RT Journal Article ID 7244cd88076a4b62 A1 Tello, Isaac A1 Campos-Pena, Victoria A1 Montiel-Arcos, Elizur A1 Rodriguez, Veronica A1 Aguirre-Moreno, Alma A1 Leon-Rivera, Ismael A1 del Rio-Portilla, Federico A1 Herrera-Ruiz, Maribel A1 Villeda-Hernandez, Juana T1 Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2013 FD 2013-11-15 VO 15 IS 6 SP 555 OP 568 K1 medicinal mushrooms K1 Lingzhi or Reishi mushroom K1 Ganoderma lucidum K1 oligosaccharide K1 neuroprotective K1 anticonvulsant AB An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)−1-]n (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10−80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,034eeb045436a171,7244cd88076a4b62.html