Published 3 issues per year
ISSN Print: 0892-0915
ISSN Online: 2375-0014
Morphinan Neuroprotection: New Insight into the Therapy of Neurodegeneration
ABSTRACT
Neuro-inflammation plays a pivotal role in numerous neurodegenerative disorders, such as Parkinsons disease (PD). Traditional anti-inflammatory drugs have limited therapeutic use because of their narrow spectrum and severe side effects after long-term use. Morphinans are a class of compounds containing the basic morphine structure. The following review will describe novel neuroprotective effects of several morphinans in multiple inflammatory disease models. The potential therapeutic utility and underlying mechanisms of morphinan neuroprotection are discussed.
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Qian Li, Flood Patrick M., Hong Jau-Shyong, Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy, Journal of Neural Transmission, 117, 8, 2010. Crossref
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Flood Patrick M., Qian Li, Peterson Lynda J., Zhang Feng, Shi Jing-Shan, Gao Hui-Ming, Hong Jau-Shyong, Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease, Parkinson's Disease, 2011, 2011. Crossref
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Chen Shiou-Lan, Tao Pao-Luh, Chu Chun-Hsien, Chen Shih-Heng, Wu Hsiang-En, Tseng Leon F., Hong Jau-Shyong, Lu Ru-Band, Low-Dose Memantine Attenuated Morphine Addictive Behavior Through its Anti-Inflammation and Neurotrophic Effects in Rats, Journal of Neuroimmune Pharmacology, 7, 2, 2012. Crossref
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Rafati Ali, Noorafshan Ali, Torabi Nihad, Stereological study of the effects of morphine consumption and abstinence on the number of the neurons and oligodendrocytes in medial prefrontal cortex of rats, Anatomy & Cell Biology, 46, 3, 2013. Crossref
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Elyasi Leila, Eftekhar-Vaghefi Seyed Hassan, Esmaeili-Mahani Saeed, Morphine Protects SH-SY5Y Human Neuroblastoma Cells Against 6-Hydroxydopamine–Induced Cell Damage: Involvement of Anti-Oxidant, Calcium Blocking, and Anti-Apoptotic Properties, Rejuvenation Research, 17, 3, 2014. Crossref
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Yan Zhang , Qiuyue Chen , Yu Long-Chuan, Morphine: A Protective or Destructive Role in Neurons?, The Neuroscientist, 14, 6, 2008. Crossref
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Adedayo Adekomi Damilare, Aderinola Adegoke Adebiyi, Adekilekun Tijani Ahmad, Olaolu Olaniyan Olayinka, Olanike Alabi Mutiyat, Olayemi Ijomone Kafilat, Morphine-alcohol treatment impairs cognitive functions and increases neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats, Anatomy & Cell Biology, 51, 1, 2018. Crossref
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Block Michelle L, NADPH oxidase as a therapeutic target in Alzheimer's disease, BMC Neuroscience, 9, S2, 2008. Crossref
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Qian Li, Tan Kai Soo, Wei Sung-Jen, Wu Hung-Ming, Xu Zongli, Wilson Belinda, Lu Ru-Bin, Hong Jau-Shyong, Flood Patrick M., Microglia-Mediated Neurotoxicity Is Inhibited by Morphine through an Opioid Receptor-Independent Reduction of NADPH Oxidase Activity, The Journal of Immunology, 179, 2, 2007. Crossref