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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i3.40
pages 249-257

Ergosterol Peroxide and 9,11-Dehydroergosterol Peroxide from Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelia Inhibit the Growth of Human Breast Adenocarcinoma MCF-7 Cells

Lin Zheng
Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
Jianyong Si
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Yum-Shing Wong
The Chinese University of Hong Kong


Two fungal steroids, namely, ergosterol peroxide (EP) and (9,11-dehydroergosterol peroxide (9(11)-DHEP), were isolated and identified from the mycelia of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum, grown under submerged culture. Both EP and 9(11)-DHEP exhibited inhibitory effects on human breast adenocarcinoma MCF-7 cells. The nontumorigenic human breast MCF-10-2A cells were less susceptible to these two compounds. Flow cytometric analyses suggested that these two fungal steroids inhibited the growth of MCF-7 cells by inducing cell apoptosis.