RT Journal Article
ID 4ebeb064201c87b6
A1 Qian, Keli 
A1 Li, Qian 
A1 Deng, Wanyan
A1 Xiang, Xiaohong 
T1 Multiple-Scales Integrative Analysis of MicroRNAs Unveils Biomarkers and Key Regulatory Connections for Hepatocellular Carcinoma
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2019
FD 2019-06-07
VO 29
IS 3
SP 189
OP 241
K1 hepatocellular carcinoma
K1 microRNAs
K1 biomarkers
K1 multiple-scales integrative analysis
AB Hepatocellular carcinoma is the sixth most common liver cancer worldwide and the third leading cause of cancer mortality. For these reasons, early diagnostic, prognostic, and therapeutic biomarkers are extremely urgent. MicroRNAs are small noncoding single-stranded RNA molecules that are reported to be involved in a variety of physiological and pathological processes during carcinogenesis. In this study, the expression characteristics, functions, and validated targets of microRNAs in HCC were summarized and potential microRNA biomarkers were confirmed from clinical specimens. Multiple-scales integrative analysis was used to predict the diagnostic, prognostic, and therapeutic potential of microRNAs in blood and tissue of HCC patients, providing novel insight into HCC diagnosis and treatment using microRNA biomarkers.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,39c9c23b463492da,4ebeb064201c87b6.html