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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.20
7 pages

Antidiabetic Effect of an Acidic Polysaccharide (TAP) from Tremella aurantia Schw.: Fr. (Heterobasidiomycetes) in Genetically Diabetic КК-Аy Mice

Tadashi Kiho
Laboratory of Medical Regulations, Gifu Pharmaceutical University, Japan
Mari Kochi
Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan
Shigeyuki Usui
Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 502-8585, Japan
Kazuyuki Hirano
Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 502-8585, Japan
Koichi Aizawa
Research Institute, Kagome Co., Ltd., 17 Nishitomiyama, Nishinasuno-machi, Nasu-gun, Tochigi 329-2762, Japan
Takahiro Inakuma
Research Institute, Kagome Co., Ltd., 17 Nishitomiyama, Nishinasuno-machi, Nasu-gun, Tochigi 329-2762, Japan

ABSTRACT

Antidiabetic effect of an acidic polysaccharide obtained from the fruiting bodies of Tremella aurantia was studied. Continuous oral administration of а T. aurantia acidic polysaccharide (TAP) solution (0.5 g/L) instead of water to genetically non-insulin-dependent diabetic model (KK-Ay) mice, being already in diabetic condition, were found to depress plasma glucose increases. TAP significantly lowered levels of total-cholesterol, free cholesterol, free fatty acid, and triglyceride in the blood of the mice, and significantly increased high-density lipoprotein (HDL) cholesterol ratio. TAP also significantly lowered the level of free fatty acid in epididymal adipose tissue, while triglyceride content in the tissue was slightly increased. On the other hand, TAP significantly increased glycogen content in hindlimb muscle tissue. The study shows that TAP has an antidiabetic effect, even if the diabetic mice were already at a high plasma glucose level.


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