Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
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In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells
ABSTRACT
The aim of this study was to evaluate whether the cold-water extracts of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), 2 of the most prized wild and cultivated edible mushrooms, can affect the tumor phenotype of human colon cancer HCT116 cells. Our results showed that treatment with CWE-Pef and CWE-Pn resulted in a significant inhibition of the viability of HCT116 cells and promoted apoptosis, as also demonstrated by the increase of Bax-to-Bcl-2 messenger RNA ratio. Moreover, we observed that both extracts were able to inhibit cell migration and to affect homotypic and heterotypic cell-cell adhesion. It also was found that treatment with CWE-Pef and CWE-Pn negatively modulated the phosphorylation of the protein tyrosine as well as the phosphorylation levels of extracellular signal-regulated kinase 1/2. In conclusion, the in vitro antitumor effects of CWE-Pef and CWE-Pn indicate that they can be considered as possible sources for new alternative therapeutic agents for cancer treatment.
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Venturella Giuseppe, Gargano Maria Letizia, Medicinal Properties of Mediterranean Oyster Mushrooms: Species of Genus Pleurotus (Higher Basidiomycetes), in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref
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Venturella Giuseppe, Saporita Paola, Gargano Maria Letizia, Current Research on Medicinal Mushrooms in Italy, in Medicinal Mushrooms, 2019. Crossref
-
Younis Ahmed M., Yosri Mohamed, Stewart Jennifer K., In vitro evaluation of pleiotropic properties of wild mushroom Laetiporus sulphureus, Annals of Agricultural Sciences, 64, 1, 2019. Crossref
-
Venturella Giuseppe, Ferraro Valeria, Cirlincione Fortunato, Gargano Maria Letizia, Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials, International Journal of Molecular Sciences, 22, 2, 2021. Crossref
-
Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref
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Chandrawanshi Nagendra Kumar, Koreti Deepali, Kosre Anjali, Mahish Pramod Kumar, Mushroom-Derived Bioactive-Based Nanoemulsion, in Handbook of Research on Nanoemulsion Applications in Agriculture, Food, Health, and Biomedical Sciences, 2022. Crossref
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Cateni Francesca, Gargano Maria Letizia, Procida Giuseppe, Venturella Giuseppe, Cirlincione Fortunato, Ferraro Valeria, Mycochemicals in wild and cultivated mushrooms: nutrition and health, Phytochemistry Reviews, 21, 2, 2022. Crossref
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Cirlincione Fortunato, Gargano Maria Letizia, Venturella Giuseppe, Mirabile Giulia, Conservation Strategies of the Culinary-Medicinal Mushroom Pleurotus nebrodensis (Basidiomycota, Fungi), The 2nd International Electronic Conference on Diversity (IECD 2022)—New Insights into the Biodiversity of Plants, Animals and Microbes, 2022. Crossref
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Bisko Nina, Lomberg Margarita, Mykchaylova Oksana, Mytropolska Nadiya, Kutovenko Vira, Gryganskyi Andrii, Biology, morphology, and phylogeny of some strains of the Pleurotus eryngii species complex, Archives of Biological Sciences, 74, 3, 2022. Crossref