Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i3.40
pages 249-257

Ergosterol Peroxide and 9,11-Dehydroergosterol Peroxide from Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelia Inhibit the Growth of Human Breast Adenocarcinoma MCF-7 Cells

Lin Zheng
Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
Jianyong Si
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Yum-Shing Wong
The Chinese University of Hong Kong

ABSTRACT

Two fungal steroids, namely, ergosterol peroxide (EP) and (9,11-dehydroergosterol peroxide (9(11)-DHEP), were isolated and identified from the mycelia of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum, grown under submerged culture. Both EP and 9(11)-DHEP exhibited inhibitory effects on human breast adenocarcinoma MCF-7 cells. The nontumorigenic human breast MCF-10-2A cells were less susceptible to these two compounds. Flow cytometric analyses suggested that these two fungal steroids inhibited the growth of MCF-7 cells by inducing cell apoptosis.


Articles with similar content:

Cytotoxic Activities of Ergosta-4, 6, 8 (14), 22-tetraen-3-one from the Sclerotia of Grifola umbellata (Pers.) Pilát
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Kang Hyeon Ka, Youngki Park, Jin Kwon Ahn, Wi Young Lee, Hak Ju Lee
Investigation of Antiproliferative Effect of Ether and Ethanol Extracts of Birch Polypore Medicinal Mushroom, Piptoporus betulinus (Bull.:Fr.) P. Karst. (Higher Basidiomycetes) In Vitro Grown Mycelium
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 6
Lucyna Kapka-Skrzypczak, Wojciech Rzeski, Jozef Kaczor, Katarzyna Walczak, Martyna Kandefer-Szerszen, Malgorzata Cyranka, Marcin Graz
Antioxidant and Cytotoxic Activities of Ethanolic Extracts and Isolated Fractions of Species of the Genus Phellinus Quél. (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 2
Yanfang Liu, Yan Yang, Libin Ye, Jing-Song Zhang, Jinxia Hu, Na Feng, Hui Chen, Qing-jiu Tang Tang
Selective Cytotoxic Activity of Se-Methyl-Seleno-L-Cysteine– and Se-Polysaccharide–Containing Extracts from Shiitake Medicinal Mushroom, Lentinus edodes (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 8
Maciej Dawidowski, Iwonna Rahden-Staroń, Marzenna Klimaszewska, Jadwiga Turło, Agnieszka Szczepanska, Dagmara Kurpios-Piec, Emilia Orzechowska, Piotr Podsadni, Emilia Grosicka-Maciag, Sandra Górska
Cytotoxic Activities of Funalia trogii (Berk.) Bond. Et. Singer ATCC 200800 Bioactive Extract on HeLa Cells and Fibroblast Cells
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Mehmet A. Mazmanci, Ali Unyayar, Murat Demirbilek, Ozlem Cekic, Melisa Turkoglu, Hatice Atacag, Serpil Unyayar, Emrah A. Erkurt, Ayla Celik