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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Efficacy of Zinc as a Nutritional Supplement in Ameliorating Chlorpyrifos-Induced Neurotoxicity in Rats

巻 30, 発行 3, 2011, pp. 225-233
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i3.50
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要約

This study aimed to evaluate the efficacy of zinc as a nutritional supplement in preventing chlorpyrifos-induced neurotoxicity in rats. The rats were segregated into 4 groups, which included normal controls and chlorpyrifos-treated, zinc-treated, and chlorpyrifos- and zinc-treated animals. Eight weeks of chlorpyrifos treatment resulted in a significant increase in the levels of lipid peroxidation (LPO) and reactive oxygen species (ROS) in both cerebellum and cerebrum as compared to normal animals. On the contrary, the activities of glutathione-s-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and reduced glutathione (GSH) levels were found to be significantly decreased following chlorpyrifos treatment. Furthermore, chlorpyrifos resulted in anxiety in rats as observed by the elevated plus maze test. In addition, an appreciable decrease was noticed in the muscular as well as locomotor activity of chlorpyrifos-treated animals was noticed by rotarod and actophotometer tests, respectively. However, zinc supplementation to chlorpyrifos-treated animals brought back the already raised levels of LPO and ROS to near normal limits in cerebrum. Moreover, zinc treatment to the chlorpyrifos-treated animals also resulted in a significant improvement in the levels of reduced glutathione, and enzyme activities of GST in both cerebrum as well as cerebellum. Also, improvement was observed in the behavior of chlorpyrifos-treated animals upon zinc supplementation. The present study thus concludes that zinc has potential to act as a neuroprotectant against pesticide-induced neurodegenerative and behavioral disorders but further investigations need to be conducted to understand the exact mechanism of neuroprotection.

キーワード: zinc, chlorpyrifos, neurotoxicity
によって引用された
  1. Uzun Fatma Gokce, Kalender Yusuf, Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin, Food and Chemical Toxicology, 55, 2013. Crossref

  2. Malhotra Anshoo, Dhawan D.K., Current view of zinc as a hepatoprotective agent in conditions of chlorpyrifos induced toxicity, Pesticide Biochemistry and Physiology, 112, 2014. Crossref

  3. Adedara Isaac A., Owoeye Olatunde, Awogbindin Ifeoluwa O., Ajayi Babajide O., Rocha Joao B.T., Farombi Ebenezer O., Diphenyl diselenide abrogates brain oxidative injury and neurobehavioural deficits associated with pesticide chlorpyrifos exposure in rats, Chemico-Biological Interactions, 296, 2018. Crossref

  4. Imam Aminu, Lawal Abideen, Oyewole Lukuman Aboyeji, Ajibola Musa Iyiola, Williams Victoria, Chengetanai Samson, Shittu Toyin Sheu-Tijani, Ajao Moyosore Saliu, Nigella sativa conserved hippocampal oxidative and neurogenic activities to salvage neuro-cognitive integrities in chlorpyrifos insult, Scientific African, 1, 2018. Crossref

  5. Mohamed Wafaa R., Mehany Ahmed B.M., Hussein Rasha M., Alpha lipoic acid protects against chlorpyrifos-induced toxicity in Wistar rats via modulating the apoptotic pathway, Environmental Toxicology and Pharmacology, 59, 2018. Crossref

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