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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Stimulation of Human Innate Immune Cells by Medicinal Mushroom Sclerotial Polysaccharides

Volume 11, Issue 3, 2009, pp. 215-223
DOI: 10.1615/IntJMedMushr.v11.i3.10
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ABSTRACT

Polysaccharides extracted from the sclerotia of medicinal mushrooms Pleurotus tuberregium (PT) and Polyporus rhinocerus (PR), including two water-soluble polysaccharide-protein complexes (PTW and PRW) and a β-glucan (PRG), were incubated with human innate immune cells, and the extracellular cytokines released by the immune cells to the culture medium were analyzed by using the RayBio® human cytokine antibody array. PRG significantly stimulated the proliferation of NK-92MI cells with a corresponding increase in the expression of cytokines IL-2 and I-309, which belong to the chemokine subfamily and are known to be chemotactic for monocytes. All three sclerotial polysaccharides stimulated the proliferation of CD56+ natural killer (NK) and human normal spleen monocytes/macrophages (MD) cells. Cell surface β-glucan receptors on the immune cells treated with the sclerotial polysaccharides were stained with antibodies of dectin-1 and its isotypes before flow cytometric analysis. Dectin-1 expression on NK-92MI and MD cells, but not on CD56+ NK cells, was upregulated by the three sclerotial polysaccharides. The above results suggest the stimulatory effect of mushroom sclerotial polysaccharides on human innate immune cells. These results provide some insight into the mechanism of immunomodulation of mushroom polysaccharides and their potential development into antitumor agents.

CITED BY
  1. Lee Sook Shien, Tan Nget Hong, Fung Shin Yee, Pailoor Jayalakshmi, Sim Si Mui, Evaluation of the sub-acute toxicity of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom, Journal of Ethnopharmacology, 138, 1, 2011. Crossref

  2. Lee M. L., Tan N. H., Fung S. Y., Tan C. S., Ng S. T., The Antiproliferative Activity of Sclerotia ofLignosus rhinocerus(Tiger Milk Mushroom), Evidence-Based Complementary and Alternative Medicine, 2012, 2012. Crossref

  3. Lee Sook Shien, Enchang Francis Kanyan, Tan Nget Hong, Fung Shin Yee, Pailoor Jayalakshmi, Preclinical toxicological evaluations of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom, Journal of Ethnopharmacology, 147, 1, 2013. Crossref

  4. Chen Tai-I, Zhuang Hui-Wen, Chiao Yu-Chung, Chen Chin-Chu, Mutagenicity and genotoxicity effects of Lignosus rhinocerotis mushroom mycelium, Journal of Ethnopharmacology, 149, 1, 2013. Crossref

  5. Kong Boon-Hong, Tan Nget-Hong, Fung Shin-Yee, Pailoor Jayalakshmi, Tan Chon-Seng, Ng Szu-Ting, Nutritional composition, antioxidant properties, and toxicology evaluation of the sclerotium of Tiger Milk Mushroom Lignosus tigris cultivar E, Nutrition Research, 36, 2, 2016. Crossref

  6. Seow Syntyche Ling-Sing, Eik Lee-Fang, Naidu Murali, David Pamela, Wong Kah-Hui, Sabaratnam Vikineswary, Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells, Scientific Reports, 5, 1, 2015. Crossref

  7. Yap Hui-Yeng Y., Chooi Yit-Heng, Fung Shin-Yee, Ng Szu-Ting, Tan Chon-Seng, Tan Nget-Hong, Subudhi Prasanta K., Transcriptome Analysis Revealed Highly Expressed Genes Encoding Secondary Metabolite Pathways and Small Cysteine-Rich Proteins in the Sclerotium of Lignosus rhinocerotis, PLOS ONE, 10, 11, 2015. Crossref

  8. Lau Beng Fye, Abdullah Noorlidah, Sclerotium-Forming Mushrooms as an Emerging Source of Medicinals, in Mushroom Biotechnology, 2016. Crossref

  9. Hu Ting, Huang Qilin, Wong Kahing, Yang Hong, Structure, molecular conformation, and immunomodulatory activity of four polysaccharide fractions from Lignosus rhinocerotis sclerotia, International Journal of Biological Macromolecules, 94, 2017. Crossref

  10. Lee Sook-Shien, Tan Nget-Hong, Pailoor Jayalakshmi, Fung Shin-Yee, Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies, Frontiers in Pharmacology, 8, 2017. Crossref

  11. Fung Shin-Yee, Tan Chon-Seng, The Bioactivity of Tiger Milk Mushroom: Malaysia’s Prized Medicinal Mushroom, in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref

  12. Hu Ting, Huang Qilin, Wong Kahing, Yang Hong, Gan Jingsi, Li Yanru, A hyperbranched β-d-glucan with compact coil conformation from Lignosus rhinocerotis sclerotia, Food Chemistry, 225, 2017. Crossref

  13. Jhou Bo-Yi, Liu Hsiao-Hui, Yeh Shu-Hsing, Chen Chin-Chu, Oral reproductive and developmental toxicity of Lignosus rhinocerotis mycelium in rat, Journal of Ethnopharmacology, 208, 2017. Crossref

  14. Wu Fang, Zhou Li-Wei, Yang Zhu-Liang, Bau Tolgor, Li Tai-Hui, Dai Yu-Cheng, Resource diversity of Chinese macrofungi: edible, medicinal and poisonous species, Fungal Diversity, 98, 1, 2019. Crossref

  15. Lemieszek Marta K., Nunes Fernando M., Rzeski Wojciech, Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon, Food & Function, 10, 9, 2019. Crossref

  16. Fung Shin-Yee, Tan Chon-Seng, Tiger Milk Mushroom (The Lignosus Trinity) in Malaysia: A Medicinal Treasure Trove, in Medicinal Mushrooms, 2019. Crossref

  17. 林 靖倚, Evaluation of Effectiveness of Liquid Fermented Lignosus rhinocerus Mycelium against H1N1 Influenza Virus Infections, Hans Journal of Food and Nutrition Science, 09, 02, 2020. Crossref

  18. Hu Ting, Cai Wudan, Cai Wenfei, Zheng Zhaomin, Xiao Yidong, Huang Qilin, Structure, size and aggregated morphology of a β-D-glucan from Lignosus rhinocerotis as affected by ultrasound, Carbohydrate Polymers, 269, 2021. Crossref

  19. Lau Beng Fye, Abdullah Noorlidah, Aminudin Norhaniza, Lee Hong Boon, Tan Pei Jean, Ethnomedicinal uses, pharmacological activities, and cultivation of Lignosus spp. (tiger׳s milk mushrooms) in Malaysia – A review, Journal of Ethnopharmacology, 169, 2015. Crossref

  20. Wu Bingmin, Wang Yange, Zeng Lishan, Li Wengkun, An Lin, Li Jingyan, Zhan Ruoting, Kang Huasheng, Liu Li, Lin Ying, Zhang Guifang, Ahmad Aqeel, Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild Lignosus rhinocerotis, BioMed Research International, 2022, 2022. Crossref

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