RT Journal Article ID 3d43d6db6696a8fe A1 Yu, Linghong A1 Wei, Huailing T1 The Hypnotic and Sedative Actions of the Spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) in Mice JF International Journal of Medicinal Mushrooms JO IJM YR 2000 FD 2000-12-01 VO 2 IS 4 OP 6 AB Ganoderma has multiple pharmacological activities and clinical uses. The aqueous extract of G. lucidum (Curt.: Fr.) P. Karst. spores also has many pharmacological activities and clinical uses. The injection made from the spores of G. lucidum (called Jisheng injection) has been used clinically for more than 20 years for its therapeutic effects on several neuromuscular disorders such as myotonia and polymyositis. Jisheng injection can gradually improve a patient's sleep and enhance appetite after he or she takes it for about 2 weeks. To determine the pharmacological bases of the clinical effect of Jisheng injection in improving patients' sleep, the authors investigated the hypnotic and sedative effects of Jisheng injection on the central nervous system in mice. The results are as follows: (1) subcutaneous injection of Jisheng extract significantly prolonged the sleeping time induced by both sodium pentobarbital and barbital in mice in a dose-dependent manner; (2) Jisheng extract also induced sleep in mice after intraperitoneal injection of a subthreshold dose of pentobarbital which could not induce sleep in normal mice; (3) repeated injection of the effectively hypnotic dosage of Jisheng extract once daily for 8 consecutive days did not induce addiction, as the prolonging effect of Jisheng on pentobarbital sleeping time was not shortened, whereas the chemical hypnotic drug diazepam induced addiction after repeated injection for 8 days; and (4) Jisheng injection markedly decreased the spontaneous motor activity in mice. It may be concluded from these results that the aqueous extract of G. lucidum spores has hypnotic and sedative actions on the central nervous system in mice. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,093ad305339fcd09,3d43d6db6696a8fe.html