RT Journal Article
ID 2e91decb065f0749
A1 Zhou, Hongyu
A1 Huang, Shile
T1 mTOR Signaling in Cancer Cell Motility and Tumor Metastasis
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2010
FD 2010-04-30
VO 20
IS 1
SP 1
OP 16
K1 mTOR
K1 rapamycin
K1 S6K1
K1 Akt
K1 cell motility
K1 metastasis
AB Tumor cell migration is a key step in the formation of cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed serinethreonine kinase, has been intensely studied for over a decade as a central regulator of cell growth, proliferation, differentiation, and survival. Recent data have shown that mTOR also plays a critical role in the regulation of tumor cell motility and cancer metastasis. Here, we briefly review recent advances regarding mTOR signaling in tumor cell motility. We also discuss recent findings about the mechanism by which rapamycin, a specific inhibitor of mTOR, inhibits cell motility in vitro and metastasis in vivo.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,275393334da16faf,2e91decb065f0749.html