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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Acute Toxicity Study and the In Vitro Cytotoxicity of a Black Lingzhi Medicinal Mushroom, Amauroderma rugosum (Agaricomycetes), from Malaysia

Volume 19, Issue 12, 2017, pp. 1093-1099
DOI: 10.1615/IntJMedMushrooms.2017024550
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ABSTRACT

Amauroderma rugosum is a wild medicinal mushroom also known as budak cendawan sawan. Members of the indigenous Malaysian Temuan community wear the fresh stipes as a necklace to prevent epileptic seizure and unremitting crying by babies. In our previous studies, A. rugosum exhibited significant antioxidant and anti-inflammatory activities. The aim of this study was to determine the toxicity (in the event that a stipe is accidentally bitten) and cytotoxicity of this mushroom on Sprague-Dawley rats and selected cell lines. A. rugosum was orally administered to test chemicals according to Organisation for Economic and Co-operation and Development guidelines (TG 425, adopted October 3, 2008). Blood samples were hematologically and biochemically analyzed and multiple tissue sections from each organ were examined using light microscopy. Cytotoxicity of various A. rugosum extracts was also determined against MCF-7 and A-549 cell lines. Our results showed that oral administration of a single dose of mycelial powder (2000 mg/kg) had no adverse effect on the growth rate or hematological and clinical biochemical parameters. Histological studies showed that the treatments did not induce any pathological changes in the organs of the tested animals. All the treated rats survived beyond the 14-day observation period. Methanol and cold and hot water extracts of the freeze-dried mycelial culture of A. rugosum exhibited no or little cytotoxic effect against the MCF-7 and A-549 cell lines.

CITED BY
  1. Wong Jack Ho, Ng Tzi Bun, Chan Helen Hei Ling, Liu Qin, Man Gene Chi Wai, Zhang Chris Zhiyi, Guan Suzhen, Ng Charlene Cheuk Wing, Fang Evandro Fei, Wang Hexiang, Liu Fang, Ye Xiuyun, Rolka Krzysztof, Naude Ryno, Zhao Shuang, Sha Ou, Li Chunman, Xia Lixin, Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials, Applied Microbiology and Biotechnology, 104, 11, 2020. Crossref

  2. Zheng Cheng‐Wen, Cheung Timothy Man‐Yau, Leung George Pak‐Heng, A review of the phytochemical and pharmacological properties of Amauroderma rugosum , The Kaohsiung Journal of Medical Sciences, 38, 6, 2022. Crossref

  3. Mai Yanzhen, Xu Siyuan, Shen Ru, Feng Bairu, He Hong, Xu Yifei, Gastroprotective effects of water extract of domesticated Amauroderma rugosum against several gastric ulcer models in rats, Pharmaceutical Biology, 60, 1, 2022. Crossref

  4. Sun Yi-Fei, Fang Yu-Xuan, Cui Bao-Kai, Taxonomy and phylogeny of Sanguinoderma rugosum complex with descriptions of a new species and a new combination, Frontiers in Microbiology, 13, 2022. Crossref

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