RT Journal Article ID 77cb72336378eb40 A1 Cerveira, Nuno A1 Santos, Joana A1 Teixeira, Manuel R. T1 Structural and Expression Changes of Septins in Myeloid Neoplasia JF Critical Reviews™ in Oncogenesis JO CRO YR 2009 FD 2009-12-01 VO 15 IS 1-2 SP 91 OP 115 K1 septins K1 myeloid neoplasia K1 fusion gene AB Septins are an evolutionarily conserved family of GTP-binding proteins that associate with cellular membranes and the actin and microtubule cytoskeletons. Fourteen septin genes have been characterized to date (SEPT1 to SEPT14) in humans. Septins have been reported to be misregulated in various human diseases, including neurological disorders, infection, and neoplasia. In this review, we describe what is known thus far about septin deregulation in myeloid neoplasia. Septin abnormalities in myeloid neoplasia can be divided into two major groups. First, some septins (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) have been repeatedly identified as in-frame fusion partners of the MLL gene in de novo and therapy-related myeloid neoplasia, in both children and adults. Second, deregulation of the expression of septin family genes in hematological cancers can be observed either with or without the concomitant presence of MLL gene fusions. Although current hypotheses regarding the roles of septins in oncogenesis remain speculative for the most part, the fundamental roles of septins in cytokinesis, membrane remodeling, and compartmentalization can provide some clues on how abnormalities in the septin cytoskeleton could be involved in neo-plastic disorders. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,1aaaaf156ec9f641,77cb72336378eb40.html