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Critical Reviews™ in Neurobiology

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ISSN Print: 0892-0915

ISSN Online: 2375-0014

SJR: 0.121
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The BDNF Gene: Exemplifying Complexity in Ca2+-Dependent Gene Expression

Volume 16, Issue 1&2, 2004, pp. 43-50
DOI: 10.1615/CritRevNeurobiol.v16.i12.40
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Britt Mellstrom
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
Begona Torres
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
Wolfgang A. Link
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
Jose R. Naranjo
Dpto. Biologia Moleculary Celular, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain

ABSTRACT

Over the last 20 years, great effort has been made to decipher the molecular mechanisms used by cells to transform a cytosolic Ca2+ signal into specific, finely-controlled changes in gene expression. Several previous reviews addressed the variety of regulatory mechanisms that participate in Ca2+-dependent gene expression in neurons (Carafoli et al., 2001; Mellström and Naranjo 2001; West et al., 2001). Nevertheless, recent discoveries have revealed new players and new interactions that tune this process. In this review, we will use the four promoters that regulate the expression of the brain-derived neurotrophic factor (BDNF) gene as a magnificent scenario in which these mechanisms intermingle to show the complexity of Ca2+-dependent gene expression.

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