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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effects of Ganoderma lucidum (Higher Basidiomycetes) Extracts on the miRNA Profile and Telomerase Activity of the MCF-7 Breast Cancer Cell Line

Volume 17, Issue 3, 2015, pp. 231-239
DOI: 10.1615/IntJMedMushrooms.v17.i3.30
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ABSTRACT

Ganoderma lucidum is a medicinal higher Basidiomycetes mushroom that exerts anticancer effects through several different mechanisms. This study investigated the effects of G. lucidum on the telomerase activity and microRNA (miRNA) profiles of MCF-7 cells. According to the cytotoxicity results, the G. lucidum ether extract exhibits the highest cytotoxic potency; therefore it was chosen for the subsequent telomerase activity assay and miRNA profiling. The telomerase activity observed in the cells treated with a half-maximal inhibitory concentration of G. lucidum ether extract (100 µg/mL in dimethyl sulfoxide) was 32.2% lower than that of the control cells treated with 1% dimethyl sulfoxide. Among 1066 miRNAs, the most downregulated miRNA was hsa-miR-27a* (4.469-fold), and the most upregulated miRNA was hsa-miR-1285 (10.462-fold). A database search revealed the predicted miRNAs that target the catalytic subunit of the telomerase enzyme telomerase reverse transcriptase, and only miR-3687 (upregulated 2.153-fold) and miR-1207-5p (upregulated 2.895-fold) were changed by at least 2-fold. The miRNA profile changes demonstrated in this study provide a data set regarding their effects on the pathways that regulate telomerase activity in MCF-7 breast cancer cells treated with G. lucidum. These data should aid the development of novel cancer treatment strategies.

CITED BY
  1. Starska Katarzyna, Forma Ewa, Nowacka-Zawisza Maria, Lewy-Trenda Iwona, Ciesielski Piotr, Pietruszewska Wioletta, Skóra Michał, Bryś Magdalena, The c.*229C > T gene polymorphism in 3′UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma, Tumor Biology, 37, 4, 2016. Crossref

  2. Suárez-Arroyo Ivette, Loperena-Alvarez Yaliz, Rosario-Acevedo Raysa, Martínez-Montemayor Michelle, Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer, Medicines, 4, 1, 2017. Crossref

  3. Zhao Gang, Dong Lei, Shi Haitao, Li Hong, Lu Xiaolan, Guo Xiaoyan, Wang Jinhai, MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway, Oncology Reports, 36, 3, 2016. Crossref

  4. Graham Émilie A., Mallet Jean-François, Jambi Majed, Nishioka Hiroshi, Homma Kohei, Matar Chantal, MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC), Cancer Biology & Therapy, 18, 10, 2017. Crossref

  5. Carney Molly C, Tarasiuk Andrij, DiAngelo Susan L, Silveyra Patricia, Podany Abigail, Birch Leann L, Paul Ian M, Kelleher Shannon, Hicks Steven D, Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery, Pediatric Research, 82, 2, 2017. Crossref

  6. Lukong Kiven Erique, Ogunbolude Yetunde, Kamdem Jean Paul, Breast cancer in Africa: prevalence, treatment options, herbal medicines, and socioeconomic determinants, Breast Cancer Research and Treatment, 166, 2, 2017. Crossref

  7. Sohn Eun Jung, Farooqi Ammad Ahmad, Park Hwan Tae, Natural Agents Mediated Regulation of microRNAs: Do We Need Skilled Archers to Hit the Bullseye, in Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs, 2018. Crossref

  8. Hu Yu, Dingerdissen Hayley, Gupta Samir, Kahsay Robel, Shanker Vijay, Wan Quan, Yan Cheng, Mazumder Raja, Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis, Computers in Biology and Medicine, 103, 2018. Crossref

  9. Tsai Jui-Cheng, Liu Wen-Shan, Tseng Ying-Ting, Lam Hoi-Ian, Chen Szu-Ying, Fang Cheng-Li, Tong Tien-Soung, Lai Yun-Ju, Extracts of Cerbera manghas L. effectively inhibit the viability of glioblastoma cell lines and their cancer stemloids in vitro and in mouse xenograft model, Journal of Functional Foods, 48, 2018. Crossref

  10. Aras Aliye, Khalid Sumbul, Jabeen Saima, Farooqi Ammad Ahmad, Xu Baojun, Regulation of cancer cell signaling pathways by mushrooms and their bioactive molecules: Overview of the journey from benchtop to clinical trials, Food and Chemical Toxicology, 119, 2018. Crossref

  11. Sun Yu, Sun Lixin, Cellular and Molecular Mechanism of Ganoderma (Lingzhi) Against Tumor, in Ganoderma and Health, 1182, 2019. Crossref

  12. Mingyi Yang, Belwal Tarun, Devkota Hari Prasad, Li Li, Luo Zisheng, Trends of utilizing mushroom polysaccharides (MPs) as potent nutraceutical components in food and medicine: A comprehensive review, Trends in Food Science & Technology, 92, 2019. Crossref

  13. Wong Jack Ho, Ng Tzi Bun, Chan Helen Hei Ling, Liu Qin, Man Gene Chi Wai, Zhang Chris Zhiyi, Guan Suzhen, Ng Charlene Cheuk Wing, Fang Evandro Fei, Wang Hexiang, Liu Fang, Ye Xiuyun, Rolka Krzysztof, Naude Ryno, Zhao Shuang, Sha Ou, Li Chunman, Xia Lixin, Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials, Applied Microbiology and Biotechnology, 104, 11, 2020. Crossref

  14. Ahmad Md Faruque, Ganoderma lucidum: A rational pharmacological approach to surmount cancer, Journal of Ethnopharmacology, 260, 2020. Crossref

  15. Lucius Khara, Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1, Alternative and Complementary Therapies, 26, 1, 2020. Crossref

  16. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

  17. Kapri Mandira, Srivastav Prem Prakash, Sharma Satyawati, Mushroom as a Source of Fungal Based Functional Foods, in Functional Foods, 2022. Crossref

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