RT Journal Article
ID 7244cd88076a4b62
A1 Tello, Isaac
A1 Campos-Pena, Victoria
A1 Montiel-Arcos, Elizur
A1 Rodriguez, Veronica
A1 Aguirre-Moreno, Alma
A1 Leon-Rivera, Ismael
A1 del Rio-Portilla, Federico
A1 Herrera-Ruiz, Maribel
A1 Villeda-Hernandez, Juana
T1 Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2013
FD 2013-11-15
VO 15
IS 6
SP 555
OP 568
K1 medicinal mushrooms
K1 Lingzhi or Reishi mushroom
K1 Ganoderma lucidum
K1 oligosaccharide
K1 neuroprotective
K1 anticonvulsant
AB An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)−1-]n (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10−80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,034eeb045436a171,7244cd88076a4b62.html