RT Journal Article
ID 22866cbd78b4850c
A1 Li, Wei 
A1 Mao, Song
A1 Wu, Liangxia 
A1 Shi, Wenjing 
A1 Zhang, Jianhua 
A1 Wang, Zhong 
T1 Association between the PAI-1 4G/5G Gene Polymorphism and the Risk of Systemic Lupus Erythematosus/Lupus Nephritis
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2019
FD 2019-01-09
VO 29
IS 1
SP 85
OP 94
K1 plasminogen activator inhibitor type 1
K1 polymorphism
K1 systemic lupus erythematosus
K1 lupus nephritis
AB Plasminogen activator inhibitor type 1 (PAI-1) correlates with the risk and progression of systemic lupus erythematosus (SLE). We aimed to assess the relationship between the PAI-1 4G/5G gene polymorphism and SLE/lupus nephritis risk. We identified the eligible studies regarding the association between the PAI-1 4G/5G gene polymorphism and the risk of SLE/lupus nephritis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effects model or, in the presence of heterogeneity, a random-effects model. A total of six studies were enrolled in our pooled analysis. The PAI-1 4G/5G gene polymorphism had no significant association with the risk of SLE among overall populations, Asians and Caucasians. Nor was it associated with susceptibility to lupus nephritis among overall populations, Asians and Caucasians. Sensitivity analysis yielded similar results. No marked publication bias was noted. In conclusion, the PAI-1 4G/5G gene polymorphism is not associated with susceptibility to SLE/lupus nephritis among overall populations, Asians and Caucasians. However, more studies should be conducted in the future.


PB Begell House
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