Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i3.40
pages 249-257

Ergosterol Peroxide and 9,11-Dehydroergosterol Peroxide from Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelia Inhibit the Growth of Human Breast Adenocarcinoma MCF-7 Cells

Lin Zheng
Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
Jianyong Si
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Yum-Shing Wong
The Chinese University of Hong Kong


Two fungal steroids, namely, ergosterol peroxide (EP) and (9,11-dehydroergosterol peroxide (9(11)-DHEP), were isolated and identified from the mycelia of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum, grown under submerged culture. Both EP and 9(11)-DHEP exhibited inhibitory effects on human breast adenocarcinoma MCF-7 cells. The nontumorigenic human breast MCF-10-2A cells were less susceptible to these two compounds. Flow cytometric analyses suggested that these two fungal steroids inhibited the growth of MCF-7 cells by inducing cell apoptosis.

Articles with similar content:

Cytotoxic Activities of Ergosta-4, 6, 8 (14), 22-tetraen-3-one from the Sclerotia of Grifola umbellata (Pers.) Pilát
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Kang Hyeon Ka, Youngki Park, Jin Kwon Ahn, Wi Young Lee, Hak Ju Lee
Mycochemical Investigation of the Turkey Tail Medicinal Mushroom Trametes versicolor (Higher Basidiomycetes): A Potential Application of the Isolated Compounds in Documented Pharmacological Studies
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 3
Yaghoub Amanzadeh, Seyed Esmaeel Sadat-Ebrahimi, Saeed Ali Mousazadeh, Emran Habibi
Submerged Cultured Mycelium Extracts of Higher Basidiomycetes Mushrooms Selectively Inhibit Proliferation and Induce Differentiation of K562 Human Chronic Myelogenous Leukemia Cells
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 3
Majed Yassin, Jamal A. Mahajna
Protective Effect of Antioxidant Extracts from Grey Oyster Mushroom, Pleurotus pulmonarius (Agaricomycetes), Against Human Low-Density Lipoprotein Oxidation and Aortic Endothelial Cell Damage
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 2
Noorlidah Abdullah, Nurhayati Zainal Abidin, Mohamad Hamdi Zainal Abidin
Antiproliferative Effects of Sclerotial Polysaccharides from Polyporus rhinocerus Cooke (Aphyllophoromycetideae) on Different Kinds of Leukemic Cells
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 3
Ka-Hing Wong, Peter Chi Keung Cheung, Connie K. M. Lai