Library Subscription: Guest
International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Antidiabetic Properties of the Red Belt Conk Medicinal Mushroom Fomitopsis pinicola (Agaricomycetes) Extracts on Streptozotocin-Induced Diabetic Rats

Volume 22, Issue 8, 2020, pp. 731-741
DOI: 10.1615/IntJMedMushrooms.2020035472
Get accessGet access

ABSTRACT

The antidiabetic effect of different doses of water extract (WE) and ethanol extract (EE) was tested on a high-fat diet and streptozotocin (STZ) induced diabetic rats. Parameters were evaluated with normal control (NC), diabetes mellitus control (DM), and metformin (M) groups. In the experiment, nine groups were used with eight rats in each group and three doses of each WE and EE were used, with low, medium, and high doses. The results revealed that the DM group lost a significant amount of weight, whereas the NC group's weight increased throughout the experiment. After treatment with Fomitopsis pinicola, the EE group's weight increased gradually. Liver, kidney, and pancreas weight decreased after STZ injection and returned to normal in EE treated groups. Fasting blood glucose (FBG) levels were observed to be significantly lower after F. pinicola treatment. Serum insulin levels were also restored to normal after mushroom extracts supplementation. Specifically, STZ-induced hyperglycemia was inhibited by high dose EE administration. The biochemical analysis revealed that high-dose EE treatment increased HDL-C and decreased TC, TG, and LDL-C. Results demonstrated that high-dose EE administration protected the organ tissues from oxidative stress by normalizing the antioxidant levels, and CAT, SOD, and GSH-Px suppressed the lethal effect of MDA. The study concluded that F. pinicola EE at the dose 300 mg/kg has a more hypoglycemic, hyperinsulinemic, antioxidant, and antihyperlipidemic effect than NC, DM, and M, and regulates hyperglycemia by increasing insulin secretion.

REFERENCES
  1. Wang J, Wang C, Li S, Li W. Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway. Biomed Pharmacother. 2017;95:1669-77.

  2. Wang HY, Kan WC, Cheng TJ. Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice. Food Chem Toxicol. 2014;69:347-56.

  3. Huang M, Wang F, Zhou X. Hypoglycemic and hypolipidemic properties of polysaccharides from Enterobacter cloacae Z0206 in KKAy mice. Carbohydr Polym. 2015;117:91-8.

  4. Kakkar R, Mantha SV, Radhi J, Prasad K. Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes. Clin Sci. 1998;94(6):623-32.

  5. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008;4(2):89-96.

  6. Chung SS, Ho EC, Lam KS. Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol. 2003;14(Suppl 3):S233-S6.

  7. Lee AY, Chung SS. Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J. 1999;13(1):23-30.

  8. Latha M, Pari L. Modulatory effect of Scoparia dulcis in oxidative stress-induced lipid peroxidation in streptozotocin diabetic rats. J Med Food. 2003;6(4):379-86.

  9. Annida B, Prince PSM. Supplementation of Fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats. J Med Food. 2005;8(3):382-5.

  10. Petrova RD, Wasser SP, Mahajna JA, Denchev CM, Nevo E. Potential role of medicinal mushrooms in breast cancer treatment: Current knowledge and future perspectives. Int J Med Mushrooms. 2005;7(1-2):141-55.

  11. Shnyreva A, Song W, Van Griensven LJLD. Extracts of medicinal mushrooms Agaricus bisporus and Phellinus linteus induce proapoptotic effects in the human leukemia cell line K562. Int J Med Mushrooms. 2010;12(2):167-75.

  12. Tsai SY, Mau JL, Huang SJ. Enhancement of antioxidant properties and increase of content of vitamin D2 and non-volatile components in fresh button mushroom, Agaricus bisporus (higher Basidiomycetes) by y-irradiation. Int J Med Mushrooms. 2014;16(2):137-47.

  13. Wu T, Xu B. Antidiabetic and antioxidant activities of eight medicinal mushroom species from China. Int J Med Mushrooms. 2015;17(2):129-40.

  14. Nyam KL, Chow CF, Tan CS, Ng ST. Antidiabetic properties of the tiger's milk medicinal mushroom, Lignosus rhinocerotis (Agaricomycetes), in streptozotocin-induced diabetic rats. Int J Med Mushrooms. 2017;19(7):607-17.

  15. Zhou S, Liu Y, Yang Y, Tang QJT, Zhang JS. Hypoglycemic activity of polysaccharide from fruiting bodies of the shaggy ink cap medicinal mushroom, Coprinus comatus (higher Basidiomycetes), on mice induced by alloxan and its potential mechanism. Int J Med Mushrooms. 2015;17(10):957-64.

  16. Gaur T, Rao P. Analysis of antibacterial activity and bioactive compounds of the giant mushroom, Macrocybe gigantea (Agaricomycetes), from India. Int J Med Mushrooms. 2017;19(12):1083-92.

  17. Harada E, Morizono T, Saito M. Blood glucose-reducing and fat-reducing effects of a novel medicinal mushroom, Grifola gargal (Agaricomycetes). Int J Med Mushrooms. 2017;19(12):1071-81.

  18. Courvoisier M. Les champignons comestibles dans le monde. Bul Fed Nat Syn Champ. 1999;82:829-37.

  19. Park JP, Kim SW, Hwang H. Optimization of submerged culture conditions for the mycelial growth and exo-biopolymer production by Cordyceps militaris. Lett Appl Microbiol. 2001;33(1):76-81.

  20. Dai YC. Polypore diversity in China with an annotated checklist of Chinese polypores. Mycosci. 2012;53(1):49-80.

  21. Jang KH, Shin KO, Kim SD. Free amino acid and polysaccharide content of submerged mycelial culture of Fomitopsis pinicola. Korean J Food Preserv. 2005;12(4):379-86.

  22. Keller AC, Maillard MP, Hostettmann K. Antimicrobial steroids from the fungus Fomitopsis pinicola. Phytochem. 1996;41(4):1041-6.

  23. Cha WS, Ding JL, Shin HJ, Kim JS, Kim YS, Choi D, Lee CW. Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats. Korean J Chem Eng. 2009;26(6):1696-9.

  24. Yoshikawa K, Inoue M, Matsumoto Y, Sakakibara C, Miyataka H, Matsumoto H, Arihara S. Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2. J Nat Prod. 2005;68(1):69-73.

  25. Rosecke J, Konig WA. Steroids from the fungus Fomitopsis pinicola. Phytochem. 1999;52(8):1621-7.

  26. Usui T, Hosokawa S, Mizuno T, Suzuki T, Meguro H. Investigation of the heterogeneity of heterogalactan from the fruit bodies of Fomitopsis pinicola, by employing concanavalin A-sepharose affinity chromatography. J Biochem. 1981;89(4):1029-37.

  27. Zahid MT, Idrees M, Ying W, Zaki AH, Abdullah I, Haiying B. Review of chemical constituents and pharmacology of brownrot fungus Fomitopsis Pinicola. J Nat Sci Res. 2020;10(2):58-68.

  28. Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol. 2008;118(1):7-13.

  29. Sezik E, Aslan M, Yesilada E, Ito S. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci. 2005;76(11):1223-38.

  30. Zahid MT, Idrees M, Farooq U, Abdullah I, Ying W, Zaki AH, Haiying B. Anti-diabetic, anti-oxidant and anti-hyperlipidemic activity of Fomitopsis pinicola. Int J Biosci. 2020;16(2):102-112.

  31. Chung IM, Kim EH, Yeo MA, Kim SJ, Seo MC, Moon HI. Antidiabetic effects of three Korean sorghum phenolic extracts in normal and streptozotocin-induced diabetic rats. Food Res Int. 2011;44(1):127-32.

  32. Mazzola N. Review of current and emerging therapies in type 2 diabetes mellitus. Am J Manag Care. 2012;18(1): S17-26.

  33. Li JP, Lei Yl, Zhan H. The effects of the king oyster mushroom Pleurotus eryngii (higher Basidiomycetes) on glycemic control in alloxan-induced diabetic mice. Int J Med Mushrooms. 2014;16(3):219-25.

  34. Lo HC, Wasser SP. Medicinal mushrooms for glycemic control in diabetes mellitus: History, current status, future perspectives, and unsolved problems. Int J Med Mushrooms. 2011;13(5):401-26.

  35. Kwon PT, Rahman SS, Kim DM. Maintenance of osseointegration utilizing insulin therapy in a diabetic rat model. J Periodontal. 2005;76(4):621-6.

  36. Golden S, Wals PA, Okajima F, Katz J. Glycogen synthesis by hepatocytes from diabetic rats. Biochem J. 1979;182:727-34.

  37. Li J, Sipple J, Maynard S, Mehta PA, Rose SR, Davies SM, Pang Q. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Antioxid Redox Signal. 2012;17(8):1083-98.

  38. Il'yasova D, Wang F, D'Agostino R. Prospective association between fasting NEFA and type 2 diabetes: Impact of post-load glucose. Diabetologia. 2010;53(5):866-74.

  39. Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest. 2000;106(4):453-8.

  40. Dey A, Lakshmanan J. The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver. Food Funct. 2013;4(8):1148-84.

  41. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36(1):S67-S74.

  42. Miller M. Dyslipidemia and cardiovascular risk: The importance of early prevention. Int J Med. 2009;102(9):657-67.

  43. Xiao C, Wu Q, Xie Y. Hypoglycemic effects of Grifola frondosa (maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats. Food Funct. 2015;6(11):3567-75.

  44. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress: A concise review. Saudi Pharm J. 2016;24(5):547-53.

  45. Zhao H, Li S, Zhang J, Che G. The antihyperlipidemic activities of enzymatic and acidic intracellular polysaccharides by Termitomyces albuminosus. Carbohydr Polym. 2016;151:1227-34.

  46. Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res. 1999;424(1-2):83-95.

CITED BY
  1. Arunachalam Karuppusamy, Sreeja Puthanpura Sasidharan, Yang Xuefei, The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance, Frontiers in Pharmacology, 13, 2022. Crossref

  2. Alzahrani Qushmua, Pinto Luciano, Epistemological Assumption: Understanding Protein Polysaccharide Complexes in Improving Diabetes Treatment, Natural Resources for Human Health, 1, 2, 2021. Crossref

2974 Article views 50 Article downloads Metrics
2974 VIEWS 50 DOWNLOADS 2 Crossref CITATIONS Google
Scholar
CITATIONS

Articles with similar content:

Nephroprotective Effect of Jaggery against Acute and Subchronic Toxicity of Acetaminophen in Wistar Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
Vinay Sharma, Dr. Chandra Kant Sharma
Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 1
S. Vadivukkarasi, P. Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, V. V. Sathibabu Uddandrao, Zhongxi Liu , Saravanan Ganapathy, Zaoni Li
Combined Administration of Monosodium Glutamate and High Sucrose Diet Accelerates the Induction of Type 2 Diabetes, Vascular Dysfunction, and Memory Impairment in Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 1
Anoop Kishore, Kantamaneni Chaitanya, Subhankar Biswas, Jayesh Mudgal, Krishnadas Nandakumar, Pawan G. Nayak, Kaja Saikrishna, Ringu Kumari
Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Santhibhavan Prabhakaran Prabha, Anand Nitha, Puthuparampil Nazarudeen Ansil, Mukalel Sankunni Latha
PPAR-α Agonist Fenofibrate Ameliorates Oxidative Stress in Testicular Tissue of Diabetic Rats Critical Reviews™ in Eukaryotic Gene Expression, Vol.30, 2020, issue 2
Tannaz Jamialahmadi, Habib Yaribeygi, Mohammad Taghi Mohammadi, Amirhossein Sahebkar
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain