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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v1.i4.20
pages 301-316

Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)

Takashi Mizuno
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan
Cun Zhuang
Mushroom Wisdom Inc., 1 Madison Street, Building F, East Rutherford, NJ 07073, USA
Kuniaki Abe
Kyowa Engineering Co. Ltd., 1-8-5 Shinkawa, Chuo-ku, Tokyo, 104, Japan
Hidehumi Okamoto
Chihaya Co. Ltd., 10-10 Tenjinmae, Takamatsu, 760, Japan
Tadashi Kiho
Laboratory of Medical Regulations, Gifu Pharmaceutical University, Japan
Shigeo Ukai
Gifu Pharmaceutical University, 5-6-1, Gifu, 502, Japan
Sophie Leclerc
C.N.R.S., Station Biologique, Place G. Teissier, B.P 74, 29682 Roscoff cedex, France
Laurent Meijer
C.N.R.S., Station Biologique, Place G. Teissier, B.P 74, 29682 Roscoff cedex, France


Protein-containing polysaccharides from Inonotus obliquus (Chaga), sclerotia and mycelia were extracted and partially purified. They were examined as potential inhibitors of the cell cycle regulatory enzymes cdc25 and cdc2/cyclin B and for their hypoglycemic effect, and the following results were obtained. The enzyme inhibitory activity and the hypoglycemic effects in normal mice were detected in both water-soluble and water-insoluble polysaccharides. The active principles were β-glucan, heteroglucan, and their protein complexes. No clear antienzymic traits were recognized by polysaccharides prepared from mycelia, but the hypoglycemic effect maintained for 3−48 h by the injection was recognized.