RT Journal Article
ID 2c53560e0cbb691f
A1 Socala, Katarzyna
A1 Nieoczym, Dorota
A1 Grzywnowicz, Krzysztof
A1 Stefaniuk, Dawid
A1 Wlaz, Piotr
T1 Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2015
FD 2015-05-06
VO 17
IS 3
SP 209
OP 218
K1 medicinal mushrooms
K1 Ganoderma lucidum
K1 Lingzhi or Reishi mushroom
K1 epilepsy
K1 depression
K1 anxiety
K1 mice
AB Ganoderma lucidum is a well-known medicinal mushroom with a long history of use. This study was designed to assess the anticonvulsant potential of an aqueous extract from cultured G. lucidum mycelium in 3 acute seizure models: timed intravenous pentylenetetrazole infusion, maximal electroshock seizure threshold, and 6-Hz-induced psychomotor seizure tests in mice. Moreover, antidepressant-like and anxiolytic-like effects of G. lucidum were evaluated using the forced swim test and the elevated plus maze test in mice, respectively. No changes in seizure thresholds in the intravenous pentylenetetrazole and maximal electroshock seizure threshold tests after acute treatment with G. lucidum extract (200−600 mg/kg) was observed. However, the studied extract (100−400 mg/kg) significantly increased the threshold for psychomotor seizures in the 6-Hz seizure test. In the forced swim test, G. lucidum (100−400 mg/kg) significantly reduced the duration of immobility. No anxiolytic-like or sedative effects were reported in mice pretreated with the extract (400−600 mg/kg). G. lucidum extract (50−2400 mg/kg) did not produce toxic effects in the chimney test (motor coordination) or grip-strength test (neuromuscular strength). Further studies are required to explain the neuropharmacological effects of G. lucidum and to identify its active ingredients that may affect seizure threshold, mood, or anxiety.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,7b35b5ed6bb0a817,2c53560e0cbb691f.html