RT Journal Article ID 2e91decb065f0749 A1 Zhou, Hongyu A1 Huang, Shile T1 mTOR Signaling in Cancer Cell Motility and Tumor Metastasis JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2010 FD 2010-04-30 VO 20 IS 1 SP 1 OP 16 K1 mTOR K1 rapamycin K1 S6K1 K1 Akt K1 cell motility K1 metastasis AB Tumor cell migration is a key step in the formation of cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed serinethreonine kinase, has been intensely studied for over a decade as a central regulator of cell growth, proliferation, differentiation, and survival. Recent data have shown that mTOR also plays a critical role in the regulation of tumor cell motility and cancer metastasis. Here, we briefly review recent advances regarding mTOR signaling in tumor cell motility. We also discuss recent findings about the mechanism by which rapamycin, a specific inhibitor of mTOR, inhibits cell motility in vitro and metastasis in vivo. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,275393334da16faf,2e91decb065f0749.html