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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i2.10
pages 111-121

Immunomodulatory Effect of the Polysaccharide-Rich Fraction from Sclerotium of Medicinal Mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb/c Mice

Chia-Yu Ma
Department of Food and Beverage Management, Technology and Science Institute of Northern Taiwan, Taipei City 112, Taiwan
Wan-Ching Chang
Graduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan
Hung-Min Chang
Graduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan
James Swi-Bea Wu
Graduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan

ABSTRACT

Dried sclerotia of medicinal mushroom Poria cocos F.A.Wolf were extracted with cold water. The extract was precipitated by ethanol and then lyophilized to obtain the polysaccharide-rich fraction (PRF). The immunomodulatory effect of the PRF on Balb/c mice was investigated. Oral administration of the PRF did not affect the growth of healthy mice. The relative proliferation ratio of phytohemagglutinin-stimulated splenocytes increased significantly, whereas the natural killer cell activity and numbers of T, T helper, T cytotoxic (Tc), and B cells remained unchanged, excluding the occurrence of a nonspecific immune-response. Some other healthy mice were immunized with ovalbumin (OVA) to conduct specific immune-response experiments. Oral administration of PRF at 200 mg/kg bw to the immunized mice increased the Tc percentage among splenocytes but reduced anti-OVA immunoglobulin G and M levels significantly, indicating that PRF could modulate the specific immune response of Balb/c mice and that the modulation is via the activation of T cells.


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