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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i4.80
pages 377-385

The Effect of Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al., Extract on Methyl Methanesulfonate Caused Genotoxicity in Drosophila melanogaster

Tatjana Savic
Institute of Biological Research, University of Belgrade, Despot Stefan Blvd. 142, 11000 Belgrade, Serbia
Aleksandra Patenkovic
Institute of Biological Research, University of Belgrade, Despot Stefan Blvd. 142, 11000 Belgrade, Serbia
Marina Sokovic
Department of Plant Physiology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia
Jasmina Glamoclija
Institute of Biological Research, University of Belgrade, Despot Stefan Blvd. 142, 11000 Belgrade, Serbia
Marko Andjelkovic
Institute of Biological Research, University of Belgrade, Despot Stefan Blvd. 142, 11000 Belgrade; Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia
Leonardus Johannes Lambertus Donatus Van Griensven
Plant Research International, Wageningen University and Research Centre, Wageningen, the Netherlands

ABSTRACT

The effect of culinary-medicinal Royal Sun Agaricus (Agaricus brasiliensis) hot water extract on methyl methane sulfonate (MMS) induced mutagenicity/genotoxity in Drosophila melanogaster was studied using a quick and broadly applicable in vivo assay, i.e., the wing somatic mutation and recombination test. We used 2nd instar larvae, trans-heterozygous for the third chromosome recessive markers, i.e., multiple wing hairs (mvh) and flare-3 [flr (3)], and fed them for 24 h with the aqueous extract of A. brasiliensis. For antigenotoxicity studies a 24-h pretreatment with the extract was done, followed by a 48-h treatment of the then 3rd instar larvae with MMS. The frequency of mutations of the wing blade changes (i.e., of the number of wing spots of different sizes) induced in somatic cells was determined as a parameter of genetic changes of the wing imaginal discs. The results showed that A. brasiliensis extract did not cause any genotoxic or mutagenic effects. No antigenotoxic and/or protective effect against the induction of mutations by MMS was observed. Instead, a possible enhanced mitotic recombination frequency by MMS was seen after pretreatment of the larvae with A. brasiliensis extract. Possible mechanisms of action are discussed.


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