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Critical Reviews™ in Physical and Rehabilitation Medicine

Published 4 issues per year

ISSN Print: 0896-2960

ISSN Online: 2162-6553

SJR: 0.141 SNIP: 0.129 CiteScore™:: 0.6 H-Index: 18

Indexed in

Clinical Applications of lontophoretic Devices in Rehabilitation Medicine

Volume 10, Issue 2, 1998, pp. 147-179
DOI: 10.1615/CritRevPhysRehabilMed.v10.i2.30
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ABSTRACT

Interest within the healthcare profession in transdermal delivery of pharmaceuticals through passive, mechanical (phonophoresis) or electromotive (iontophoresis) forces has increased significantly throughout the past decade. The current review will examine the histology and cellular biology of the integument system as related to regulation of transcutaneous delivery of pharmaceutics, and examine currently accepted mechanism(s) of iontophoretic delivery. Additionally, a survey of current iontophoretic devices and electrodes available within the U.S. market, and the limitations of current technology will be presented. Experimental research supporting the use of iontophoresis for local delivery of pharmaceuticals will also be presented in conjunction with the outcomes of clinical investigations where iontophoresis was utilized for the local delivery of these pharmaceuticals. Topic areas to be covered within this section include iontophoresis of antibiotics into integument wounds, local anesthetics, and steroidal and nonsteroidal anti-inflammatory drugs. Finally, an examination of the benefits of combining various forces to enhance transcutaneous drug delivery and future direction(s) of research within this field will be discussed. The purpose of the present review is to provide both researchers and clinical practitioners with an objective basis for the current use of iontophoresis in rehabilitation medicine.

CITED BY
  1. BLACKFORD J., DOHERTY T. J., FERSLEW K. E., PANUS P. C., Iontophoresis of dexamethasone-phosphate into the equine tibiotarsal joint, Journal of Veterinary Pharmacology and Therapeutics, 23, 4, 2000. Crossref

  2. Blackford J., Doherty T. J., Ferslew K. E., Panus P. C., Iontophoresis of dexamethasone-phosphate into the equine tibiotarsal joint, Journal of Veterinary Pharmacology and Therapeutics, 23, 4, 2000. Crossref

  3. EASTMAN T., PANUS P. C., HONNAS C. M., FERSLEW K. E., BLACKFORD J., DOHERTY T. J., Cathodic iontophoresis of ketoprofen over the equine middle carpal joint, Equine Veterinary Journal, 33, 6, 2010. Crossref

  4. Blackford J., Doherty T. J., Ferslew K. E., Panus P. C., Iontophoresis of dexamethasone-phosphate into the equine tibiotarsal joint, Journal of Veterinary Pharmacology and Therapeutics, 23, 4, 2000. Crossref

  5. Weber David C., Hoppe Kurtis M., Physical Agent Modalities, in Physical Medicine and Rehabilitation, 2011. Crossref

  6. Paturi Jyotsna, Kim Hyun D., Chakraborty Bireswar, Friden Phillip M., Banga Ajay K., Transdermal and intradermal iontophoretic delivery of dexamethasone sodium phosphate: quantification of the drug localized in skin, Journal of Drug Targeting, 18, 2, 2010. Crossref

  7. Cázares-Delgadillo J., Balaguer-Fernández C., Calatayud-Pascual A., Ganem-Rondero A., Quintanar-Guerrero D., López-Castellano A.C., Merino V., Kalia Y.N., Transdermal iontophoresis of dexamethasone sodium phosphate in vitro and in vivo: Effect of experimental parameters and skin type on drug stability and transport kinetics, European Journal of Pharmaceutics and Biopharmaceutics, 75, 2, 2010. Crossref

  8. Motta Andréa Fontoura, Gomes Borges Noé, Pio da Fonseca José Carlos, Tonussi Carlos Rogério, The antinociceptive effect of iontophoretic direct application of diclofenac to arthritic knee-joints of rats, Life Sciences, 73, 15, 2003. Crossref

  9. Leduc Bernard E, Caya Jocelyne, Tremblay Sylvie, Bureau Nathalie J, Dumont Marc, Treatment of calcifying tendinitis of the shoulder by acetic acid iontophoresis: a double-blind randomized controlled trial11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors(s) or upon any organization with which the author(s) is/are associated., Archives of Physical Medicine and Rehabilitation, 84, 10, 2003. Crossref

  10. Smutok Michael A., Mayo Michele F., Gabaree Catherine L ., Ferslew Kenneth E., Panus Peter C., Failure to Detect Dexamethasone Phosphate in the Local Venous Blood Postcathodic Iontophoresis in Humans, Journal of Orthopaedic & Sports Physical Therapy, 32, 9, 2002. Crossref

  11. Draper David O., Coglianese Mark, Castel Chris, Absorption of Iontophoresis-Driven 2% Lidocaine With Epinephrine in the Tissues at 5 mm Below the Surface of the Skin, Journal of Athletic Training, 46, 3, 2011. Crossref

  12. Coglianese Mark, Draper David O., Shurtz Joseph, Mark Gary, Microdialysis and Delivery of Iontophoresis-Driven Lidocaine Into the Human Gastrocnemius Muscle, Journal of Athletic Training, 46, 3, 2011. Crossref

  13. Anderson Carter R, Morris Russell L, Boeh Stephen D, Panus Peter C, Sembrowich Walter L, Effects of Iontophoresis Current Magnitude and Duration on Dexamethasone Deposition and Localized Drug Retention, Physical Therapy, 83, 2, 2003. Crossref

  14. Panus Peter C, Ferslew Kenneth E, Tober-Meyer Brunhilde, Kao Race L, Ketoprofen Tissue Permeation in Swine Following Cathodic Iontophoresis, Physical Therapy, 79, 1, 1999. Crossref

  15. Diday-Nolle A. P., Behandlungsgrundlagen der Ergotherapie in der Handrehabilitation, in Handrehabilitation, 2009. Crossref

  16. Sylvestre Jean-Philippe, Guy Richard H, Delgado-Charro M Begoña, In Vitro Optimization of Dexamethasone Phosphate Delivery by Iontophoresis, Physical Therapy, 88, 10, 2008. Crossref

  17. Hegazy Fatma A., Aboelnasr Emad A., Salem Yasser T., Effect of lidocaine iontophoresis combined with exercise intervention on gait and spasticity in children with spastic hemiplegic cerebral palsy: A randomized controlled trial, NeuroRehabilitation, 47, 2, 2020. Crossref

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