RT Journal Article ID 1f4cc88f6dc087bd A1 Grant, Sheila A. A1 Bettencourt, Kerry A1 Krulevitch, Peter A1 Hamilton, Julie A1 Glass, Robert T1 Development of Fiber Optic and Electrochemical pH Sensors to Monitor Brain Tissue JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2000 FD 2000-04-01 VO 28 IS 1&2 SP 159 OP 163 AB This article describes fiber optic and electrochemical pH sensors that could become part of a therapeutic arsenal to quickly and aggressively treat stroke victims as well as people who have suffered brain trauma. The fiber optic sensor design was based on the immobilization of a pH-sensitive dye, seminaphthorhodamine-1 carboxylate (SNARF-1C), onto the end of a 125-mm-diameter silica optical fiber using the sol-gel method. A miniature bench-top fluorimeter system was developed for use with the optical fiber to obtain pH measurements. The electrochemical sensor was based on sputter-coated indium oxide thin films. Linear and reproducible responses for both sensors were obtained in human blood with pH varying between 6.8 to 8.0, which encompasses the clinically relevant range. In vivo studies were also performed and results indicated that both types of sensors tracked pH with very little drift. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,63fe0825280eb6c4,1f4cc88f6dc087bd.html