocrinologie, 81, 6, 2020. Crossref

  21. Hu Jiamiao, Lin Shaoling, Huang Jim Junhui, Cheung Peter C. K., Mechanistic Study of the In Vitro and In Vivo Inhibitory Effects of Protocatechuic Acid and Syringic Acid on VEGF-Induced Angiogenesis, Journal of Agricultural and Food Chemistry, 66, 26, 2018. Crossref

  22. Mencherini Teresa, Picerno Patrizia, Festa Michela, Russo Paola, Capasso Anna, Aquino Rita, Triterpenoid Constituents from the Roots of Paeonia rockii ssp. rockii, Journal of Natural Products, 74, 10, 2011. Crossref

  23. Aggarwal Vaishali, Kumar Gaurav, Aggarwal Diwakar, Yerer Mükerrem Betül, Cumaoğlu Ahmet, Kumar Manoj, Sak Katrin, Mittal Sonam, Tuli Hardeep Singh, Sethi Gautam, Cancer preventive role of olives and olive oil via modulation of apoptosis and nuclear factor-kappa B activation, in Olives and Olive Oil in Health and Disease Prevention, 2021. Crossref

  24. Liu Haizhou, Schmitz John C., Wei Jianteng, Cao Shousong, Beumer Jan H., Strychor Sandra, Cheng Linyou, Liu Ming, Wang Cuicui, Wu Ning, Zhao Xiangzhong, Zhang Yuyan, Liao Joshua, Chu Edward, Lin Xiukun, Clove Extract Inhibits Tumor Growth and Promotes Cell Cycle Arrest and Apoptosis, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 21, 5, 2014. Crossref

  25. El-Baba Chirine, Baassiri Amro, Kiriako Georges, Dia Batoul, Fadlallah Sukayna, Moodad Sara, Darwiche Nadine, Terpenoids’ anti-cancer effects: focus on autophagy, Apoptosis, 26, 9-10, 2021. Crossref

  26. Sánchez-Quesada Cristina, López-Biedma Alicia, Warleta Fernando, Campos María, Beltrán Gabriel, Gaforio José J., Bioactive Properties of the Main Triterpenes Found in Olives, Virgin Olive Oil, and Leaves of Olea europaea, Journal of Agricultural and Food Chemistry, 61, 50, 2013. Crossref

  27. Li Xianduo, Tang Guanbao, Guo Xuewen, Men Tongyi, Characterization and apoptotic effect of copper nanoparticles biosynthesized from Ziziphus zizyphus leaf on human renal cell carcinoma A498 cells, Applied Nanoscience, 11, 1, 2021. Crossref

  28. Wei Ziheng, Sun Xiaoqi, He Qianqian, Zhao Yang, Wu Yongchao, Han Xue, Wu Zhonglin, Chu Xi, Guan Shengjiang, Nephroprotective effect of magnesium isoglycyrrhizinate against arsenic trioxide‑induced acute kidney damage in mice, Experimental and Therapeutic Medicine, 23, 4, 2022. Crossref

  29. Luo Fangzhen, Wen Yating, Zhao Lanhua, Su Shengmei, Zhao Yuqi, Lei Wenbo, Li Zhongyu, Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria‐mediated host cell apoptosis and chlamydial development , Journal of Cellular and Molecular Medicine, 26, 1, 2022. Crossref

  30. Sharma Monika, Sharma Shweta, Sharma Vikas, Sharma Komal, Yadav Santosh Kumar, Dwivedi Pankaj, Agrawal Satish, Paliwal Sarvesh Kumar, Dwivedi Anil Kumar, Maikhuri Jagdamba Prasad, Gupta Gopal, Mishra Prabhat Ranjan, Rawat Ajay Kumar Singh, Oleanolic–bioenhancer coloaded chitosan modified nanocarriers attenuate breast cancer cells by multimode mechanism and preserve female fertility, International Journal of Biological Macromolecules, 104, 2017. Crossref

  31. Wang Hongzhi, Zhong Weilong, Zhao Jianmin, Zhang Heng, Zhang Qiang, Liang Yuan, Chen Shuang, Liu Huijuan, Zong Shumin, Tian Yixuan, Zhou Honggang, Sun Tao, Liu Yanrong, Yang Cheng, Oleanolic Acid Inhibits Epithelial–Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization, Molecular Cancer Therapeutics, 18, 1, 2019. Crossref

  32. Tezcan Gulcin, Alsaadi Mohammad, Hamza Shaimaa, Garanina Ekaterina E., Martynova Ekaterina V., Ziganshina Gulshat R., Farukshina Elina R., Rizvanov Albert A., Khaiboullina Svetlana F., Azithromycin and Ceftriaxone Differentially Activate NLRP3 in LPS Primed Cancer Cells, International Journal of Molecular Sciences, 23, 16, 2022. Crossref

  33. Mioc Marius, Mioc Alexandra, Prodea Alexandra, Milan Andreea, Balan-Porcarasu Mihaela, Racoviceanu Roxana, Ghiulai Roxana, Iovanescu Gheorghe, Macasoi Ioana, Draghici George, Dehelean Cristina, Soica Codruta, Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents, International Journal of Molecular Sciences, 23, 17, 2022. Crossref

  34. Twilley Danielle, Thipe Velaphi C., Kishore Navneet, Bloebaum Pierce, Roma-Rodrigues Catarina, Baptista Pedro V., Fernandes Alexandra R., Selepe Mamoalosi A., Langhansova Lenka, Katti Kattesh, Lall Namrita, Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis, Pharmaceuticals, 15, 12, 2022. Crossref

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