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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i3.30
pages 237-248

Macrophage Stimulation by Polysaccharides Isolated from Barometer Earthstar Mushroom, Astraeus hygrometricus (Pers.) Morgan (Gasteromycetideae)

Sanjaya Kumar Mallick
Department of Biotechnology, Indian Institute of Technology, Kharagpur, India
Sujit Kumar Bhutia
Department of Biotechnology, Indian Institute of Technology, Kharagpur, India
Tapas K Maiti
Department of Biotechnology, Indian Institute of Technology Kharagpur, India

ABSTRACT

The present study investigates macrophage-stimulating polysaccharides isolated from the Barometer Earthstar gastroid mushroom, Astraeus hygrometricus. The alkaline-extracted and ion exchange−purified polysaccharide was designated AE2. This polysaccharide is composed of 69% glucose, with a high molecular weight. It was studied with respect to macrophage-stimulating activity in vitro and exhibited enhanced production of nitric oxide and cytokines. The phagocytosis by AE2-treated macrophages was more than twofold that of the controls. In addition, there was a higher surface localization of lipid rafts upon treatment. The mode of action of AE2 on macrophages may be attributed to its binding to the cell surface, followed by its internalization.


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