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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells

Volume 16, Issue 1, 2014, pp. 49-63
DOI: 10.1615/IntJMedMushr.v16.i1.50
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ABSTRACT

The aim of this study was to evaluate whether the cold-water extracts of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), 2 of the most prized wild and cultivated edible mushrooms, can affect the tumor phenotype of human colon cancer HCT116 cells. Our results showed that treatment with CWE-Pef and CWE-Pn resulted in a significant inhibition of the viability of HCT116 cells and promoted apoptosis, as also demonstrated by the increase of Bax-to-Bcl-2 messenger RNA ratio. Moreover, we observed that both extracts were able to inhibit cell migration and to affect homotypic and heterotypic cell-cell adhesion. It also was found that treatment with CWE-Pef and CWE-Pn negatively modulated the phosphorylation of the protein tyrosine as well as the phosphorylation levels of extracellular signal-regulated kinase 1/2. In conclusion, the in vitro antitumor effects of CWE-Pef and CWE-Pn indicate that they can be considered as possible sources for new alternative therapeutic agents for cancer treatment.

CITED BY
  1. Venturella Giuseppe, Gargano Maria Letizia, Medicinal Properties of Mediterranean Oyster Mushrooms: Species of Genus Pleurotus (Higher Basidiomycetes), in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref

  2. Venturella Giuseppe, Saporita Paola, Gargano Maria Letizia, Current Research on Medicinal Mushrooms in Italy, in Medicinal Mushrooms, 2019. Crossref

  3. Younis Ahmed M., Yosri Mohamed, Stewart Jennifer K., In vitro evaluation of pleiotropic properties of wild mushroom Laetiporus sulphureus, Annals of Agricultural Sciences, 64, 1, 2019. Crossref

  4. Venturella Giuseppe, Ferraro Valeria, Cirlincione Fortunato, Gargano Maria Letizia, Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials, International Journal of Molecular Sciences, 22, 2, 2021. Crossref

  5. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

  6. Chandrawanshi Nagendra Kumar, Koreti Deepali, Kosre Anjali, Mahish Pramod Kumar, Mushroom-Derived Bioactive-Based Nanoemulsion, in Handbook of Research on Nanoemulsion Applications in Agriculture, Food, Health, and Biomedical Sciences, 2022. Crossref

  7. Cateni Francesca, Gargano Maria Letizia, Procida Giuseppe, Venturella Giuseppe, Cirlincione Fortunato, Ferraro Valeria, Mycochemicals in wild and cultivated mushrooms: nutrition and health, Phytochemistry Reviews, 21, 2, 2022. Crossref

  8. Cirlincione Fortunato, Gargano Maria Letizia, Venturella Giuseppe, Mirabile Giulia, Conservation Strategies of the Culinary-Medicinal Mushroom Pleurotus nebrodensis (Basidiomycota, Fungi), The 2nd International Electronic Conference on Diversity (IECD 2022)—New Insights into the Biodiversity of Plants, Animals and Microbes, 2022. Crossref

  9. Bisko Nina, Lomberg Margarita, Mykchaylova Oksana, Mytropolska Nadiya, Kutovenko Vira, Gryganskyi Andrii, Biology, morphology, and phylogeny of some strains of the Pleurotus eryngii species complex, Archives of Biological Sciences, 74, 3, 2022. Crossref

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