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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v1.i4.50
pages 331-336

The Action of Higher Basidiomycetes Mushrooms Mycelia on Plasma Lipids and Lipoproteins of Hyperlipidemic Rats and Guinea Pigs

Olga V. Remesova
Department of Biochemistry, Institute of Experimental Medicine, Russian Academy of Medical Sciences, 12 Ac. Pavlov Str., Saint Petersburg 197376, Russia
Nina P. Denisova
V. L. Komarov Botanical Institute Russian Academy of Sciences Prof. Popova Str. 2 St. Petersburg 197376, Russia

ABSTRACT

Experiments in rats and guinea pigs have shown that mycelia of two mushrooms, Flammulina velutipes (Curt.: Fr.) P.Karst., and Coprinus domesticus (Bolt.: Fr.) S.F. Gray, reduced contents of total cholesterol in the blood serum and liver under conditions of induced hyperlipidemia. High levels of triglycerides in guinea pigs were decreased by administering the studied mycelia. The cholesterol index of atherogenicity and liver index declined significantly. Moreover, it was documented that the mycelia of the two mushrooms improved lipoprotein metabolism by decreasing the content of low-density lipoproteins and increasing the content of high-density lipoproteins. The data support recommendations to use F. velutipes and C. domesticus mycelia for prevention and treatment of atherosclerosis.